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[Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis with Wilms tumor].
Arkh Patol. 2009 Nov-Dec; 71(6):41-3.AP

Abstract

There may be a number of tumors made up by small round blue cells in the kidneys of children. One of them is primitive neuroectodermal tumor (PNET). The differences in therapeutic approaches determine the need to establish an accurate diagnosis. The differential diagnosis of PNET and the blastemal component of Wilms tumor can be difficult due to the similar histological pattern. There is a need for a close analysis of morphological manifestations, by keeping in mind the age of patients, and supplementary studies. A strong CD99 membrane expression and nuclear FLI1 expression in tumor cells are the signs of PNET. Reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization can determine PNET-specific translocations [t(11;22)(q24;q12), by involving the EWS gene.

Authors

Popov SD
No affiliation info available
Sebire NJ
No affiliation info available
Popova ED
No affiliation info available
Vujanic GM
No affiliation info available

MeSH

12E7 AntigenAntigens, CDCell Adhesion MoleculesChildChild, PreschoolChromosomes, Human, Pair 11Chromosomes, Human, Pair 22Diagnosis, DifferentialFemaleGene Expression Regulation, NeoplasticHumansKidney NeoplasmsMaleNeuroectodermal Tumors, PrimitiveProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSTranslocation, GeneticWilms Tumor

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

20131507

Citation

Popov, S D., et al. "[Primitive Neuroectodermal Tumor of the Kidney in Children; Its Differential Diagnosis With Wilms Tumor]." Arkhiv Patologii, vol. 71, no. 6, 2009, pp. 41-3.
Popov SD, Sebire NJ, Popova ED, et al. [Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis with Wilms tumor]. Arkh Patol. 2009;71(6):41-3.
Popov, S. D., Sebire, N. J., Popova, E. D., & Vujanic, G. M. (2009). [Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis with Wilms tumor]. Arkhiv Patologii, 71(6), 41-3.
Popov SD, et al. [Primitive Neuroectodermal Tumor of the Kidney in Children; Its Differential Diagnosis With Wilms Tumor]. Arkh Patol. 2009 Nov-Dec;71(6):41-3. PubMed PMID: 20131507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Primitive neuroectodermal tumor of the kidney in children; its differential diagnosis with Wilms tumor]. AU - Popov,S D, AU - Sebire,N J, AU - Popova,E D, AU - Vujanic,G M, PY - 2010/2/6/entrez PY - 2010/2/6/pubmed PY - 2010/4/1/medline SP - 41 EP - 3 JF - Arkhiv patologii JO - Arkh Patol VL - 71 IS - 6 N2 - There may be a number of tumors made up by small round blue cells in the kidneys of children. One of them is primitive neuroectodermal tumor (PNET). The differences in therapeutic approaches determine the need to establish an accurate diagnosis. The differential diagnosis of PNET and the blastemal component of Wilms tumor can be difficult due to the similar histological pattern. There is a need for a close analysis of morphological manifestations, by keeping in mind the age of patients, and supplementary studies. A strong CD99 membrane expression and nuclear FLI1 expression in tumor cells are the signs of PNET. Reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization can determine PNET-specific translocations [t(11;22)(q24;q12), by involving the EWS gene. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/20131507/[Primitive_neuroectodermal_tumor_of_the_kidney_in_children L2 - https://medlineplus.gov/kidneycancer.html DB - PRIME DP - Unbound Medicine ER -