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Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1.
PLoS One. 2010 Feb 01; 5(2):e8987.Plos

Abstract

BACKGROUND

In the event of an influenza pandemic, the majority of people infected will be nursed at home. It is therefore important to determine simple methods for limiting the spread of the virus within the home. The purpose of this work was to test a representative range of common household cleaning agents for their effectiveness at killing or reducing the viability of influenza A virus.

METHODOLOGY/PRINCIPAL FINDINGS

Plaque assays provided a robust and reproducible method for determining virus viability after disinfection, while a National Standard influenza virus RT-PCR assay (VSOP 25, www.hpa-standardmethods.org.uk) was adapted to detect viral genome, and a British Standard (BS:EN 14476:2005) was modified to determine virus killing.

CONCLUSIONS/SIGNIFICANCE

Active ingredients in a number of the cleaning agents, wipes, and tissues tested were able to rapidly render influenza virus nonviable, as determined by plaque assay. Commercially available wipes with a claimed antiviral or antibacterial effect killed or reduced virus infectivity, while nonmicrobiocidal wipes and those containing only low concentrations (<5%) of surfactants showed lower anti-influenza activity. Importantly, however, our findings indicate that it is possible to use common, low-technology agents such as 1% bleach, 10% malt vinegar, or 0.01% washing-up liquid to rapidly and completely inactivate influenza virus. Thus, in the context of the ongoing pandemic, and especially in low-resource settings, the public does not need to source specialized cleaning products, but can rapidly disinfect potentially contaminated surfaces with agents readily available in most homes.

Authors+Show Affiliations

Health Protection Agency, Addenbrookes Hospital, Cambridge, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20126543

Citation

Greatorex, Jane S., et al. "Effectiveness of Common Household Cleaning Agents in Reducing the Viability of Human Influenza A/H1N1." PloS One, vol. 5, no. 2, 2010, pp. e8987.
Greatorex JS, Page RF, Curran MD, et al. Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1. PLoS ONE. 2010;5(2):e8987.
Greatorex, J. S., Page, R. F., Curran, M. D., Digard, P., Enstone, J. E., Wreghitt, T., Powell, P. P., Sexton, D. W., Vivancos, R., & Nguyen-Van-Tam, J. S. (2010). Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1. PloS One, 5(2), e8987. https://doi.org/10.1371/journal.pone.0008987
Greatorex JS, et al. Effectiveness of Common Household Cleaning Agents in Reducing the Viability of Human Influenza A/H1N1. PLoS ONE. 2010 Feb 1;5(2):e8987. PubMed PMID: 20126543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of common household cleaning agents in reducing the viability of human influenza A/H1N1. AU - Greatorex,Jane S, AU - Page,Rosanna F, AU - Curran,Martin D, AU - Digard,Paul, AU - Enstone,Joanne E, AU - Wreghitt,Tim, AU - Powell,Penny P, AU - Sexton,Darren W, AU - Vivancos,Roberto, AU - Nguyen-Van-Tam,Jonathan S, Y1 - 2010/02/01/ PY - 2009/11/25/received PY - 2010/01/12/accepted PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/10/1/medline SP - e8987 EP - e8987 JF - PloS one JO - PLoS ONE VL - 5 IS - 2 N2 - BACKGROUND: In the event of an influenza pandemic, the majority of people infected will be nursed at home. It is therefore important to determine simple methods for limiting the spread of the virus within the home. The purpose of this work was to test a representative range of common household cleaning agents for their effectiveness at killing or reducing the viability of influenza A virus. METHODOLOGY/PRINCIPAL FINDINGS: Plaque assays provided a robust and reproducible method for determining virus viability after disinfection, while a National Standard influenza virus RT-PCR assay (VSOP 25, www.hpa-standardmethods.org.uk) was adapted to detect viral genome, and a British Standard (BS:EN 14476:2005) was modified to determine virus killing. CONCLUSIONS/SIGNIFICANCE: Active ingredients in a number of the cleaning agents, wipes, and tissues tested were able to rapidly render influenza virus nonviable, as determined by plaque assay. Commercially available wipes with a claimed antiviral or antibacterial effect killed or reduced virus infectivity, while nonmicrobiocidal wipes and those containing only low concentrations (<5%) of surfactants showed lower anti-influenza activity. Importantly, however, our findings indicate that it is possible to use common, low-technology agents such as 1% bleach, 10% malt vinegar, or 0.01% washing-up liquid to rapidly and completely inactivate influenza virus. Thus, in the context of the ongoing pandemic, and especially in low-resource settings, the public does not need to source specialized cleaning products, but can rapidly disinfect potentially contaminated surfaces with agents readily available in most homes. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/20126543/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0008987 DB - PRIME DP - Unbound Medicine ER -