Tags

Type your tag names separated by a space and hit enter

Comparative study of the nucleotide bias between the novel H1N1 and H5N1 subtypes of influenza A viruses using bioinformatics techniques.
J Microbiol Biotechnol 2010; 20(1):63-70JM

Abstract

Novel influenza A (H1N1) is a newly emerged flu virus which was first detected in April, 2009. Unlike the avian influenza (H5N1), this virus has been known to be able to spread from human to human directly. Although it is uncertain that how severe this novel H1N1 virus will be in terms of human illness, illness may be more widespread because most people will not have immunity to it. In this study, we compared the codon usage bias between the novel H1N1 influenza A viruses and other viruses such as H1N1 and H5N1 subtypes to investigate the genomic patterns of novel influenza A (H1N1). Totally 1,675 nucleotide sequences of the hemagglutinin (HA) and neuraminidase (NA) genes of influenza A virus including H1N1 and H5N1 subtypes occurred from 2004 to 2009 were used. As a result, we found that the novel H1N1 influenza A viruses showed the most close correlations with the swine-origin H1N1 subtypes than other H1N1 viruses in the result from not only the analysis of nucleotide compositions, but also the phylogenetic analysis. Although the genetic sequences of novel H1N1 subtypes were not exactly same as the other H1N1 subtypes, the HA and NA genes of novel H1N1s showed very similar codon usage patterns with other H1N1 subtypes, especially with the swine-origin H1N1 influenza A viruses. Our findings strongly suggested that those novel H1N1 viruses seemed to be originated from the swine-host H1N1 viruses in terms of the codon usage patterns.

Authors+Show Affiliations

Korea Institute of Science and Technology Information, Daejon, Korea.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20134234

Citation

Ahn, Insung, and Hyeon Seok Son. "Comparative Study of the Nucleotide Bias Between the Novel H1N1 and H5N1 Subtypes of Influenza a Viruses Using Bioinformatics Techniques." Journal of Microbiology and Biotechnology, vol. 20, no. 1, 2010, pp. 63-70.
Ahn I, Son HS. Comparative study of the nucleotide bias between the novel H1N1 and H5N1 subtypes of influenza A viruses using bioinformatics techniques. J Microbiol Biotechnol. 2010;20(1):63-70.
Ahn, I., & Son, H. S. (2010). Comparative study of the nucleotide bias between the novel H1N1 and H5N1 subtypes of influenza A viruses using bioinformatics techniques. Journal of Microbiology and Biotechnology, 20(1), pp. 63-70.
Ahn I, Son HS. Comparative Study of the Nucleotide Bias Between the Novel H1N1 and H5N1 Subtypes of Influenza a Viruses Using Bioinformatics Techniques. J Microbiol Biotechnol. 2010;20(1):63-70. PubMed PMID: 20134234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of the nucleotide bias between the novel H1N1 and H5N1 subtypes of influenza A viruses using bioinformatics techniques. AU - Ahn,Insung, AU - Son,Hyeon Seok, PY - 2010/2/6/entrez PY - 2010/2/6/pubmed PY - 2010/4/28/medline SP - 63 EP - 70 JF - Journal of microbiology and biotechnology JO - J. Microbiol. Biotechnol. VL - 20 IS - 1 N2 - Novel influenza A (H1N1) is a newly emerged flu virus which was first detected in April, 2009. Unlike the avian influenza (H5N1), this virus has been known to be able to spread from human to human directly. Although it is uncertain that how severe this novel H1N1 virus will be in terms of human illness, illness may be more widespread because most people will not have immunity to it. In this study, we compared the codon usage bias between the novel H1N1 influenza A viruses and other viruses such as H1N1 and H5N1 subtypes to investigate the genomic patterns of novel influenza A (H1N1). Totally 1,675 nucleotide sequences of the hemagglutinin (HA) and neuraminidase (NA) genes of influenza A virus including H1N1 and H5N1 subtypes occurred from 2004 to 2009 were used. As a result, we found that the novel H1N1 influenza A viruses showed the most close correlations with the swine-origin H1N1 subtypes than other H1N1 viruses in the result from not only the analysis of nucleotide compositions, but also the phylogenetic analysis. Although the genetic sequences of novel H1N1 subtypes were not exactly same as the other H1N1 subtypes, the HA and NA genes of novel H1N1s showed very similar codon usage patterns with other H1N1 subtypes, especially with the swine-origin H1N1 influenza A viruses. Our findings strongly suggested that those novel H1N1 viruses seemed to be originated from the swine-host H1N1 viruses in terms of the codon usage patterns. SN - 1017-7825 UR - https://www.unboundmedicine.com/medline/citation/20134234/Comparative_study_of_the_nucleotide_bias_between_the_novel_H1N1_and_H5N1_subtypes_of_influenza_A_viruses_using_bioinformatics_techniques_ L2 - http://www.jmb.or.kr/journal/viewJournal.html?year=2010&vol=20&num=1&page=63 DB - PRIME DP - Unbound Medicine ER -