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[Inhibitory effect of anluohuaxianwan on experimental hepatic fibrosis in rats].
Zhonghua Gan Zang Bing Za Zhi. 2010 Jan; 18(1):9-12.ZG

Abstract

OBJECTIVE

To investigate the effects of anluohuaqianwan on experimental hepatic fibrosis induced by dimethyl nitrosamine (DMN) in rats.

METHODS

36 male SD rats were randomly dividied into three groups: model group, normal group, anluohuaqianwan group. The rats in the three groups were treated with DMN daily for 4 weeks. The liver function was detected using auto biochemistry analyzer, the serum HA, LN, IV-C, PIIIP were detected by immunoradiometry, the histopathology was observed in the left liver lobe after HE staining, the expression of matrix metalloproteinase-2 (MMP-2) in liver tissue were detected by immunohistochemistry.

RESULTS

The serum levels of ALT, AST, ALP, TP, ALB and the contents of HA, LN, IV-C in model group were significantly increased compared to these in the normal group (P less than 0.01). The serum levels of ALT, AST and the contents of HA in anluohuaqianwan group were significantly lower than those in the model group (P less than 0.01). The liver MMP-2 in the model group was significantly increased compared to that in the normal group (P less than 0.05). The expression of MMP-2 in liver tissue of model group was lower than that in the anluohuaqianwan group (P less than 0.05).

CONCLUSION

Anluohuaqianwan can inhibit liver fibrosis in rats induced by DMN.

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Publisher Full Text

Authors+Show Affiliations

Tan XH
Department of Liver Diseases, the Eighth People's Hospital of Guangzhou, Guangzhou 510060,China.
Li CQ
No affiliation info available
Zou SR
No affiliation info available
Xie M
No affiliation info available
Zhang AM
No affiliation info available
Li WL
No affiliation info available
Li XY
No affiliation info available
Huang HF
No affiliation info available
Lei CL
No affiliation info available

MeSH

Alanine TransaminaseAnimalsAspartate AminotransferasesDimethylnitrosamineDrug CombinationsDrugs, Chinese HerbalHyaluronic AcidHydroxyprolineImmunohistochemistryLiverLiver Cirrhosis, ExperimentalLiver Function TestsMaleMatrix Metalloproteinase 2Plants, MedicinalRandom AllocationRatsRats, Sprague-Dawley

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20128961

Citation

Tan, Xing-Hua, et al. "[Inhibitory Effect of Anluohuaxianwan On Experimental Hepatic Fibrosis in Rats]." Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, vol. 18, no. 1, 2010, pp. 9-12.
Tan XH, Li CQ, Zou SR, et al. [Inhibitory effect of anluohuaxianwan on experimental hepatic fibrosis in rats]. Zhonghua Gan Zang Bing Za Zhi. 2010;18(1):9-12.
Tan, X. H., Li, C. Q., Zou, S. R., Xie, M., Zhang, A. M., Li, W. L., Li, X. Y., Huang, H. F., & Lei, C. L. (2010). [Inhibitory effect of anluohuaxianwan on experimental hepatic fibrosis in rats]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology, 18(1), 9-12. https://doi.org/10.3760/cma.j.issn.1007-3418.2010.01.003
Tan XH, et al. [Inhibitory Effect of Anluohuaxianwan On Experimental Hepatic Fibrosis in Rats]. Zhonghua Gan Zang Bing Za Zhi. 2010;18(1):9-12. PubMed PMID: 20128961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibitory effect of anluohuaxianwan on experimental hepatic fibrosis in rats]. AU - Tan,Xing-Hua, AU - Li,Chang-Qing, AU - Zou,Shang-Rong, AU - Xie,Min, AU - Zhang,Ai-Min, AU - Li,Wen-Li, AU - Li,Xiao-Yue, AU - Huang,Hui-Fen, AU - Lei,Chun-Liang, PY - 2010/2/5/entrez PY - 2010/2/5/pubmed PY - 2010/12/22/medline SP - 9 EP - 12 JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology JO - Zhonghua Gan Zang Bing Za Zhi VL - 18 IS - 1 N2 - OBJECTIVE: To investigate the effects of anluohuaqianwan on experimental hepatic fibrosis induced by dimethyl nitrosamine (DMN) in rats. METHODS: 36 male SD rats were randomly dividied into three groups: model group, normal group, anluohuaqianwan group. The rats in the three groups were treated with DMN daily for 4 weeks. The liver function was detected using auto biochemistry analyzer, the serum HA, LN, IV-C, PIIIP were detected by immunoradiometry, the histopathology was observed in the left liver lobe after HE staining, the expression of matrix metalloproteinase-2 (MMP-2) in liver tissue were detected by immunohistochemistry. RESULTS: The serum levels of ALT, AST, ALP, TP, ALB and the contents of HA, LN, IV-C in model group were significantly increased compared to these in the normal group (P less than 0.01). The serum levels of ALT, AST and the contents of HA in anluohuaqianwan group were significantly lower than those in the model group (P less than 0.01). The liver MMP-2 in the model group was significantly increased compared to that in the normal group (P less than 0.05). The expression of MMP-2 in liver tissue of model group was lower than that in the anluohuaqianwan group (P less than 0.05). CONCLUSION: Anluohuaqianwan can inhibit liver fibrosis in rats induced by DMN. SN - 1007-3418 UR - https://www.unboundmedicine.com/medline/citation/20128961/[Inhibitory_effect_of_anluohuaxianwan_on_experimental_hepatic_fibrosis_in_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1007-3418&year=2010&vol=18&issue=1&fpage=9 DB - PRIME DP - Unbound Medicine ER -