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Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial.

Abstract

OBJECTIVES

To determine whether cardiovascular exercise training resulted in improved antibody responses to influenza vaccination in sedentary elderly people who exhibited poor vaccine responses.

DESIGN

Single-site randomized parallel-arm 10-month controlled trial.

SETTING

University of Illinois at Urbana-Champaign.

PARTICIPANTS

One hundred forty-four sedentary, healthy older (69.9 +/- 0.4) adults.

INTERVENTIONS

Moderate (60-70% maximal oxygen uptake) cardiovascular exercise was compared with flexibility and balance training.

MEASUREMENTS

The primary outcome was influenza vaccine response, as measured according to hemagglutination inhibition (HI) anti-influenza antibody titer and seroprotective responses (HI titer > or =40). Secondary measures included cardiovascular fitness and body composition.

RESULTS

Of the 160 participants enrolled, 144 (90%) completed the 10-month intervention with excellent compliance ( approximately 83%). Cardiovascular, but not flexibility, exercise intervention resulted in improvements in indices of cardiovascular fitness, including maximal oxygen uptake. Although not affecting peak (e.g., 3 and 6 weeks) postvaccine anti-influenza HI titers, cardiovascular exercise resulted in a significant increase in seroprotection 24 weeks after vaccination (30-100% dependent on vaccine variant), whereas flexibility training did not.

CONCLUSION

Participants randomized to cardiovascular exercise experienced improvements in influenza seroprotection throughout the entire influenza season, whereas those in the balance and flexibility intervention did not. Although there were no differences in reported respiratory tract infections, the exercise group exhibited reduced overall illness severity and sleep disturbance. These data support the hypothesis that regular endurance exercise improves influenza vaccine responses.

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  • Authors+Show Affiliations

    ,

    Department of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL 61801, USA. woods1@illinois.edu

    , , , , , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Antibodies, Viral
    Cardiovascular System
    Double-Blind Method
    Exercise
    Female
    Humans
    Influenza Vaccines
    Male
    Middle Aged
    Prospective Studies
    Sedentary Behavior

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20121985

    Citation

    Woods, Jeffrey A., et al. "Cardiovascular Exercise Training Extends Influenza Vaccine Seroprotection in Sedentary Older Adults: the Immune Function Intervention Trial." Journal of the American Geriatrics Society, vol. 57, no. 12, 2009, pp. 2183-91.
    Woods JA, Keylock KT, Lowder T, et al. Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial. J Am Geriatr Soc. 2009;57(12):2183-91.
    Woods, J. A., Keylock, K. T., Lowder, T., Vieira, V. J., Zelkovich, W., Dumich, S., ... McAuley, E. (2009). Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial. Journal of the American Geriatrics Society, 57(12), pp. 2183-91. doi:10.1111/j.1532-5415.2009.02563.x.
    Woods JA, et al. Cardiovascular Exercise Training Extends Influenza Vaccine Seroprotection in Sedentary Older Adults: the Immune Function Intervention Trial. J Am Geriatr Soc. 2009;57(12):2183-91. PubMed PMID: 20121985.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial. AU - Woods,Jeffrey A, AU - Keylock,K Todd, AU - Lowder,Thomas, AU - Vieira,Victoria J, AU - Zelkovich,William, AU - Dumich,Sara, AU - Colantuano,Kim, AU - Lyons,Kristin, AU - Leifheit,Kurt, AU - Cook,Marc, AU - Chapman-Novakofski,Karen, AU - McAuley,Edward, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/3/4/medline SP - 2183 EP - 91 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 57 IS - 12 N2 - OBJECTIVES: To determine whether cardiovascular exercise training resulted in improved antibody responses to influenza vaccination in sedentary elderly people who exhibited poor vaccine responses. DESIGN: Single-site randomized parallel-arm 10-month controlled trial. SETTING: University of Illinois at Urbana-Champaign. PARTICIPANTS: One hundred forty-four sedentary, healthy older (69.9 +/- 0.4) adults. INTERVENTIONS: Moderate (60-70% maximal oxygen uptake) cardiovascular exercise was compared with flexibility and balance training. MEASUREMENTS: The primary outcome was influenza vaccine response, as measured according to hemagglutination inhibition (HI) anti-influenza antibody titer and seroprotective responses (HI titer > or =40). Secondary measures included cardiovascular fitness and body composition. RESULTS: Of the 160 participants enrolled, 144 (90%) completed the 10-month intervention with excellent compliance ( approximately 83%). Cardiovascular, but not flexibility, exercise intervention resulted in improvements in indices of cardiovascular fitness, including maximal oxygen uptake. Although not affecting peak (e.g., 3 and 6 weeks) postvaccine anti-influenza HI titers, cardiovascular exercise resulted in a significant increase in seroprotection 24 weeks after vaccination (30-100% dependent on vaccine variant), whereas flexibility training did not. CONCLUSION: Participants randomized to cardiovascular exercise experienced improvements in influenza seroprotection throughout the entire influenza season, whereas those in the balance and flexibility intervention did not. Although there were no differences in reported respiratory tract infections, the exercise group exhibited reduced overall illness severity and sleep disturbance. These data support the hypothesis that regular endurance exercise improves influenza vaccine responses. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/20121985/Cardiovascular_exercise_training_extends_influenza_vaccine_seroprotection_in_sedentary_older_adults:_the_immune_function_intervention_trial_ L2 - https://doi.org/10.1111/j.1532-5415.2009.02563.x DB - PRIME DP - Unbound Medicine ER -