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Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups.
Curr Eye Res. 2010 Feb; 35(2):122-9.CE

Abstract

PURPOSE

The present study was aimed at investigating the possible antioxidant potential of curcumin at a dose of 75 mg/kg body weight on selenite-induced cataract in experimental rat pups.

METHODS

Group I: Control rat pups receiving physiological saline; Group II: Selenite-induced group (15 microM/kg body wt); Group III: Selenite-induced group co-treated with curcumin (single dose of curcumin orally 75 mg/kg body wt); Group IV: Selenite-induced animals post-treated (after 24 hrs) with curcumin at a dose mentioned for group III; Group V: Rat pups were pretreated with curcumin (dose as mentioned in Group III), 24 hrs before the administration of selenite. Encapsulated lenses liver, kidney, and serum were analyzed for antioxidant enzymes and malondialdehyde, a marker of lipid peroxidation.

RESULTS

Intraperitoneal injection of sodium selenite (15 microM/kg body wt) to 8-10-day-old rat pups led to severe oxidative stress in eye lens as evidenced by enhanced LPO levels that led to cataract formation. Sodium selenite also led to decrease in activities of SOD, GST, GPx, CAT with simultaneous decrease in the levels of GSH, vitamin C, and vitamin E. Treatment with curcumin (75 mg/kg body wt) led to a significant decrease in the levels of LPO, enzymic antioxidants, and nonenzymic antioxidants, which were similar to that of control.

CONCLUSIONS

Curcumin suppressed selenite-induced oxidative stress and cataract formation in rat pups. The presence of oxidative stress in selenite cataract development and its prevention by curcumin support the possibility that the natural consumption of curcumin in food can help prevent the onset of senile cataract.

Authors+Show Affiliations

Unit of Pathobiology, Department of Zoology, University of Madras, Guindy Campus, Chennai, India. manikandanramar@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20136422

Citation

Manikandan, R, et al. "Effect of Curcumin On Selenite-induced Cataractogenesis in Wistar Rat Pups." Current Eye Research, vol. 35, no. 2, 2010, pp. 122-9.
Manikandan R, Thiagarajan R, Beulaja S, et al. Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. Curr Eye Res. 2010;35(2):122-9.
Manikandan, R., Thiagarajan, R., Beulaja, S., Sudhandiran, G., & Arumugam, M. (2010). Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. Current Eye Research, 35(2), 122-9. https://doi.org/10.3109/02713680903447884
Manikandan R, et al. Effect of Curcumin On Selenite-induced Cataractogenesis in Wistar Rat Pups. Curr Eye Res. 2010;35(2):122-9. PubMed PMID: 20136422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. AU - Manikandan,R, AU - Thiagarajan,R, AU - Beulaja,S, AU - Sudhandiran,G, AU - Arumugam,M, PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/4/17/medline SP - 122 EP - 9 JF - Current eye research JO - Curr Eye Res VL - 35 IS - 2 N2 - PURPOSE: The present study was aimed at investigating the possible antioxidant potential of curcumin at a dose of 75 mg/kg body weight on selenite-induced cataract in experimental rat pups. METHODS: Group I: Control rat pups receiving physiological saline; Group II: Selenite-induced group (15 microM/kg body wt); Group III: Selenite-induced group co-treated with curcumin (single dose of curcumin orally 75 mg/kg body wt); Group IV: Selenite-induced animals post-treated (after 24 hrs) with curcumin at a dose mentioned for group III; Group V: Rat pups were pretreated with curcumin (dose as mentioned in Group III), 24 hrs before the administration of selenite. Encapsulated lenses liver, kidney, and serum were analyzed for antioxidant enzymes and malondialdehyde, a marker of lipid peroxidation. RESULTS: Intraperitoneal injection of sodium selenite (15 microM/kg body wt) to 8-10-day-old rat pups led to severe oxidative stress in eye lens as evidenced by enhanced LPO levels that led to cataract formation. Sodium selenite also led to decrease in activities of SOD, GST, GPx, CAT with simultaneous decrease in the levels of GSH, vitamin C, and vitamin E. Treatment with curcumin (75 mg/kg body wt) led to a significant decrease in the levels of LPO, enzymic antioxidants, and nonenzymic antioxidants, which were similar to that of control. CONCLUSIONS: Curcumin suppressed selenite-induced oxidative stress and cataract formation in rat pups. The presence of oxidative stress in selenite cataract development and its prevention by curcumin support the possibility that the natural consumption of curcumin in food can help prevent the onset of senile cataract. SN - 1460-2202 UR - https://www.unboundmedicine.com/medline/citation/20136422/Effect_of_curcumin_on_selenite_induced_cataractogenesis_in_Wistar_rat_pups_ L2 - https://www.tandfonline.com/doi/full/10.3109/02713680903447884 DB - PRIME DP - Unbound Medicine ER -