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Infundibulomatosis: a case report with immunohistochemical study and literature review.
Dermatol Online J. 2010 Jan 15; 16(1):14.DO

Abstract

Tumor of the follicular infundibulum was first described in 1961 by Mehregan and Butler in a patient presenting with multiple papules. It is more frequent, however, as an isolated lesion affecting mainly the face, neck, and upper trunk. Clinical presentation is variable, requiring histology for the diagnosis, which reveals typically a plate-like proliferation of keratinocytes in continuity with the epidermis and hair follicles; some morphological features are reminiscent of the outer root sheath of the hair follicle. A well defined network of elastic fibers surrounding the tumor is usually present using the appropriate staining and this finding is specific because it is not found in other benign follicular tumors. Multiple infundibulomas are usually sporadic and there is no apparent association with internal malignancy. The authors report the case of a 30-year-old female patient with a 5-year history of multiple small discrete hypopigmented macules and papules, scattered over the submental and submaxillary regions and anterior neck. Histopathological findings were consistent with the diagnosis of tumor of the follicular infundibulum. Immunohistochemical study was performed to further characterize the proliferation.

Authors+Show Affiliations

University Hospital of Coimbra, Dermatology Department, Coimbra, Portugal. ze_carlos_cardoso@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

20137756

Citation

Cardoso, José Carolos, et al. "Infundibulomatosis: a Case Report With Immunohistochemical Study and Literature Review." Dermatology Online Journal, vol. 16, no. 1, 2010, p. 14.
Cardoso JC, Reis JP, Figueiredo P, et al. Infundibulomatosis: a case report with immunohistochemical study and literature review. Dermatol Online J. 2010;16(1):14.
Cardoso, J. C., Reis, J. P., Figueiredo, P., & Tellechea, O. (2010). Infundibulomatosis: a case report with immunohistochemical study and literature review. Dermatology Online Journal, 16(1), 14.
Cardoso JC, et al. Infundibulomatosis: a Case Report With Immunohistochemical Study and Literature Review. Dermatol Online J. 2010 Jan 15;16(1):14. PubMed PMID: 20137756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infundibulomatosis: a case report with immunohistochemical study and literature review. AU - Cardoso,José Carolos, AU - Reis,José Pedro, AU - Figueiredo,Paulo, AU - Tellechea,Oscar, Y1 - 2010/01/15/ PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/4/24/medline SP - 14 EP - 14 JF - Dermatology online journal JO - Dermatol. Online J. VL - 16 IS - 1 N2 - Tumor of the follicular infundibulum was first described in 1961 by Mehregan and Butler in a patient presenting with multiple papules. It is more frequent, however, as an isolated lesion affecting mainly the face, neck, and upper trunk. Clinical presentation is variable, requiring histology for the diagnosis, which reveals typically a plate-like proliferation of keratinocytes in continuity with the epidermis and hair follicles; some morphological features are reminiscent of the outer root sheath of the hair follicle. A well defined network of elastic fibers surrounding the tumor is usually present using the appropriate staining and this finding is specific because it is not found in other benign follicular tumors. Multiple infundibulomas are usually sporadic and there is no apparent association with internal malignancy. The authors report the case of a 30-year-old female patient with a 5-year history of multiple small discrete hypopigmented macules and papules, scattered over the submental and submaxillary regions and anterior neck. Histopathological findings were consistent with the diagnosis of tumor of the follicular infundibulum. Immunohistochemical study was performed to further characterize the proliferation. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/20137756/Infundibulomatosis:_a_case_report_with_immunohistochemical_study_and_literature_review_ L2 - https://medlineplus.gov/headandneckcancer.html DB - PRIME DP - Unbound Medicine ER -