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Measures of overweight and obesity and risk of cardiovascular disease: a population-based study.
Eur J Cardiovasc Prev Rehabil 2010; 17(4):486-90EJ

Abstract

BACKGROUND

Although overweight and obesity are associated with cardiovascular disease (CVD), it is unclear which clinical measure of overweight and obesity is the strongest predictor of CVD, and it is unclear whether the various measures of overweight and obesity are indeed independent predictors of CVD.

METHODS

This study was a prospective population-based study of 2493 Danish men and women, age 41-72 years, without major CVD at baseline. At baseline, body mass index, waist circumference, hip circumference, waist-to-hip ratio (WHR), and traditional and new risk factors were recorded.

RESULTS

Over a median follow-up of 12.6 years, the incidence of a combined CV event (CV death, nonfatal ischemic heart disease, and nonfatal stroke) amounted to 328 cases. Of the various measures of overweight and obesity, in Cox-proportional hazard models, adjusted for age, only WHR was significantly associated with incident CVD with a hazard ratio (95% confidence interval) in women of 2.22 (1.31-3.77; P=0.0032) in the highest compared with the lowest quartile, and a hazard ratio in men of 1.73 (1.12-2.66; P=0.014) in the highest compared with the lowest quartile. However, when adjustments were made for the presence of diabetes, dyslipidemia, hypertension, hyperinsulinemia, and inflammation, WHR was no longer significantly (P>0.41) associated with incident CVD.

CONCLUSION

In this study, of the various measures of overweight and obesity, WHR was the only significant predictor of incident CVD, and the relationship between WHR and risk of CVD was mediated by well-known risk factors of CVD.

Authors+Show Affiliations

Department of Medicine, Glostrup Hospital, Glostrup, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20134327

Citation

Sehested, Thomas S G., et al. "Measures of Overweight and Obesity and Risk of Cardiovascular Disease: a Population-based Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 17, no. 4, 2010, pp. 486-90.
Sehested TS, Hansen TW, Olsen MH, et al. Measures of overweight and obesity and risk of cardiovascular disease: a population-based study. Eur J Cardiovasc Prev Rehabil. 2010;17(4):486-90.
Sehested, T. S., Hansen, T. W., Olsen, M. H., Abildstrøm, S. Z., Rasmussen, S., Ibsen, H., ... Jeppesen, J. (2010). Measures of overweight and obesity and risk of cardiovascular disease: a population-based study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 17(4), pp. 486-90. doi:10.1097/HJR.0b013e3283373f63.
Sehested TS, et al. Measures of Overweight and Obesity and Risk of Cardiovascular Disease: a Population-based Study. Eur J Cardiovasc Prev Rehabil. 2010;17(4):486-90. PubMed PMID: 20134327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measures of overweight and obesity and risk of cardiovascular disease: a population-based study. AU - Sehested,Thomas S G, AU - Hansen,Tine W, AU - Olsen,Michael H, AU - Abildstrøm,Steen Z, AU - Rasmussen,Susanne, AU - Ibsen,Hans, AU - Torp-Pedersen,Christian, AU - Madsbad,Sten, AU - Jeppesen,Jørgen, PY - 2010/2/6/entrez PY - 2010/2/6/pubmed PY - 2010/11/16/medline SP - 486 EP - 90 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 17 IS - 4 N2 - BACKGROUND: Although overweight and obesity are associated with cardiovascular disease (CVD), it is unclear which clinical measure of overweight and obesity is the strongest predictor of CVD, and it is unclear whether the various measures of overweight and obesity are indeed independent predictors of CVD. METHODS: This study was a prospective population-based study of 2493 Danish men and women, age 41-72 years, without major CVD at baseline. At baseline, body mass index, waist circumference, hip circumference, waist-to-hip ratio (WHR), and traditional and new risk factors were recorded. RESULTS: Over a median follow-up of 12.6 years, the incidence of a combined CV event (CV death, nonfatal ischemic heart disease, and nonfatal stroke) amounted to 328 cases. Of the various measures of overweight and obesity, in Cox-proportional hazard models, adjusted for age, only WHR was significantly associated with incident CVD with a hazard ratio (95% confidence interval) in women of 2.22 (1.31-3.77; P=0.0032) in the highest compared with the lowest quartile, and a hazard ratio in men of 1.73 (1.12-2.66; P=0.014) in the highest compared with the lowest quartile. However, when adjustments were made for the presence of diabetes, dyslipidemia, hypertension, hyperinsulinemia, and inflammation, WHR was no longer significantly (P>0.41) associated with incident CVD. CONCLUSION: In this study, of the various measures of overweight and obesity, WHR was the only significant predictor of incident CVD, and the relationship between WHR and risk of CVD was mediated by well-known risk factors of CVD. SN - 1741-8275 UR - https://www.unboundmedicine.com/medline/citation/20134327/Measures_of_overweight_and_obesity_and_risk_of_cardiovascular_disease:_a_population_based_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=20134327.ui DB - PRIME DP - Unbound Medicine ER -