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Intraductal papillary-mucinous neoplasms of the gastric and intestinal types may have less malignant potential than the pancreatobiliary type.
Pancreas 2010; 39(5):604-10P

Abstract

OBJECTIVES

Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas are classified into 4 types--gastric, intestinal, pancreatobiliary, and oncocytic--on the basis of their morphology and immunohistochemistry. We classified IPMNs at our institute and used this classification to determine the clinicopathological features, prognosis, and malignant potential of the 4 types.

METHODS

Sixty-one patients with IPMN who underwent surgery between 2000 and 2007 were evaluated retrospectively.

RESULTS

There were 24 tumors of the gastric type, 22 intestinal, 12 pancreatobiliary, and 3 oncocytic. Patients with the intestinal or gastric type had a better prognosis than those with the pancreatobiliary type. The intestinal and pancreatobiliary types had almost the same frequencies of carcinoma, but the intestinal type tended to have a lower frequency of invasive carcinoma than the pancreatobiliary type. Patients with invasive carcinomas derived from intestinal-type IPMNs tended to have a better prognosis than those whose invasive carcinomas were derived from the pancreatobiliary type.

CONCLUSIONS

Intraductal papillary-mucinous neoplasm of the gastric and intestinal types may have less malignant potential than that of the pancreatobiliary type. Invasive carcinomas derived from intestinal-type IPMNs may be less invasive and slower growing than those derived from the pancreatobiliary type.

Authors+Show Affiliations

Department of Gastroenterological, General, Breast and Thyroid Surgery, Faculty of Medicine, Yamagata University, Yamagata City, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20124938

Citation

Takasu, Naoki, et al. "Intraductal Papillary-mucinous Neoplasms of the Gastric and Intestinal Types May Have Less Malignant Potential Than the Pancreatobiliary Type." Pancreas, vol. 39, no. 5, 2010, pp. 604-10.
Takasu N, Kimura W, Moriya T, et al. Intraductal papillary-mucinous neoplasms of the gastric and intestinal types may have less malignant potential than the pancreatobiliary type. Pancreas. 2010;39(5):604-10.
Takasu, N., Kimura, W., Moriya, T., Hirai, I., Takeshita, A., Kamio, Y., & Nomura, T. (2010). Intraductal papillary-mucinous neoplasms of the gastric and intestinal types may have less malignant potential than the pancreatobiliary type. Pancreas, 39(5), pp. 604-10. doi:10.1097/MPA.0b013e3181c6947a.
Takasu N, et al. Intraductal Papillary-mucinous Neoplasms of the Gastric and Intestinal Types May Have Less Malignant Potential Than the Pancreatobiliary Type. Pancreas. 2010;39(5):604-10. PubMed PMID: 20124938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraductal papillary-mucinous neoplasms of the gastric and intestinal types may have less malignant potential than the pancreatobiliary type. AU - Takasu,Naoki, AU - Kimura,Wataru, AU - Moriya,Toshiyuki, AU - Hirai,Ichiro, AU - Takeshita,Akiko, AU - Kamio,Yukinori, AU - Nomura,Takashi, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/10/12/medline SP - 604 EP - 10 JF - Pancreas JO - Pancreas VL - 39 IS - 5 N2 - OBJECTIVES: Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas are classified into 4 types--gastric, intestinal, pancreatobiliary, and oncocytic--on the basis of their morphology and immunohistochemistry. We classified IPMNs at our institute and used this classification to determine the clinicopathological features, prognosis, and malignant potential of the 4 types. METHODS: Sixty-one patients with IPMN who underwent surgery between 2000 and 2007 were evaluated retrospectively. RESULTS: There were 24 tumors of the gastric type, 22 intestinal, 12 pancreatobiliary, and 3 oncocytic. Patients with the intestinal or gastric type had a better prognosis than those with the pancreatobiliary type. The intestinal and pancreatobiliary types had almost the same frequencies of carcinoma, but the intestinal type tended to have a lower frequency of invasive carcinoma than the pancreatobiliary type. Patients with invasive carcinomas derived from intestinal-type IPMNs tended to have a better prognosis than those whose invasive carcinomas were derived from the pancreatobiliary type. CONCLUSIONS: Intraductal papillary-mucinous neoplasm of the gastric and intestinal types may have less malignant potential than that of the pancreatobiliary type. Invasive carcinomas derived from intestinal-type IPMNs may be less invasive and slower growing than those derived from the pancreatobiliary type. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/20124938/Intraductal_papillary_mucinous_neoplasms_of_the_gastric_and_intestinal_types_may_have_less_malignant_potential_than_the_pancreatobiliary_type_ L2 - http://Insights.ovid.com/pubmed?pmid=20124938 DB - PRIME DP - Unbound Medicine ER -