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The role of alcohol and smoking in pancreatitis.
Nat Rev Gastroenterol Hepatol 2010; 7(3):131-45NR

Abstract

Chronic alcohol use has been linked to chronic pancreatitis for over a century, but it has not been until the last decade that the role of alcohol in chronic pancreatitis has been elucidated in animals and, only in recent years, in human populations. Although a dose-dependent association between alcohol consumption and chronic pancreatitis may exist, a staistical association has been shown only with the consumption of >or=5 alcoholic drinks per day. Smoking also confers a strong, independent and dose-dependent risk of pancreatitis that may be additive or multiplicative when combined with alcohol. Alcohol increases the risk of acute pancreatitis in several ways and, most importantly, changes the immune response to injury. Genetic factors are also important and further studies are needed to clarify the role of gene-environment interactions in pancreatitis. In humans, aggressive interventional counseling against alcohol use may reduce the frequency of recurrent attacks of disease and smoking cessation may help to slow the progression of acute to chronic pancreatitis.

Authors+Show Affiliations

Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Avenue, Pittsburgh, PA 15213, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20125091

Citation

Yadav, Dhiraj, and David C. Whitcomb. "The Role of Alcohol and Smoking in Pancreatitis." Nature Reviews. Gastroenterology & Hepatology, vol. 7, no. 3, 2010, pp. 131-45.
Yadav D, Whitcomb DC. The role of alcohol and smoking in pancreatitis. Nat Rev Gastroenterol Hepatol. 2010;7(3):131-45.
Yadav, D., & Whitcomb, D. C. (2010). The role of alcohol and smoking in pancreatitis. Nature Reviews. Gastroenterology & Hepatology, 7(3), pp. 131-45. doi:10.1038/nrgastro.2010.6.
Yadav D, Whitcomb DC. The Role of Alcohol and Smoking in Pancreatitis. Nat Rev Gastroenterol Hepatol. 2010;7(3):131-45. PubMed PMID: 20125091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of alcohol and smoking in pancreatitis. AU - Yadav,Dhiraj, AU - Whitcomb,David C, Y1 - 2010/02/02/ PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/6/9/medline SP - 131 EP - 45 JF - Nature reviews. Gastroenterology & hepatology JO - Nat Rev Gastroenterol Hepatol VL - 7 IS - 3 N2 - Chronic alcohol use has been linked to chronic pancreatitis for over a century, but it has not been until the last decade that the role of alcohol in chronic pancreatitis has been elucidated in animals and, only in recent years, in human populations. Although a dose-dependent association between alcohol consumption and chronic pancreatitis may exist, a staistical association has been shown only with the consumption of >or=5 alcoholic drinks per day. Smoking also confers a strong, independent and dose-dependent risk of pancreatitis that may be additive or multiplicative when combined with alcohol. Alcohol increases the risk of acute pancreatitis in several ways and, most importantly, changes the immune response to injury. Genetic factors are also important and further studies are needed to clarify the role of gene-environment interactions in pancreatitis. In humans, aggressive interventional counseling against alcohol use may reduce the frequency of recurrent attacks of disease and smoking cessation may help to slow the progression of acute to chronic pancreatitis. SN - 1759-5053 UR - https://www.unboundmedicine.com/medline/citation/20125091/The_role_of_alcohol_and_smoking_in_pancreatitis_ L2 - http://dx.doi.org/10.1038/nrgastro.2010.6 DB - PRIME DP - Unbound Medicine ER -