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Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth.
Nestle Nutr Workshop Ser Pediatr Program. 2010; 65:123-33; discussion 133-6.NN

Abstract

There has been intense interest in the role of the n-3 long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA, 22:6n-3), in growth and development of infants. In 2009, there are at least twelve published randomized controlled trials (RCT) assessing the effects of LCPUFA supplementation of infant formula for preterm infants and seventeen RCTs involving formula-fed term infants. In addition, at least five RCTs have investigated the effect of DHA supplementation during pregnancy and/or lactation on infant and early child development. Collectively, the published literature has demonstrated no harm of dietary LCPUFA for infants regardless of whether they are born preterm or at term. However, developmental benefit is more consistently observed in infants born preterm. This may be explained by the fact that DHA accretion to neural tissues peaks during the fetal brain growth spurt in the last trimester of pregnancy. Infants born preterm are denied the full gestation period to accumulate DHA and are at risk of incomplete DHA accumulation. New research is focused on the timing and dose of DHA supplementation needed to optimize developmental outcomes.

Authors+Show Affiliations

Women's and Children's Health Research Institute and University of Adelaide, S.A., Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20139678

Citation

Makrides, Maria, et al. "Role of Long-chain Polyunsaturated Fatty Acids in Neurodevelopment and Growth." Nestle Nutrition Workshop Series. Paediatric Programme, vol. 65, 2010, pp. 123-33; discussion 133-6.
Makrides M, Smithers LG, Gibson RA. Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:123-33; discussion 133-6.
Makrides, M., Smithers, L. G., & Gibson, R. A. (2010). Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. Nestle Nutrition Workshop Series. Paediatric Programme, 65, 123-33; discussion 133-6. https://doi.org/10.1159/000281154
Makrides M, Smithers LG, Gibson RA. Role of Long-chain Polyunsaturated Fatty Acids in Neurodevelopment and Growth. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:123-33; discussion 133-6. PubMed PMID: 20139678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. AU - Makrides,Maria, AU - Smithers,Lisa G, AU - Gibson,Robert A, Y1 - 2010/02/01/ PY - 2010/2/9/entrez PY - 2010/2/9/pubmed PY - 2010/6/9/medline SP - 123-33; discussion 133-6 JF - Nestle Nutrition workshop series. Paediatric programme JO - Nestle Nutr Workshop Ser Pediatr Program VL - 65 N2 - There has been intense interest in the role of the n-3 long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA, 22:6n-3), in growth and development of infants. In 2009, there are at least twelve published randomized controlled trials (RCT) assessing the effects of LCPUFA supplementation of infant formula for preterm infants and seventeen RCTs involving formula-fed term infants. In addition, at least five RCTs have investigated the effect of DHA supplementation during pregnancy and/or lactation on infant and early child development. Collectively, the published literature has demonstrated no harm of dietary LCPUFA for infants regardless of whether they are born preterm or at term. However, developmental benefit is more consistently observed in infants born preterm. This may be explained by the fact that DHA accretion to neural tissues peaks during the fetal brain growth spurt in the last trimester of pregnancy. Infants born preterm are denied the full gestation period to accumulate DHA and are at risk of incomplete DHA accumulation. New research is focused on the timing and dose of DHA supplementation needed to optimize developmental outcomes. SN - 1661-6677 UR - https://www.unboundmedicine.com/medline/citation/20139678/Role_of_long_chain_polyunsaturated_fatty_acids_in_neurodevelopment_and_growth_ L2 - https://www.karger.com?DOI=10.1159/000281154 DB - PRIME DP - Unbound Medicine ER -