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Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke.
J Stroke Cerebrovasc Dis 2010; 19(1):66-72JS

Abstract

BACKGROUND

Mean platelet volume (MPV) is an indicator of platelet function or reactivity. Platelets play an important role in the pathophysiology of ischemic stroke but the effect of platelet count (PC) and dysfunction in the pathogenesis of hemorrhagic stroke is poorly understood. We have investigated the possibility of MPV and PC being an independent risk factor of ischemic and haemorrhagic stroke and their effect on prognosis.

METHODS

We prospectively studied 692 patients with either ischemic or hemorrhagic stroke and compared them with 208 control subjects with similar risk factors, but without evidence of vascular events. The association of MPV and PC with cause, localization, and size of the infarct or hemorrhage was examined. Prognosis was determined by Glasgow Outcome Scale. By multivariate logistic regression analysis, the influence of MPV and PC on stroke subtype and prognosis was determined.

RESULTS

MPV and PC were observed as independent risk factors for ischemic stroke (P = .007, odds ratio [OR] = 0.866; P = .000, OR = 0.996; 95% confidence interval [CI], respectively). There was a negative and significant correlation between PC and hemorrhagic stroke (P = .001), but no association was found with MPV (P > .05). MPV and PC were not statistically significant related to etiological subgroups, localization, and size of the infarct or hemorrhage (P > .05). Ischemic group MPV (P = .013, OR = 1.02, 95% CI) and hemorrhagic group PC were in correlation with worse outcome (P = .001, OR = 1.004, 95% CI).

CONCLUSION

MPV, may be an early and important predictor for the prognosis of ischemic stroke, whereas for hemorrhagic stroke PC has a role for outcome.

Authors+Show Affiliations

Department of First Neurology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey. fusundomac@yahoo.com.tr

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20123229

Citation

Mayda-Domaç, Füsun, et al. "Prognostic Role of Mean Platelet Volume and Platelet Count in Ischemic and Hemorrhagic Stroke." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 19, no. 1, 2010, pp. 66-72.
Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010;19(1):66-72.
Mayda-Domaç, F., Misirli, H., & Yilmaz, M. (2010). Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 19(1), pp. 66-72. doi:10.1016/j.jstrokecerebrovasdis.2009.03.003.
Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic Role of Mean Platelet Volume and Platelet Count in Ischemic and Hemorrhagic Stroke. J Stroke Cerebrovasc Dis. 2010;19(1):66-72. PubMed PMID: 20123229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. AU - Mayda-Domaç,Füsun, AU - Misirli,Handan, AU - Yilmaz,Mustafa, PY - 2009/02/13/received PY - 2009/03/06/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/4/16/medline SP - 66 EP - 72 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 19 IS - 1 N2 - BACKGROUND: Mean platelet volume (MPV) is an indicator of platelet function or reactivity. Platelets play an important role in the pathophysiology of ischemic stroke but the effect of platelet count (PC) and dysfunction in the pathogenesis of hemorrhagic stroke is poorly understood. We have investigated the possibility of MPV and PC being an independent risk factor of ischemic and haemorrhagic stroke and their effect on prognosis. METHODS: We prospectively studied 692 patients with either ischemic or hemorrhagic stroke and compared them with 208 control subjects with similar risk factors, but without evidence of vascular events. The association of MPV and PC with cause, localization, and size of the infarct or hemorrhage was examined. Prognosis was determined by Glasgow Outcome Scale. By multivariate logistic regression analysis, the influence of MPV and PC on stroke subtype and prognosis was determined. RESULTS: MPV and PC were observed as independent risk factors for ischemic stroke (P = .007, odds ratio [OR] = 0.866; P = .000, OR = 0.996; 95% confidence interval [CI], respectively). There was a negative and significant correlation between PC and hemorrhagic stroke (P = .001), but no association was found with MPV (P > .05). MPV and PC were not statistically significant related to etiological subgroups, localization, and size of the infarct or hemorrhage (P > .05). Ischemic group MPV (P = .013, OR = 1.02, 95% CI) and hemorrhagic group PC were in correlation with worse outcome (P = .001, OR = 1.004, 95% CI). CONCLUSION: MPV, may be an early and important predictor for the prognosis of ischemic stroke, whereas for hemorrhagic stroke PC has a role for outcome. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/20123229/Prognostic_role_of_mean_platelet_volume_and_platelet_count_in_ischemic_and_hemorrhagic_stroke_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(09)00047-0 DB - PRIME DP - Unbound Medicine ER -