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The role of cognitive impairment in general functioning in major depression.
Psychiatry Res 2010; 176(2-3):183-9PR

Abstract

The association between cognitive performance and general functioning in depression is controversial. The present study evaluated the association between cognitive dysfunction and major depressive disorder (MDD, N=70) as compared with age- and gender-matched healthy controls (n=206) and its relationship to general functioning (physical and mental health quality of life, activities of daily living, and employment status) in participants with current MDD (n=26) and those with previous MDD only (n=44). Participants were assessed clinically using the Mini International Neuropsychiatric Interview (M.I.N.I.) for the depression groups and the Diagnostic Interview for Psychoses (DIP-DM) for the control group. Measures to evaluate cognition and quality of lifes comprised the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Short Form-36 Health Survey Questionnaire, and the Activities/Instrumental Activities of Daily Living (ADL/IADL); employment status was also assessed in MDD. The results showed that a) while individuals with current depression had worse cognitive performance in all domains than healthy controls, those individuals with previous depression had lasting cognitive impairments in the domains of immediate memory and attention as compared with healthy controls; b) individuals with current depression had lower scores in the visuospatial/constructional and attention domains and the total score than individuals with previous depression; c) individuals in the depression group as a whole who were currently unemployed had significantly lower scores in all domains (except attention) of cognitive function; d) cognitive function was not related to either physical or mental quality of life or impairments of activities of daily living (ADL, IADL); e) that unemployment in previous depression was related to poor cognitive function similar to those with current depression. The results indicate that MDD may have detrimental and lasting effects on cognitive performance partly related to poorer general functioning.

Authors+Show Affiliations

Psychiatry and Psychiatric Neuroscience, School of Medicine and Dentistry, James Cook University, Townsville 4811, Australia. bernhard.baune@jcu.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20138370

Citation

Baune, Bernhard T., et al. "The Role of Cognitive Impairment in General Functioning in Major Depression." Psychiatry Research, vol. 176, no. 2-3, 2010, pp. 183-9.
Baune BT, Miller R, McAfoose J, et al. The role of cognitive impairment in general functioning in major depression. Psychiatry Res. 2010;176(2-3):183-9.
Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., & Mitchell, D. (2010). The role of cognitive impairment in general functioning in major depression. Psychiatry Research, 176(2-3), pp. 183-9. doi:10.1016/j.psychres.2008.12.001.
Baune BT, et al. The Role of Cognitive Impairment in General Functioning in Major Depression. Psychiatry Res. 2010 Apr 30;176(2-3):183-9. PubMed PMID: 20138370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of cognitive impairment in general functioning in major depression. AU - Baune,Bernhard T, AU - Miller,Robyn, AU - McAfoose,Jordan, AU - Johnson,Melissa, AU - Quirk,Frances, AU - Mitchell,David, PY - 2008/10/20/received PY - 2008/12/05/accepted PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/5/15/medline SP - 183 EP - 9 JF - Psychiatry research JO - Psychiatry Res VL - 176 IS - 2-3 N2 - The association between cognitive performance and general functioning in depression is controversial. The present study evaluated the association between cognitive dysfunction and major depressive disorder (MDD, N=70) as compared with age- and gender-matched healthy controls (n=206) and its relationship to general functioning (physical and mental health quality of life, activities of daily living, and employment status) in participants with current MDD (n=26) and those with previous MDD only (n=44). Participants were assessed clinically using the Mini International Neuropsychiatric Interview (M.I.N.I.) for the depression groups and the Diagnostic Interview for Psychoses (DIP-DM) for the control group. Measures to evaluate cognition and quality of lifes comprised the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Short Form-36 Health Survey Questionnaire, and the Activities/Instrumental Activities of Daily Living (ADL/IADL); employment status was also assessed in MDD. The results showed that a) while individuals with current depression had worse cognitive performance in all domains than healthy controls, those individuals with previous depression had lasting cognitive impairments in the domains of immediate memory and attention as compared with healthy controls; b) individuals with current depression had lower scores in the visuospatial/constructional and attention domains and the total score than individuals with previous depression; c) individuals in the depression group as a whole who were currently unemployed had significantly lower scores in all domains (except attention) of cognitive function; d) cognitive function was not related to either physical or mental quality of life or impairments of activities of daily living (ADL, IADL); e) that unemployment in previous depression was related to poor cognitive function similar to those with current depression. The results indicate that MDD may have detrimental and lasting effects on cognitive performance partly related to poorer general functioning. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/20138370/The_role_of_cognitive_impairment_in_general_functioning_in_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(08)00436-8 DB - PRIME DP - Unbound Medicine ER -