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Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.
South Med J 2010; 103(3):265-7SM

Abstract

Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy.

Authors+Show Affiliations

Southside Endocrinology and Division of Diabetes, Endocrinology, and Metabolism, University of Alabama Medical School, Birmingham, AL 35205, USA. dshbell@yahoo.com

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20134380

Citation

Bell, David S H.. "Metformin-induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy." Southern Medical Journal, vol. 103, no. 3, 2010, pp. 265-7.
Bell DS. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J. 2010;103(3):265-7.
Bell, D. S. (2010). Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. Southern Medical Journal, 103(3), pp. 265-7. doi:10.1097/SMJ.0b013e3181ce0e4d.
Bell DS. Metformin-induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy. South Med J. 2010;103(3):265-7. PubMed PMID: 20134380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. A1 - Bell,David S H, PY - 2010/2/6/entrez PY - 2010/2/6/pubmed PY - 2010/4/21/medline SP - 265 EP - 7 JF - Southern medical journal JO - South. Med. J. VL - 103 IS - 3 N2 - Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy. SN - 1541-8243 UR - https://www.unboundmedicine.com/medline/citation/20134380/full_citation L2 - http://dx.doi.org/10.1097/SMJ.0b013e3181ce0e4d DB - PRIME DP - Unbound Medicine ER -