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Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA).
J Stroke Cerebrovasc Dis. 2010 Jan; 19(1):58-65.JS

Abstract

INTRODUCTION

Carotid intima-media thickness (IMT) is a subclinical marker of atherosclerosis and a strong predictor of stroke. Pericardial fat (PF), the fat depot around the heart, has been associated with several atherosclerosis risk factors. We sought to examine the association between carotid IMT and PF, and to examine whether such an association is independent from common atherosclerosis risk factors including measures of overall adiposity.

METHODS

Unadjusted and multivariable-adjusted linear regression analysis was used to examine associations between common carotid artery (CCA) IMT and internal carotid artery (ICA) IMT with PF in a random sample of 996 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent carotid ultrasound and chest computed tomography at baseline examination.

RESULTS

A significant positive correlation was observed between PF and CCA-IMT (r=0.27, P < .0001) and ICA-IMT (r=0.17, P < .0001). In an unadjusted sex-specific linear regression analysis, there was a significant association between PF (1-SD difference) and CCA-IMT (mm) in both women (beta coefficient [95% confidence interval]: 0.06 [0.04, 0.08], P < .0001) and men (0.03 [0.01, 0.05], P < .0002), an association that persisted after further adjusting for age and ethnicity (0.02 [+0.00, 0.04], P=.0120 for women, and 0.02 [+0.00, 0.03], P=.0208 for men). However, after additional adjustment for atherosclerosis risk factors and either body mass index or waist circumference, these relations were no longer significant in either sex. In similar analyses, PF was significantly associated with ICA-IMT in both men (0.11 [0.06, 0.15], P < .0001) and women (0.08 [0.02, 0.13], P=.0041). These relations were no longer significant in women in multivariable-adjusted models, but persisted in men in all models except after adjusting for age, ethnicity, and waist circumference.

CONCLUSIONS

In the general population PF is associated with carotid IMT, an association that possibly is not independent from markers of overall adiposity or common atherosclerosis risk factors.

Authors+Show Affiliations

Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA. esoliman@wfubmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

20123228

Citation

Soliman, Elsayed Z., et al. "Association Between Carotid Intima-media Thickness and Pericardial Fat in the Multi-Ethnic Study of Atherosclerosis (MESA)." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 19, no. 1, 2010, pp. 58-65.
Soliman EZ, Ding J, Hsu FC, et al. Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA). J Stroke Cerebrovasc Dis. 2010;19(1):58-65.
Soliman, E. Z., Ding, J., Hsu, F. C., Carr, J. J., Polak, J. F., & Goff, D. C. (2010). Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA). Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 19(1), 58-65. https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.03.008
Soliman EZ, et al. Association Between Carotid Intima-media Thickness and Pericardial Fat in the Multi-Ethnic Study of Atherosclerosis (MESA). J Stroke Cerebrovasc Dis. 2010;19(1):58-65. PubMed PMID: 20123228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA). AU - Soliman,Elsayed Z, AU - Ding,Jingzhong, AU - Hsu,Fang-Chi, AU - Carr,J Jeffrey, AU - Polak,Joseph F, AU - Goff,David C,Jr PY - 2009/01/28/received PY - 2009/03/09/revised PY - 2009/03/26/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/4/16/medline SP - 58 EP - 65 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 19 IS - 1 N2 - INTRODUCTION: Carotid intima-media thickness (IMT) is a subclinical marker of atherosclerosis and a strong predictor of stroke. Pericardial fat (PF), the fat depot around the heart, has been associated with several atherosclerosis risk factors. We sought to examine the association between carotid IMT and PF, and to examine whether such an association is independent from common atherosclerosis risk factors including measures of overall adiposity. METHODS: Unadjusted and multivariable-adjusted linear regression analysis was used to examine associations between common carotid artery (CCA) IMT and internal carotid artery (ICA) IMT with PF in a random sample of 996 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent carotid ultrasound and chest computed tomography at baseline examination. RESULTS: A significant positive correlation was observed between PF and CCA-IMT (r=0.27, P < .0001) and ICA-IMT (r=0.17, P < .0001). In an unadjusted sex-specific linear regression analysis, there was a significant association between PF (1-SD difference) and CCA-IMT (mm) in both women (beta coefficient [95% confidence interval]: 0.06 [0.04, 0.08], P < .0001) and men (0.03 [0.01, 0.05], P < .0002), an association that persisted after further adjusting for age and ethnicity (0.02 [+0.00, 0.04], P=.0120 for women, and 0.02 [+0.00, 0.03], P=.0208 for men). However, after additional adjustment for atherosclerosis risk factors and either body mass index or waist circumference, these relations were no longer significant in either sex. In similar analyses, PF was significantly associated with ICA-IMT in both men (0.11 [0.06, 0.15], P < .0001) and women (0.08 [0.02, 0.13], P=.0041). These relations were no longer significant in women in multivariable-adjusted models, but persisted in men in all models except after adjusting for age, ethnicity, and waist circumference. CONCLUSIONS: In the general population PF is associated with carotid IMT, an association that possibly is not independent from markers of overall adiposity or common atherosclerosis risk factors. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/20123228/Association_between_carotid_intima_media_thickness_and_pericardial_fat_in_the_Multi_Ethnic_Study_of_Atherosclerosis__MESA__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(09)00066-4 DB - PRIME DP - Unbound Medicine ER -