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Comparative molecular analysis of meticillin-resistant Staphylococcus aureus isolates from children with atopic dermatitis and healthy subjects in Taiwan.
Br J Dermatol. 2010 May; 162(5):1110-6.BJ

Abstract

BACKGROUND

Children with atopic dermatitis (AD) are more frequently colonized by Staphylococcus aureus than healthy children.

OBJECTIVES

To assess whether any relationship exists between nasal meticillin-resistant S. aureus (MRSA) colonization and subsequent skin and soft-tissue infections (SSTI).

PATIENTS AND METHODS

From 2005 through 2006, comparative molecular analyses of 23 MRSA-colonizing isolates from 133 children with AD, 44 MRSA-colonizing isolates from 490 healthy controls, and 12 MRSA-infecting isolates from 20 children with AD and concurrent SSTI were conducted.

RESULTS

Nasal MRSA colonization in children with AD was significantly higher compared with normal individuals (17.3% vs. 9.0%; P = 0.01). The molecular characteristics differed significantly between the MRSA isolates from children with AD and the MRSA-colonizing isolates from healthy controls. The clone characterized as sequence type (ST)59 (338)/pulsotype B/staphylococcal cassette chromosome mec (SCCmec) V(T)/Panton-Valentine leucocidin (PVL)-positive/staphylococcal enterotoxin B (SEB)-positive accounted for half of the MRSA isolates from children with AD, and another clone, characterized as ST59/pulsotype A/SCCmec IV/PVL-negative/SEB-positive accounted for 61% of the MRSA-colonizing isolates from healthy controls.

CONCLUSIONS

We found MRSA colonizing the anterior nares of a large number of Taiwanese children, especially among those with AD. Analysis of our data provides evidence that links MRSA-colonizing isolates to MRSA-infecting isolates from concurrent SSTI in children with AD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lo WT
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Section 2, Nei-hu 114, Taipei, Taiwan.
Wang SR
No affiliation info available
Tseng MH
No affiliation info available
Huang CF
No affiliation info available
Chen SJ
No affiliation info available
Wang CC
No affiliation info available

MeSH

AdolescentBacterial ToxinsBacterial Typing TechniquesChildChild, PreschoolDermatitis, AtopicExotoxinsFemaleGenes, BacterialGenotypeHumansInfantInfant, NewbornLeukocidinsMaleMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsNasal CavitySoft Tissue InfectionsStaphylococcal InfectionsStaphylococcal Skin Infections

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20132206

Citation

Lo, W-T, et al. "Comparative Molecular Analysis of Meticillin-resistant Staphylococcus Aureus Isolates From Children With Atopic Dermatitis and Healthy Subjects in Taiwan." The British Journal of Dermatology, vol. 162, no. 5, 2010, pp. 1110-6.
Lo WT, Wang SR, Tseng MH, et al. Comparative molecular analysis of meticillin-resistant Staphylococcus aureus isolates from children with atopic dermatitis and healthy subjects in Taiwan. Br J Dermatol. 2010;162(5):1110-6.
Lo, W. T., Wang, S. R., Tseng, M. H., Huang, C. F., Chen, S. J., & Wang, C. C. (2010). Comparative molecular analysis of meticillin-resistant Staphylococcus aureus isolates from children with atopic dermatitis and healthy subjects in Taiwan. The British Journal of Dermatology, 162(5), 1110-6. https://doi.org/10.1111/j.1365-2133.2010.09679.x
Lo WT, et al. Comparative Molecular Analysis of Meticillin-resistant Staphylococcus Aureus Isolates From Children With Atopic Dermatitis and Healthy Subjects in Taiwan. Br J Dermatol. 2010;162(5):1110-6. PubMed PMID: 20132206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative molecular analysis of meticillin-resistant Staphylococcus aureus isolates from children with atopic dermatitis and healthy subjects in Taiwan. AU - Lo,W-T, AU - Wang,S-R, AU - Tseng,M-H, AU - Huang,C-F, AU - Chen,S-J, AU - Wang,C-C, Y1 - 2010/02/03/ PY - 2010/2/6/entrez PY - 2010/2/6/pubmed PY - 2010/6/29/medline SP - 1110 EP - 6 JF - The British journal of dermatology JO - Br J Dermatol VL - 162 IS - 5 N2 - BACKGROUND: Children with atopic dermatitis (AD) are more frequently colonized by Staphylococcus aureus than healthy children. OBJECTIVES: To assess whether any relationship exists between nasal meticillin-resistant S. aureus (MRSA) colonization and subsequent skin and soft-tissue infections (SSTI). PATIENTS AND METHODS: From 2005 through 2006, comparative molecular analyses of 23 MRSA-colonizing isolates from 133 children with AD, 44 MRSA-colonizing isolates from 490 healthy controls, and 12 MRSA-infecting isolates from 20 children with AD and concurrent SSTI were conducted. RESULTS: Nasal MRSA colonization in children with AD was significantly higher compared with normal individuals (17.3% vs. 9.0%; P = 0.01). The molecular characteristics differed significantly between the MRSA isolates from children with AD and the MRSA-colonizing isolates from healthy controls. The clone characterized as sequence type (ST)59 (338)/pulsotype B/staphylococcal cassette chromosome mec (SCCmec) V(T)/Panton-Valentine leucocidin (PVL)-positive/staphylococcal enterotoxin B (SEB)-positive accounted for half of the MRSA isolates from children with AD, and another clone, characterized as ST59/pulsotype A/SCCmec IV/PVL-negative/SEB-positive accounted for 61% of the MRSA-colonizing isolates from healthy controls. CONCLUSIONS: We found MRSA colonizing the anterior nares of a large number of Taiwanese children, especially among those with AD. Analysis of our data provides evidence that links MRSA-colonizing isolates to MRSA-infecting isolates from concurrent SSTI in children with AD. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/20132206/Comparative_molecular_analysis_of_meticillin_resistant_Staphylococcus_aureus_isolates_from_children_with_atopic_dermatitis_and_healthy_subjects_in_Taiwan_ DB - PRIME DP - Unbound Medicine ER -
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