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Probiotics for maintaining remission of ulcerative colitis in adults.
Ann Pharmacother. 2010 Mar; 44(3):565-71.AP

Abstract

OBJECTIVE

To evaluate evidence for probiotic efficacy for maintaining remission of ulcerative colitis (UC) in adults.

DATA SOURCES

A MEDLINE search (1948-November 2009) was conducted using ulcerative colitis and probiotics as terms for identifying pertinent studies. Search limits included English language and humans. Additional information was obtained from bibliographies.

STUDY SELECTION AND DATA EXTRACTION

Prospective trials published in English and conducted in adults were included. Two open-label and 3 double-blind randomized trials evaluated probiotic efficacy for maintaining remission of UC. Clinical and surrogate markers for maintaining remission of UC were assessed.

DATA SYNTHESIS

A relationship between immune response and gastrointestinal microbials appears to be involved in the mechanism of UC. Trial results comparing the probiotic Escherichia coli Nissle 1917 to mesalazine have reported equivalent rates of UC relapse. Treatment with Lactobacillus rhamnosus GG strain alone or in combination with mesalazine resulted in a nonsignificant odds ratio decrease for relapse and a significant increase in time to relapse compared to treatment with mesalazine alone. Additionally, bifidobacteria-fermented milk-supplemented patients had significant reductions in UC exacerbations when compared to nonsupplemented patients. Probiotics were well tolerated, with adverse event rates similar between treatments.

CONCLUSIONS

Studies evaluating probiotics for maintaining remission of UC are limited by trial design and use of different probiotics with variable bacterial contents. Thus, questions remain regarding optimal probiotic, dosing, specific patient populations, and placement in therapy. To answer these questions, large, randomized, controlled trials need to be conducted before probiotics can be routinely recommended for maintaining remission of UC.

Authors+Show Affiliations

Virginia Commonwealth University Health System/Medical College of Virginia Hospitals, Richmond, VA 23298, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20124461

Citation

Do, Vi T., et al. "Probiotics for Maintaining Remission of Ulcerative Colitis in Adults." The Annals of Pharmacotherapy, vol. 44, no. 3, 2010, pp. 565-71.
Do VT, Baird BG, Kockler DR. Probiotics for maintaining remission of ulcerative colitis in adults. Ann Pharmacother. 2010;44(3):565-71.
Do, V. T., Baird, B. G., & Kockler, D. R. (2010). Probiotics for maintaining remission of ulcerative colitis in adults. The Annals of Pharmacotherapy, 44(3), 565-71. https://doi.org/10.1345/aph.1M498
Do VT, Baird BG, Kockler DR. Probiotics for Maintaining Remission of Ulcerative Colitis in Adults. Ann Pharmacother. 2010;44(3):565-71. PubMed PMID: 20124461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics for maintaining remission of ulcerative colitis in adults. AU - Do,Vi T, AU - Baird,Brian G, AU - Kockler,Denise R, Y1 - 2010/02/02/ PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/5/19/medline SP - 565 EP - 71 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 44 IS - 3 N2 - OBJECTIVE: To evaluate evidence for probiotic efficacy for maintaining remission of ulcerative colitis (UC) in adults. DATA SOURCES: A MEDLINE search (1948-November 2009) was conducted using ulcerative colitis and probiotics as terms for identifying pertinent studies. Search limits included English language and humans. Additional information was obtained from bibliographies. STUDY SELECTION AND DATA EXTRACTION: Prospective trials published in English and conducted in adults were included. Two open-label and 3 double-blind randomized trials evaluated probiotic efficacy for maintaining remission of UC. Clinical and surrogate markers for maintaining remission of UC were assessed. DATA SYNTHESIS: A relationship between immune response and gastrointestinal microbials appears to be involved in the mechanism of UC. Trial results comparing the probiotic Escherichia coli Nissle 1917 to mesalazine have reported equivalent rates of UC relapse. Treatment with Lactobacillus rhamnosus GG strain alone or in combination with mesalazine resulted in a nonsignificant odds ratio decrease for relapse and a significant increase in time to relapse compared to treatment with mesalazine alone. Additionally, bifidobacteria-fermented milk-supplemented patients had significant reductions in UC exacerbations when compared to nonsupplemented patients. Probiotics were well tolerated, with adverse event rates similar between treatments. CONCLUSIONS: Studies evaluating probiotics for maintaining remission of UC are limited by trial design and use of different probiotics with variable bacterial contents. Thus, questions remain regarding optimal probiotic, dosing, specific patient populations, and placement in therapy. To answer these questions, large, randomized, controlled trials need to be conducted before probiotics can be routinely recommended for maintaining remission of UC. SN - 1542-6270 UR - https://www.unboundmedicine.com/medline/citation/20124461/Probiotics_for_maintaining_remission_of_ulcerative_colitis_in_adults_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1M498?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -