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Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy.
Diabetes Metab 2010; 36(2):152-7DM

Abstract

AIMS

Advanced glycation end products (AGEs) are thought to play a central role in the pathogenesis of diabetes complications. For this reason, a non-invasive tool using skin autofluorescence (AF) quantification that correlates with levels of tissue AGEs has been developed. The present study aimed to assess whether or not skin AF is associated with microvascular complications in patients with type 1 diabetes (T1D).

METHODS

All consecutive patients with T1D (n=133) had three AF measures taken on the forearm, using illumination with a fluorescent tube, all on the same day after breakfast or lunch. Potential associations between skin AF levels and microvascular complications, age, diabetes duration and health status were then assessed using a multivariate linear-regression model.

RESULTS

On age-adjusted analyses, diabetes duration, retinopathy, nephropathy and neuropathy were significantly associated with skin AF levels (all P<0.001). AF levels increased significantly with severity in both retinopathy and nephropathy (P<0.001). After adjusting for age, diabetes duration, HbA(1c), smoking, retinopathy, nephropathy and neuropathy, the association of AF levels remained significant with nephropathy and neuropathy, but not with retinopathy and diabetes duration.

CONCLUSION

This study suggests an independent association between skin AF levels and diabetic nephropathy and neuropathy, but not retinopathy, in T1D patients. Prospective studies are needed to confirm the ability of skin AF levels to predict microangiopathy.

Authors+Show Affiliations

Endocrinology Department, Edouard Herriot Hospital, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20137994

Citation

Chabroux, S, et al. "Advanced Glycation End Products Assessed By Skin Autofluorescence in Type 1 Diabetics Are Associated With Nephropathy, but Not Retinopathy." Diabetes & Metabolism, vol. 36, no. 2, 2010, pp. 152-7.
Chabroux S, Canouï-Poitrine F, Reffet S, et al. Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy. Diabetes Metab. 2010;36(2):152-7.
Chabroux, S., Canouï-Poitrine, F., Reffet, S., Mills-Joncour, G., Morelon, E., Colin, C., & Thivolet, C. (2010). Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy. Diabetes & Metabolism, 36(2), pp. 152-7. doi:10.1016/j.diabet.2009.11.003.
Chabroux S, et al. Advanced Glycation End Products Assessed By Skin Autofluorescence in Type 1 Diabetics Are Associated With Nephropathy, but Not Retinopathy. Diabetes Metab. 2010;36(2):152-7. PubMed PMID: 20137994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy. AU - Chabroux,S, AU - Canouï-Poitrine,F, AU - Reffet,S, AU - Mills-Joncour,G, AU - Morelon,E, AU - Colin,C, AU - Thivolet,C, Y1 - 2010/02/06/ PY - 2009/08/28/received PY - 2009/11/03/revised PY - 2009/11/08/accepted PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/8/3/medline SP - 152 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 36 IS - 2 N2 - AIMS: Advanced glycation end products (AGEs) are thought to play a central role in the pathogenesis of diabetes complications. For this reason, a non-invasive tool using skin autofluorescence (AF) quantification that correlates with levels of tissue AGEs has been developed. The present study aimed to assess whether or not skin AF is associated with microvascular complications in patients with type 1 diabetes (T1D). METHODS: All consecutive patients with T1D (n=133) had three AF measures taken on the forearm, using illumination with a fluorescent tube, all on the same day after breakfast or lunch. Potential associations between skin AF levels and microvascular complications, age, diabetes duration and health status were then assessed using a multivariate linear-regression model. RESULTS: On age-adjusted analyses, diabetes duration, retinopathy, nephropathy and neuropathy were significantly associated with skin AF levels (all P<0.001). AF levels increased significantly with severity in both retinopathy and nephropathy (P<0.001). After adjusting for age, diabetes duration, HbA(1c), smoking, retinopathy, nephropathy and neuropathy, the association of AF levels remained significant with nephropathy and neuropathy, but not with retinopathy and diabetes duration. CONCLUSION: This study suggests an independent association between skin AF levels and diabetic nephropathy and neuropathy, but not retinopathy, in T1D patients. Prospective studies are needed to confirm the ability of skin AF levels to predict microangiopathy. SN - 1878-1780 UR - https://www.unboundmedicine.com/medline/citation/20137994/Advanced_glycation_end_products_assessed_by_skin_autofluorescence_in_type_1_diabetics_are_associated_with_nephropathy_but_not_retinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1262-3636(10)00005-4 DB - PRIME DP - Unbound Medicine ER -