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[Analysis of prognostic factors influencing the outcome of intrahepatic cholangiocarcinoma].
Zhonghua Zhong Liu Za Zhi. 2009 Nov; 31(11):845-8.ZZ

Abstract

OBJECTIVE

To analyze the clinicopathologic factors influencing the outcome of surgically treated intrahepatic cholangiocarcinoma (ICC) and to explore the proper treatment choice of ICC.

METHODS

The clinicopathological data of 43 surgically treated ICC patients in our hospital were retrospectively analyzed. Of the 43 patients, hepatic resection was performed in 40 patients, ethanol injection in 2, and laparoscopic exploration alone in 1. Kaplan-Meier method and Cox regression model were used for the analysis of factors influencing survival after operation.

RESULTS

The accumulative 1-, 3- and 5-year survival rates were 64.4%, 30.9%, 25.8% for the whole group, and 74.7%, 33.3%, 27.8% for the 40 patients with hepatic resection, respectively. Univariate analysis revealed that tumor size, carcinoembryonic antigen (CEA) level, lymph node involvement and TNM stage were factors significantly affecting the survival (P < 0.05). Cox multivariate analysis demonstrated that only tumor size and lymph node involvement were the independent factors significantly affecting the survival (P < 0.05).

CONCLUSION

Our results show that tumor size and lymph node involvement are independent factors affecting the survival. CEA level and TNM stage are important prognostic factors for surgical management. Radical resection is still the optimal treatment for patient with intrahepatic cholangiocarcinoma.

Authors+Show Affiliations

Department of Abdominal Surgical Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20137350

Citation

Zhang, Lei, et al. "[Analysis of Prognostic Factors Influencing the Outcome of Intrahepatic Cholangiocarcinoma]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 31, no. 11, 2009, pp. 845-8.
Zhang L, Cai JQ, Bi XY, et al. [Analysis of prognostic factors influencing the outcome of intrahepatic cholangiocarcinoma]. Zhonghua Zhong Liu Za Zhi. 2009;31(11):845-8.
Zhang, L., Cai, J. Q., Bi, X. Y., Zhao, J. J., Xing, G. S., Yan, T., Fu, Y. X., & Zhao, P. (2009). [Analysis of prognostic factors influencing the outcome of intrahepatic cholangiocarcinoma]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 31(11), 845-8.
Zhang L, et al. [Analysis of Prognostic Factors Influencing the Outcome of Intrahepatic Cholangiocarcinoma]. Zhonghua Zhong Liu Za Zhi. 2009;31(11):845-8. PubMed PMID: 20137350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of prognostic factors influencing the outcome of intrahepatic cholangiocarcinoma]. AU - Zhang,Lei, AU - Cai,Jian-qiang, AU - Bi,Xin-yu, AU - Zhao,Jian-jun, AU - Xing,Gu-sheng, AU - Yan,Tao, AU - Fu,Yu-xia, AU - Zhao,Ping, PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/12/14/medline SP - 845 EP - 8 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 31 IS - 11 N2 - OBJECTIVE: To analyze the clinicopathologic factors influencing the outcome of surgically treated intrahepatic cholangiocarcinoma (ICC) and to explore the proper treatment choice of ICC. METHODS: The clinicopathological data of 43 surgically treated ICC patients in our hospital were retrospectively analyzed. Of the 43 patients, hepatic resection was performed in 40 patients, ethanol injection in 2, and laparoscopic exploration alone in 1. Kaplan-Meier method and Cox regression model were used for the analysis of factors influencing survival after operation. RESULTS: The accumulative 1-, 3- and 5-year survival rates were 64.4%, 30.9%, 25.8% for the whole group, and 74.7%, 33.3%, 27.8% for the 40 patients with hepatic resection, respectively. Univariate analysis revealed that tumor size, carcinoembryonic antigen (CEA) level, lymph node involvement and TNM stage were factors significantly affecting the survival (P < 0.05). Cox multivariate analysis demonstrated that only tumor size and lymph node involvement were the independent factors significantly affecting the survival (P < 0.05). CONCLUSION: Our results show that tumor size and lymph node involvement are independent factors affecting the survival. CEA level and TNM stage are important prognostic factors for surgical management. Radical resection is still the optimal treatment for patient with intrahepatic cholangiocarcinoma. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/20137350/[Analysis_of_prognostic_factors_influencing_the_outcome_of_intrahepatic_cholangiocarcinoma]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-3766&amp;year=2009&amp;vol=31&amp;issue=11&amp;fpage=845 DB - PRIME DP - Unbound Medicine ER -