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Past medical history and pancreatic cancer risk: Results from a multicenter case-control study.
Ann Epidemiol 2010; 20(2):92-8AE

Abstract

PURPOSE

To investigate risk factors that may be linked to pancreatic cancer.

METHODS

We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland.

RESULTS

After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82).

CONCLUSIONS

Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.

Authors+Show Affiliations

European Institute of Oncology, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20123159

Citation

Maisonneuve, Patrick, et al. "Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-control Study." Annals of Epidemiology, vol. 20, no. 2, 2010, pp. 92-8.
Maisonneuve P, Lowenfels AB, Bueno-de-Mesquita HB, et al. Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. Ann Epidemiol. 2010;20(2):92-8.
Maisonneuve, P., Lowenfels, A. B., Bueno-de-Mesquita, H. B., Ghadirian, P., Baghurst, P. A., Zatonski, W. A., ... Boyle, P. (2010). Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. Annals of Epidemiology, 20(2), pp. 92-8. doi:10.1016/j.annepidem.2009.11.010.
Maisonneuve P, et al. Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-control Study. Ann Epidemiol. 2010;20(2):92-8. PubMed PMID: 20123159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Past medical history and pancreatic cancer risk: Results from a multicenter case-control study. AU - Maisonneuve,Patrick, AU - Lowenfels,Albert B, AU - Bueno-de-Mesquita,H Bas, AU - Ghadirian,Parviz, AU - Baghurst,Peter A, AU - Zatonski,Witold A, AU - Miller,Anthony B, AU - Duell,Eric J, AU - Boffetta,Paolo, AU - Boyle,Peter, PY - 2009/07/24/received PY - 2009/11/16/revised PY - 2009/11/25/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/5/6/medline SP - 92 EP - 8 JF - Annals of epidemiology JO - Ann Epidemiol VL - 20 IS - 2 N2 - PURPOSE: To investigate risk factors that may be linked to pancreatic cancer. METHODS: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. RESULTS: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). CONCLUSIONS: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/20123159/Past_medical_history_and_pancreatic_cancer_risk:_Results_from_a_multicenter_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(09)00366-4 DB - PRIME DP - Unbound Medicine ER -