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Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte.
Brain Res. 2010 Apr 06; 1323:149-51.BR

Abstract

Cerebral ischemia-reperfusion injury (IRI) is a complex process resulting in cellular damage and death. Many studies have reported that an ischemic preconditioning could induce protection against ischemic insult. However, the safety concerns and practical feasibility have limited the application of ischemia preconditioning in practice. Subsequently, a number of substances including endotoxin and cytokines etc. have proven effective in inducing ischemic tolerance in the neurocyte. Unfortunately, the application of these substances to the clinical practice of neurosurgery still remains questionable for their toxicity or side effects. Therefore, a novel therapy to protect against cerebral IRI requires further study. Several recent studies confirmed that repeated hyperbaric oxygen preconditioning (HBO-PC) prior to cerebral ischemia or spinal cord ischemia can provide neuroprotection. HBO as a therapeutic measure has been widely accepted for its convenience and safety. However, information about the mechanism of how this neuroprotection works is still very limited. We hypothesize that autophagy induction is involved in HBO-PC induced neuroprotection on IRI in neurocyte. The hypothesis reveals that autophagy may be a new therapeutic target for cerebral IRI.

Authors+Show Affiliations

Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an 710032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20123088

Citation

Wang, Yong-Chun, et al. "Hyperbaric Oxygen Preconditioning Reduces Ischemia-reperfusion Injury By Stimulating Autophagy in Neurocyte." Brain Research, vol. 1323, 2010, pp. 149-51.
Wang YC, Zhang S, Du TY, et al. Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte. Brain Res. 2010;1323:149-51.
Wang, Y. C., Zhang, S., Du, T. Y., Wang, B., & Sun, X. Q. (2010). Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte. Brain Research, 1323, 149-51. https://doi.org/10.1016/j.brainres.2010.01.074
Wang YC, et al. Hyperbaric Oxygen Preconditioning Reduces Ischemia-reperfusion Injury By Stimulating Autophagy in Neurocyte. Brain Res. 2010 Apr 6;1323:149-51. PubMed PMID: 20123088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte. AU - Wang,Yong-Chun, AU - Zhang,Shu, AU - Du,Ting-Yuan, AU - Wang,Bing, AU - Sun,Xi-Qing, Y1 - 2010/02/01/ PY - 2009/12/02/received PY - 2010/01/24/revised PY - 2010/01/27/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/12/14/medline SP - 149 EP - 51 JF - Brain research JO - Brain Res. VL - 1323 N2 - Cerebral ischemia-reperfusion injury (IRI) is a complex process resulting in cellular damage and death. Many studies have reported that an ischemic preconditioning could induce protection against ischemic insult. However, the safety concerns and practical feasibility have limited the application of ischemia preconditioning in practice. Subsequently, a number of substances including endotoxin and cytokines etc. have proven effective in inducing ischemic tolerance in the neurocyte. Unfortunately, the application of these substances to the clinical practice of neurosurgery still remains questionable for their toxicity or side effects. Therefore, a novel therapy to protect against cerebral IRI requires further study. Several recent studies confirmed that repeated hyperbaric oxygen preconditioning (HBO-PC) prior to cerebral ischemia or spinal cord ischemia can provide neuroprotection. HBO as a therapeutic measure has been widely accepted for its convenience and safety. However, information about the mechanism of how this neuroprotection works is still very limited. We hypothesize that autophagy induction is involved in HBO-PC induced neuroprotection on IRI in neurocyte. The hypothesis reveals that autophagy may be a new therapeutic target for cerebral IRI. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/20123088/Hyperbaric_oxygen_preconditioning_reduces_ischemia_reperfusion_injury_by_stimulating_autophagy_in_neurocyte_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(10)00228-3 DB - PRIME DP - Unbound Medicine ER -