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Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected].
J Nat Prod. 2010 Feb 26; 73(2):93-8.JN

Abstract

Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Nian Y
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Zhang YL
No affiliation info available
Chen JC
No affiliation info available
Lu L
No affiliation info available
Qiu MH
No affiliation info available
Qing C
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCimicifugaDrug Screening Assays, AntitumorDrugs, Chinese HerbalGlycosidesHT29 CellsHep G2 CellsHumansMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant RootsStereoisomerismTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20121210

Citation

Nian, Yin, et al. "Cytotoxic Chemical Constituents From the Roots of Cimicifuga Foetida. [corrected]." Journal of Natural Products, vol. 73, no. 2, 2010, pp. 93-8.
Nian Y, Zhang YL, Chen JC, et al. Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected]. J Nat Prod. 2010;73(2):93-8.
Nian, Y., Zhang, Y. L., Chen, J. C., Lu, L., Qiu, M. H., & Qing, C. (2010). Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected]. Journal of Natural Products, 73(2), 93-8. https://doi.org/10.1021/np9003855
Nian Y, et al. Cytotoxic Chemical Constituents From the Roots of Cimicifuga Foetida. [corrected]. J Nat Prod. 2010 Feb 26;73(2):93-8. PubMed PMID: 20121210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected]. AU - Nian,Yin, AU - Zhang,Yan-Li, AU - Chen,Jian-Chao, AU - Lu,Lu, AU - Qiu,Ming-Hua, AU - Qing,Chen, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/4/1/medline SP - 93 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 2 N2 - Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20121210/Cytotoxic_chemical_constituents_from_the_roots_of_Cimicifuga_foetida__[corrected]_ L2 - https://doi.org/10.1021/np9003855 DB - PRIME DP - Unbound Medicine ER -