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Acute effects of coffee on endothelial function in healthy subjects.
Eur J Clin Nutr 2010; 64(5):483-9EJ

Abstract

BACKGROUND/OBJECTIVES

Coffee is the most widely consumed beverage in the world, but its effect on the cardiovascular system has not been fully understood. Coffee contains caffeine and antioxidants, which may influence endothelial function, both of which have not yet been investigated. The objective of this study was to investigate the acute effects of coffee on endothelial function measured by brachial artery flow-mediated dilation (FMD).

SUBJECTS/METHODS

A total of 20 (10 males and 10 females) healthy non-obese subjects underwent a double-blind, crossover study. Subjects ingested one cup of caffeinated (CC) and one cup of decaffeinated (DC) Italian espresso coffee in random order at 5- to 7-day intervals.

RESULTS

Following CC ingestion, FMD decreased progressively and significantly (mean+/-s.e.m.: 0 min, 7.7+/-0.6; 30 min, 6.3+/-0.7; 60 min, 6.0+/-0.8%; ANOVA (analysis of variance), P<0.05), but it did not significantly increase after DC ingestion (0 min, 6.9+/-0.6; 30 min, 8.1+/-0.9; 60 min, 8.5+/-0.9%; P=0.115). Similarly, CC significantly increased both systolic and diastolic blood pressure; this effect was not observed after DC ingestion. Blood glucose concentrations remained unchanged after ingestion of both CC and DC, but insulin (0 min, 15.8+/-0.9; 60 min, 15.0+/-0.8 muU/ml; P<0.05) and C-peptide (0 min, 1.25+/-0.09; 60 min, 1.18+/-0.09 ng/ml; P<0.01) blood concentrations decreased significantly only after CC ingestion.

CONCLUSIONS

CC acutely induced unfavorable cardiovascular effects, especially on endothelial function. In the fasting state, insulin secretion is also likely reduced after CC ingestion. Future studies will determine whether CC has detrimental clinically relevant effects, especially in unhealthy subjects.

Authors+Show Affiliations

Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche; Facoltà di Medicina, University of Palermo, Palermo, Italy. silbus@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20125186

Citation

Buscemi, S, et al. "Acute Effects of Coffee On Endothelial Function in Healthy Subjects." European Journal of Clinical Nutrition, vol. 64, no. 5, 2010, pp. 483-9.
Buscemi S, Verga S, Batsis JA, et al. Acute effects of coffee on endothelial function in healthy subjects. Eur J Clin Nutr. 2010;64(5):483-9.
Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., ... Cerasola, G. (2010). Acute effects of coffee on endothelial function in healthy subjects. European Journal of Clinical Nutrition, 64(5), pp. 483-9. doi:10.1038/ejcn.2010.9.
Buscemi S, et al. Acute Effects of Coffee On Endothelial Function in Healthy Subjects. Eur J Clin Nutr. 2010;64(5):483-9. PubMed PMID: 20125186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of coffee on endothelial function in healthy subjects. AU - Buscemi,S, AU - Verga,S, AU - Batsis,J A, AU - Donatelli,M, AU - Tranchina,M R, AU - Belmonte,S, AU - Mattina,A, AU - Re,A, AU - Cerasola,G, Y1 - 2010/02/03/ PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/10/13/medline SP - 483 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 5 N2 - BACKGROUND/OBJECTIVES: Coffee is the most widely consumed beverage in the world, but its effect on the cardiovascular system has not been fully understood. Coffee contains caffeine and antioxidants, which may influence endothelial function, both of which have not yet been investigated. The objective of this study was to investigate the acute effects of coffee on endothelial function measured by brachial artery flow-mediated dilation (FMD). SUBJECTS/METHODS: A total of 20 (10 males and 10 females) healthy non-obese subjects underwent a double-blind, crossover study. Subjects ingested one cup of caffeinated (CC) and one cup of decaffeinated (DC) Italian espresso coffee in random order at 5- to 7-day intervals. RESULTS: Following CC ingestion, FMD decreased progressively and significantly (mean+/-s.e.m.: 0 min, 7.7+/-0.6; 30 min, 6.3+/-0.7; 60 min, 6.0+/-0.8%; ANOVA (analysis of variance), P<0.05), but it did not significantly increase after DC ingestion (0 min, 6.9+/-0.6; 30 min, 8.1+/-0.9; 60 min, 8.5+/-0.9%; P=0.115). Similarly, CC significantly increased both systolic and diastolic blood pressure; this effect was not observed after DC ingestion. Blood glucose concentrations remained unchanged after ingestion of both CC and DC, but insulin (0 min, 15.8+/-0.9; 60 min, 15.0+/-0.8 muU/ml; P<0.05) and C-peptide (0 min, 1.25+/-0.09; 60 min, 1.18+/-0.09 ng/ml; P<0.01) blood concentrations decreased significantly only after CC ingestion. CONCLUSIONS: CC acutely induced unfavorable cardiovascular effects, especially on endothelial function. In the fasting state, insulin secretion is also likely reduced after CC ingestion. Future studies will determine whether CC has detrimental clinically relevant effects, especially in unhealthy subjects. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20125186/Acute_effects_of_coffee_on_endothelial_function_in_healthy_subjects_ L2 - http://dx.doi.org/10.1038/ejcn.2010.9 DB - PRIME DP - Unbound Medicine ER -