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Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug.
J Colloid Interface Sci. 2010 May 01; 345(1):46-53.JC

Abstract

Zein is an alcohol soluble protein of corn origin that exhibits hydrophobic properties. Pseudolatexes are colloidal dispersions containing spherical solid or semisolid particles less than 1 microm in diameter and can be prepared from any existing thermoplastic water-insoluble polymer. The novel plasticized film-coating pseudolatex of zein was studied in formulation of sustained-release tablets containing very water-soluble drug. Film formation of plasticized aqueous dispersion was compared with film forming properties of plasticized organic solvent system (ethanol) of zein. The water vapor permeability (WVP), water uptake and erosion, and moisture sorption were evaluated with free films. The tablets containing metoprolol tartrate as a model drug were used in pan-coating experiments. Aqueous film coatings plasticized with PEG 400 exhibited very low water uptake. No significant difference in WVP, moisture sorption and erosion were found between aqueous films and organic solvent-based films of zein plasticized with PEG 400. The atomic force microscopy (AFM) images on microstructure of films showed that colloidal particle size of zein in the aqueous films was smaller than that observed in the solvent-based films. In addition, the aqueous-based films were more compact and smoother than the respective solvent-based films. The aqueous zein-coated tablets containing very water-soluble drug (metoprolol tartrate) exhibited clear sustained-release dissolution profiles in vitro, while the respective solvent-based film-coated tablets showed much faster drug release. Furthermore, aqueous zein-coated tablets had lower water absorption at high humidity conditions. In conclusion, the plasticized aqueous dispersion (pseudolatex) of zein can be used for moisture resistant film coating of sustained-release tablets containing very water-soluble drug.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy, Shandong University, 250012 Jinan, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20129615

Citation

Li, X N., et al. "Aqueous Coating Dispersion (pseudolatex) of Zein Improves Formulation of Sustained-release Tablets Containing Very Water-soluble Drug." Journal of Colloid and Interface Science, vol. 345, no. 1, 2010, pp. 46-53.
Li XN, Guo HX, Heinamaki J. Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug. J Colloid Interface Sci. 2010;345(1):46-53.
Li, X. N., Guo, H. X., & Heinamaki, J. (2010). Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug. Journal of Colloid and Interface Science, 345(1), 46-53. https://doi.org/10.1016/j.jcis.2010.01.029
Li XN, Guo HX, Heinamaki J. Aqueous Coating Dispersion (pseudolatex) of Zein Improves Formulation of Sustained-release Tablets Containing Very Water-soluble Drug. J Colloid Interface Sci. 2010 May 1;345(1):46-53. PubMed PMID: 20129615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug. AU - Li,X N, AU - Guo,H X, AU - Heinamaki,J, Y1 - 2010/01/18/ PY - 2009/10/27/received PY - 2010/01/10/revised PY - 2010/01/13/accepted PY - 2010/2/5/entrez PY - 2010/2/5/pubmed PY - 2010/6/4/medline SP - 46 EP - 53 JF - Journal of colloid and interface science JO - J Colloid Interface Sci VL - 345 IS - 1 N2 - Zein is an alcohol soluble protein of corn origin that exhibits hydrophobic properties. Pseudolatexes are colloidal dispersions containing spherical solid or semisolid particles less than 1 microm in diameter and can be prepared from any existing thermoplastic water-insoluble polymer. The novel plasticized film-coating pseudolatex of zein was studied in formulation of sustained-release tablets containing very water-soluble drug. Film formation of plasticized aqueous dispersion was compared with film forming properties of plasticized organic solvent system (ethanol) of zein. The water vapor permeability (WVP), water uptake and erosion, and moisture sorption were evaluated with free films. The tablets containing metoprolol tartrate as a model drug were used in pan-coating experiments. Aqueous film coatings plasticized with PEG 400 exhibited very low water uptake. No significant difference in WVP, moisture sorption and erosion were found between aqueous films and organic solvent-based films of zein plasticized with PEG 400. The atomic force microscopy (AFM) images on microstructure of films showed that colloidal particle size of zein in the aqueous films was smaller than that observed in the solvent-based films. In addition, the aqueous-based films were more compact and smoother than the respective solvent-based films. The aqueous zein-coated tablets containing very water-soluble drug (metoprolol tartrate) exhibited clear sustained-release dissolution profiles in vitro, while the respective solvent-based film-coated tablets showed much faster drug release. Furthermore, aqueous zein-coated tablets had lower water absorption at high humidity conditions. In conclusion, the plasticized aqueous dispersion (pseudolatex) of zein can be used for moisture resistant film coating of sustained-release tablets containing very water-soluble drug. SN - 1095-7103 UR - https://www.unboundmedicine.com/medline/citation/20129615/Aqueous_coating_dispersion__pseudolatex__of_zein_improves_formulation_of_sustained_release_tablets_containing_very_water_soluble_drug_ DB - PRIME DP - Unbound Medicine ER -