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Scrub typhus in previously unrecognized areas of endemicity in China.
J Clin Microbiol. 2010 Apr; 48(4):1241-4.JC

Abstract

Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past.

Authors+Show Affiliations

State Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, China Centers for Disease Control and Prevention, Beijing 102206, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20129967

Citation

Zhang, Shouyin, et al. "Scrub Typhus in Previously Unrecognized Areas of Endemicity in China." Journal of Clinical Microbiology, vol. 48, no. 4, 2010, pp. 1241-4.
Zhang S, Song H, Liu Y, et al. Scrub typhus in previously unrecognized areas of endemicity in China. J Clin Microbiol. 2010;48(4):1241-4.
Zhang, S., Song, H., Liu, Y., Li, Q., Wang, Y., Wu, J., Wan, J., Li, G., Yu, C., Li, X., Yin, W., Xu, Z., Liu, B., Zhang, Q., Wan, K., Li, G., Fu, X., Zhang, J., He, J., ... Yu, X. J. (2010). Scrub typhus in previously unrecognized areas of endemicity in China. Journal of Clinical Microbiology, 48(4), 1241-4. https://doi.org/10.1128/JCM.01784-09
Zhang S, et al. Scrub Typhus in Previously Unrecognized Areas of Endemicity in China. J Clin Microbiol. 2010;48(4):1241-4. PubMed PMID: 20129967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub typhus in previously unrecognized areas of endemicity in China. AU - Zhang,Shouyin, AU - Song,Hongbin, AU - Liu,Yan, AU - Li,Qun, AU - Wang,Yong, AU - Wu,Jiabin, AU - Wan,Junfeng, AU - Li,Guolan, AU - Yu,Changjun, AU - Li,Xiuyong, AU - Yin,Wenwu, AU - Xu,Zhen, AU - Liu,Bo, AU - Zhang,Qian, AU - Wan,Kanglin, AU - Li,Guichang, AU - Fu,Xiuping, AU - Zhang,Jingshan, AU - He,Jinrong, AU - Hai,Rong, AU - Yu,Dongzheng, AU - Walker,David H, AU - Xu,Jianguo, AU - Yu,Xue-Jie, Y1 - 2010/02/03/ PY - 2010/2/5/entrez PY - 2010/2/5/pubmed PY - 2010/6/16/medline SP - 1241 EP - 4 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 48 IS - 4 N2 - Scrub typhus, caused by Orientia tsutsugamushi, has emerged recently in areas of northern China where the disease had not been known to exist. We analyzed epidemiological, clinical, and laboratory data for 104 patients who were admitted to a hospital in Fuyang City between 26 September and 1 November 2008. We showed that the major clinical manifestations of the patients were fever (100%), headache (82%), myalgias (77%), eschar (67%), rash (52%), and unusual facial flushing (62%). Among the 104 patients, the sera of 98% contained IgM antibodies to O. tsutsugamushi detected by indirect immunofluorescence assays (IFA), and DNA of the O. tsutsugamushi 56-kDa gene was amplified by PCR from the blood of 36 patients. We conclude that 104 patients were infected with scrub typhus in Fuyang City, Anhui Province. Our study indicates that physicians need to consider the diagnosis of scrub typhus for febrile patients living in northern China, where scrub typhus had not been considered to exist in the past. SN - 1098-660X UR - https://www.unboundmedicine.com/medline/citation/20129967/Scrub_typhus_in_previously_unrecognized_areas_of_endemicity_in_China_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=20129967 DB - PRIME DP - Unbound Medicine ER -