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Dopamine receptors and L-dopa-induced dyskinesia.
Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 4:S8-12.PR

Abstract

In the majority of Parkinson's disease patients, chronic dopamine replacement therapy leads to involuntary aimless movements known as l-dopa-induced dyskinesia. While mechanisms involved in dyskinesia occurrence are still unclear, dopamine receptors undoubtedly have a central role in their pathophysiology. Here we review current knowledge and evidence for their involvement in dyskinesia genesis and manifestation. We propose that an anti-dyskinetic strategy should target the D1/D3 signalling cascade, as targeting D2 receptor signalling seems to inherently convey anti-therapeutic effects deleterious to patients. As more molecular tools are made available, we will better understand the role of each receptor and its associated signalling cascade in Parkinson's disease and L-dopa-induced dyskinesia, hopefully in a way amenable to patients.

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Authors+Show Affiliations

Berthet A
Université Victor-Segalen Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France.
Bezard E
No affiliation info available

MeSH

AnimalsDopamine AgonistsDyskinesia, Drug-InducedHumansLevodopaParkinson DiseaseReceptors, DopamineSignal Transduction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20123563

Clinical Trial Links

Sleep Homeostasis in Parkinson's Disease

Citation

Berthet, Amandine, and Erwan Bezard. "Dopamine Receptors and L-dopa-induced Dyskinesia." Parkinsonism & Related Disorders, vol. 15 Suppl 4, 2009, pp. S8-12.
Berthet A, Bezard E. Dopamine receptors and L-dopa-induced dyskinesia. Parkinsonism Relat Disord. 2009;15 Suppl 4:S8-12.
Berthet, A., & Bezard, E. (2009). Dopamine receptors and L-dopa-induced dyskinesia. Parkinsonism & Related Disorders, 15 Suppl 4, S8-12. https://doi.org/10.1016/S1353-8020(09)70827-2
Berthet A, Bezard E. Dopamine Receptors and L-dopa-induced Dyskinesia. Parkinsonism Relat Disord. 2009;15 Suppl 4:S8-12. PubMed PMID: 20123563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine receptors and L-dopa-induced dyskinesia. AU - Berthet,Amandine, AU - Bezard,Erwan, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/10/1/medline SP - S8 EP - 12 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 Suppl 4 N2 - In the majority of Parkinson's disease patients, chronic dopamine replacement therapy leads to involuntary aimless movements known as l-dopa-induced dyskinesia. While mechanisms involved in dyskinesia occurrence are still unclear, dopamine receptors undoubtedly have a central role in their pathophysiology. Here we review current knowledge and evidence for their involvement in dyskinesia genesis and manifestation. We propose that an anti-dyskinetic strategy should target the D1/D3 signalling cascade, as targeting D2 receptor signalling seems to inherently convey anti-therapeutic effects deleterious to patients. As more molecular tools are made available, we will better understand the role of each receptor and its associated signalling cascade in Parkinson's disease and L-dopa-induced dyskinesia, hopefully in a way amenable to patients. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/20123563/Dopamine_receptors_and_L_dopa_induced_dyskinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(09)70827-2 DB - PRIME DP - Unbound Medicine ER -