Tags

Type your tag names separated by a space and hit enter

[Resistance study of community respiratory pathogens isolated in China from 2005 to 2007].
Zhonghua Yi Xue Za Zhi. 2009 Nov 17; 89(42):2983-7.ZY

Abstract

OBJECTIVE

To investigate the antimicrobial resistance of community respiratory pathogens isolated in China.

METHODS

The strains of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, S. pyogenes were isolated from patients with community-acquired respiratory tract infections at 14 Chinese hospitals from 2005 to 2007. Etest and disk diffusion methods were used to survey the susceptibility of 14 antibiotics against these strains. These antibiotics included penicillin G, ampicillin, amoxicillin/clavulanic acid, cefaclor, cefprozil, ceftriaxone, cefepime, levofloxacin, gatifloxacin, ciprofloxacin, tetracycline, clindamycin, erythromycin and trimethoprim/sulfamethoxazole (SXT).

RESULTS

A total of 1870 strains were collected including S. pneumoniae (n = 997), S. pyogenes (n = 176), H. influenzae (n = 499) and M. catarrhalis (n = 198). The 2005 - 2007 prevalence of penicillin-susceptible S. pneumoniae (PSSP) were 92.6%, 73.9%, 74.1% and penicillin-intermediate S. pneumoniae (PISP) 4.5%, 9.5%, 14.3% and penicillin-resistant S. pneumoniae (PRSP) 2.9%, 16.6%, 11.6% respectively. 36.9% of S. pneumoniae strains isolated from <or= 6 years old children were penicillin-non-susceptive isolates (PNSSP) and < 22.0% of PNSSP isolated from other age groups. The susceptible rates of beta-lactamase antibiotics to PRSP and PISP isolates were less than 25.0% and 49.2% respectively. From 48.5% to 98.6% PSSP isolates were susceptible to beta-lactamase antibiotics. The susceptible rates of PNSSP and PSSP to erythromycin, tetracycline and SXT were below 7.1% and 32.1% respectively. About 95% S. pneumoniae were susceptible to ciprofloxacin, levofloxacin and gatifloxacin. All of S. pyogenes isolates were susceptible to beta-lactamase antibiotics, and 16.7%, 27.1% and 15.6% Of S. pyogenes isolates were susceptible to erythromycin. 8.5%, 19.9%, 15.3% of H. influenzae and 57.4%, 78.8%, 95.5% of M. catarrhalis produced beta-lactamase during the 3-year period. The susceptible rates of cefepime, ceftriaxone, gatifloxacin, levofloxacin and ciprofloxacin to H. influenzae and M. catarrhalis were >or= 92.9%.

CONCLUSIONS

Antimicrobial resistance in S. pneumoniae is rising. The prevalence of PNSSP isolated from children < or = 6 years old is higher than other age groups. Amoxicillin-clavulanic acid, ceftriaxone, cefepime, gatifloxacin and levofloxacin remain highly active against common community respiratory pathogens.

Authors+Show Affiliations

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

20137709

Citation

Sun, Hong-li, et al. "[Resistance Study of Community Respiratory Pathogens Isolated in China From 2005 to 2007]." Zhonghua Yi Xue Za Zhi, vol. 89, no. 42, 2009, pp. 2983-7.
Sun HL, Yang QW, Xu YC, et al. [Resistance study of community respiratory pathogens isolated in China from 2005 to 2007]. Zhonghua Yi Xue Za Zhi. 2009;89(42):2983-7.
Sun, H. L., Yang, Q. W., Xu, Y. C., Wang, H., Xie, X. L., Chen, M. J., Zhang, X. Z., Liu, Y., Ye, H. F., Sun, Z. Y., Duan, Q., Ni, Y. X., Yu, Y. S., Zhao, W. S., He, L., Wang, J., Ji, P., Liu, P. P., & Zhang, L. X. (2009). [Resistance study of community respiratory pathogens isolated in China from 2005 to 2007]. Zhonghua Yi Xue Za Zhi, 89(42), 2983-7.
Sun HL, et al. [Resistance Study of Community Respiratory Pathogens Isolated in China From 2005 to 2007]. Zhonghua Yi Xue Za Zhi. 2009 Nov 17;89(42):2983-7. PubMed PMID: 20137709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Resistance study of community respiratory pathogens isolated in China from 2005 to 2007]. AU - Sun,Hong-li, AU - Yang,Qi-wen, AU - Xu,Ying-chun, AU - Wang,Hui, AU - Xie,Xiu-li, AU - Chen,Min-jun, AU - Zhang,Xiu-zhen, AU - Liu,Yong, AU - Ye,Hui-fen, AU - Sun,Zi-yong, AU - Duan,Qiong, AU - Ni,Yu-xing, AU - Yu,Yun-song, AU - Zhao,Wang-sheng, AU - He,Lin, AU - Wang,Jing, AU - Ji,Ping, AU - Liu,Peng-peng, AU - Zhang,Li-xia, PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/5/19/medline SP - 2983 EP - 7 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 89 IS - 42 N2 - OBJECTIVE: To investigate the antimicrobial resistance of community respiratory pathogens isolated in China. METHODS: The strains of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, S. pyogenes were isolated from patients with community-acquired respiratory tract infections at 14 Chinese hospitals from 2005 to 2007. Etest and disk diffusion methods were used to survey the susceptibility of 14 antibiotics against these strains. These antibiotics included penicillin G, ampicillin, amoxicillin/clavulanic acid, cefaclor, cefprozil, ceftriaxone, cefepime, levofloxacin, gatifloxacin, ciprofloxacin, tetracycline, clindamycin, erythromycin and trimethoprim/sulfamethoxazole (SXT). RESULTS: A total of 1870 strains were collected including S. pneumoniae (n = 997), S. pyogenes (n = 176), H. influenzae (n = 499) and M. catarrhalis (n = 198). The 2005 - 2007 prevalence of penicillin-susceptible S. pneumoniae (PSSP) were 92.6%, 73.9%, 74.1% and penicillin-intermediate S. pneumoniae (PISP) 4.5%, 9.5%, 14.3% and penicillin-resistant S. pneumoniae (PRSP) 2.9%, 16.6%, 11.6% respectively. 36.9% of S. pneumoniae strains isolated from <or= 6 years old children were penicillin-non-susceptive isolates (PNSSP) and < 22.0% of PNSSP isolated from other age groups. The susceptible rates of beta-lactamase antibiotics to PRSP and PISP isolates were less than 25.0% and 49.2% respectively. From 48.5% to 98.6% PSSP isolates were susceptible to beta-lactamase antibiotics. The susceptible rates of PNSSP and PSSP to erythromycin, tetracycline and SXT were below 7.1% and 32.1% respectively. About 95% S. pneumoniae were susceptible to ciprofloxacin, levofloxacin and gatifloxacin. All of S. pyogenes isolates were susceptible to beta-lactamase antibiotics, and 16.7%, 27.1% and 15.6% Of S. pyogenes isolates were susceptible to erythromycin. 8.5%, 19.9%, 15.3% of H. influenzae and 57.4%, 78.8%, 95.5% of M. catarrhalis produced beta-lactamase during the 3-year period. The susceptible rates of cefepime, ceftriaxone, gatifloxacin, levofloxacin and ciprofloxacin to H. influenzae and M. catarrhalis were >or= 92.9%. CONCLUSIONS: Antimicrobial resistance in S. pneumoniae is rising. The prevalence of PNSSP isolated from children < or = 6 years old is higher than other age groups. Amoxicillin-clavulanic acid, ceftriaxone, cefepime, gatifloxacin and levofloxacin remain highly active against common community respiratory pathogens. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/20137709/[Resistance_study_of_community_respiratory_pathogens_isolated_in_China_from_2005_to_2007]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2009&amp;vol=89&amp;issue=42&amp;fpage=2983 DB - PRIME DP - Unbound Medicine ER -