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Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats.
Am J Chin Med. 2010; 38(1):75-88.AJ

Abstract

The hepatoprotective and antioxidant effect of an ethanolic extract of 'Rocket' Eruca sativa L. (EER), on liver injury induced by carbon tetrachloride (CCl(4)) was investigated. Wistar albino rats were administered 250 and 500 mg/kg body weight extract orally for 10 consecutive days. Marker enzymes GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Whereas, non-protein sulfhydryl (NP-SH), total protein (TP) and malondialdehyde (MDA) were estimated in liver tissue as markers for oxidative stress. Histopathological assessment was also done on liver tissue. CCl(4) induced liver poisoning in all treated animals was evident by elevated serum GOT, GPT, ALP, GGT and bilirubin levels. Induction of oxidative stress in the liver tissue by CCl(4) was evidenced by a fall in the levels of NP-SH and TP; and an increased level of MDA concentration. EER administration for 10 days prevented the CCl(4) induced hepatic injury and oxidative stress. Furthermore, the extract also reduced the pentobarbital-induced prolongation of sleeping time in mice. The ability of rocket extract to protect the liver toxicity in rats was further confirmed by histological findings in the liver tissue. In conclusion, it was observed that Eruca sativa L. extract protects the liver against CCl(4) induced hepatic injury through its potent antioxidant activity in rats.

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Authors+Show Affiliations

Alqasoumi S
Department of Pharmacognosy and Medicinal, Aromatic and Poisonous Plants Research Center, King Saud University, Riyadh, Saudi Arabia. sqasoumi@ksu.edu.sa

MeSH

AnimalsAntioxidantsBilirubinBiomarkersBrassicaceaeCarbon TetrachlorideCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryFemaleLiverMaleMalondialdehydeMiceOxidative StressPentobarbitalPhytotherapyPlant ExtractsPlant LeavesProteinsRatsRats, Sprague-DawleyRats, WistarSleepSulfhydryl Compounds

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20128046

Citation

Alqasoumi, Saleh. "Carbon Tetrachloride-induced Hepatotoxicity: Protective Effect of 'Rocket' Eruca Sativa L. in Rats." The American Journal of Chinese Medicine, vol. 38, no. 1, 2010, pp. 75-88.
Alqasoumi S. Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats. Am J Chin Med. 2010;38(1):75-88.
Alqasoumi, S. (2010). Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats. The American Journal of Chinese Medicine, 38(1), 75-88.
Alqasoumi S. Carbon Tetrachloride-induced Hepatotoxicity: Protective Effect of 'Rocket' Eruca Sativa L. in Rats. Am J Chin Med. 2010;38(1):75-88. PubMed PMID: 20128046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats. A1 - Alqasoumi,Saleh, PY - 2010/2/4/entrez PY - 2010/2/4/pubmed PY - 2010/4/23/medline SP - 75 EP - 88 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 38 IS - 1 N2 - The hepatoprotective and antioxidant effect of an ethanolic extract of 'Rocket' Eruca sativa L. (EER), on liver injury induced by carbon tetrachloride (CCl(4)) was investigated. Wistar albino rats were administered 250 and 500 mg/kg body weight extract orally for 10 consecutive days. Marker enzymes GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Whereas, non-protein sulfhydryl (NP-SH), total protein (TP) and malondialdehyde (MDA) were estimated in liver tissue as markers for oxidative stress. Histopathological assessment was also done on liver tissue. CCl(4) induced liver poisoning in all treated animals was evident by elevated serum GOT, GPT, ALP, GGT and bilirubin levels. Induction of oxidative stress in the liver tissue by CCl(4) was evidenced by a fall in the levels of NP-SH and TP; and an increased level of MDA concentration. EER administration for 10 days prevented the CCl(4) induced hepatic injury and oxidative stress. Furthermore, the extract also reduced the pentobarbital-induced prolongation of sleeping time in mice. The ability of rocket extract to protect the liver toxicity in rats was further confirmed by histological findings in the liver tissue. In conclusion, it was observed that Eruca sativa L. extract protects the liver against CCl(4) induced hepatic injury through its potent antioxidant activity in rats. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/20128046/Carbon_tetrachloride_induced_hepatotoxicity:_Protective_effect_of_'Rocket'_Eruca_sativa_L__in_rats_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X10007671?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -