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pH-sensitive magnetic alginate-chitosan beads for albendazole delivery.
Pharm Dev Technol. 2011 Jun; 16(3):228-36.PD

Abstract

Novel magnetic alginate-chitosan beads were prepared for the controlled delivery of albendazole. The magnetic beads were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and vibrating sample magnetometry (VSM). The swelling behavior and in vitro release of albendazole from the beads has been investigated. The magnetic hydrogel beads had showed unique pH-dependent swelling behaviors and a continuous release of the entrapped albendazole occurred. From the magnetometer measurements data, the magnetic alginate-chitosan beads also had superparamagnetic property as well as fast magnetic response. The magnetic beads may be used as a magnetic drug targeting system for albendazole in the gastrointestinal tract.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang FQ
The Second Hospital of Lanzhou University, Lanzhou, PR China.
Li P
No affiliation info available
Zhang JP
No affiliation info available
Wang AQ
No affiliation info available
Wei Q
No affiliation info available

MeSH

AlbendazoleAlginatesAntiprotozoal AgentsChitosanDrug CarriersDrug Delivery SystemsGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateHydrogen-Ion ConcentrationMagneticsMagnetite NanoparticlesMicroscopy, Electron, ScanningMicrospheresSpectroscopy, Fourier Transform InfraredTechnology, Pharmaceutical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20136349

Citation

Wang, Fa-Qin, et al. "PH-sensitive Magnetic Alginate-chitosan Beads for Albendazole Delivery." Pharmaceutical Development and Technology, vol. 16, no. 3, 2011, pp. 228-36.
Wang FQ, Li P, Zhang JP, et al. PH-sensitive magnetic alginate-chitosan beads for albendazole delivery. Pharm Dev Technol. 2011;16(3):228-36.
Wang, F. Q., Li, P., Zhang, J. P., Wang, A. Q., & Wei, Q. (2011). PH-sensitive magnetic alginate-chitosan beads for albendazole delivery. Pharmaceutical Development and Technology, 16(3), 228-36. https://doi.org/10.3109/10837451003592217
Wang FQ, et al. PH-sensitive Magnetic Alginate-chitosan Beads for Albendazole Delivery. Pharm Dev Technol. 2011;16(3):228-36. PubMed PMID: 20136349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - pH-sensitive magnetic alginate-chitosan beads for albendazole delivery. AU - Wang,Fa-Qin, AU - Li,Ping, AU - Zhang,Jun-Ping, AU - Wang,Ai-Qin, AU - Wei,Qin, Y1 - 2010/02/05/ PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2011/10/1/medline SP - 228 EP - 36 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 16 IS - 3 N2 - Novel magnetic alginate-chitosan beads were prepared for the controlled delivery of albendazole. The magnetic beads were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and vibrating sample magnetometry (VSM). The swelling behavior and in vitro release of albendazole from the beads has been investigated. The magnetic hydrogel beads had showed unique pH-dependent swelling behaviors and a continuous release of the entrapped albendazole occurred. From the magnetometer measurements data, the magnetic alginate-chitosan beads also had superparamagnetic property as well as fast magnetic response. The magnetic beads may be used as a magnetic drug targeting system for albendazole in the gastrointestinal tract. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20136349/pH_sensitive_magnetic_alginate_chitosan_beads_for_albendazole_delivery_ DB - PRIME DP - Unbound Medicine ER -