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Past medical history and pancreatic cancer risk: Results from a multicenter case-control study.
Ann Epidemiol 2010; 20(2):92-8AE

Abstract

PURPOSE

To investigate risk factors that may be linked to pancreatic cancer.

METHODS

We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland.

RESULTS

After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82).

CONCLUSIONS

Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.

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    Authors+Show Affiliations

    Maisonneuve P
    European Institute of Oncology, Milan, Italy.
    Lowenfels AB
    No affiliation info available
    Bueno-de-Mesquita HB
    No affiliation info available
    Ghadirian P
    No affiliation info available
    Baghurst PA
    No affiliation info available
    Zatonski WA
    No affiliation info available
    Miller AB
    No affiliation info available
    Duell EJ
    No affiliation info available
    Boffetta P
    No affiliation info available
    Boyle P
    No affiliation info available

    MeSH

    AdultAgedAged, 80 and overAustraliaCanadaCase-Control StudiesDiabetes MellitusFemaleHumansMaleMiddle AgedNetherlandsPancreatic NeoplasmsPancreatitisPolandRisk FactorsSmoking

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20123159

    Citation

    Maisonneuve, Patrick, et al. "Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-control Study." Annals of Epidemiology, vol. 20, no. 2, 2010, pp. 92-8.
    Maisonneuve P, Lowenfels AB, Bueno-de-Mesquita HB, et al. Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. Ann Epidemiol. 2010;20(2):92-8.
    Maisonneuve, P., Lowenfels, A. B., Bueno-de-Mesquita, H. B., Ghadirian, P., Baghurst, P. A., Zatonski, W. A., ... Boyle, P. (2010). Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. Annals of Epidemiology, 20(2), pp. 92-8. doi:10.1016/j.annepidem.2009.11.010.
    Maisonneuve P, et al. Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-control Study. Ann Epidemiol. 2010;20(2):92-8. PubMed PMID: 20123159.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. AU - Maisonneuve,Patrick, AU - Lowenfels,Albert B, AU - Bueno-de-Mesquita,H Bas, AU - Ghadirian,Parviz, AU - Baghurst,Peter A, AU - Zatonski,Witold A, AU - Miller,Anthony B, AU - Duell,Eric J, AU - Boffetta,Paolo, AU - Boyle,Peter, PY - 2009/07/24/received PY - 2009/11/16/revised PY - 2009/11/25/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/5/6/medline SP - 92 EP - 8 JF - Annals of epidemiology JO - Ann Epidemiol VL - 20 IS - 2 N2 - PURPOSE: To investigate risk factors that may be linked to pancreatic cancer. METHODS: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. RESULTS: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). CONCLUSIONS: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/20123159/Past_medical_history_and_pancreatic_cancer_risk:_Results_from_a_multicenter_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(09)00366-4 DB - PRIME DP - Unbound Medicine ER -