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No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year.
J Intern Med. 2010 May; 267(5):462-72.JI

Abstract

BACKGROUND AND AIM

Cross-sectional studies indicate vitamin D to be of importance for glucose tolerance, blood pressure and serum lipids, but whether supplementation with vitamin D would improve cardio-vascular risk factors is not known.

DESIGN AND SETTING

The study was a 1 year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway from November 2005 to October 2007. Subjects. A total of 438 overweight or obese subjects, 21-70 years old, were included and 330 completed the study.

INTERVENTIONS

The subjects were randomized to vitamin D (cholecalciferol, vitamin D(3)) 40 000 IU per week (DD group), vitamin D 20 000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily.

MAIN OUTCOME MEASURES

Fasting serum lipids and blood pressure were measured and an oral glucose tolerance test performed at start and end of the study.

RESULTS

At baseline the mean serum 25(OH)D levels were 58 nmol L(-1) (all subjects) and increased to 140 and 101 nmol L(-1) in the DD and DP groups, respectively. No significant differences were found between the three groups regarding change in measures of glucose metabolism or serum lipids. In the DP group, there was a slight but significant increase in systolic blood pressure compared with the placebo group.

CONCLUSIONS

Our results do not support a positive effect of vitamin D on glucose tolerance, blood pressure or serum lipids. Further studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed.

Authors+Show Affiliations

Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. rolf.jorde@unn.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20141565

Citation

Jorde, R, et al. "No Improvement in Cardiovascular Risk Factors in Overweight and Obese Subjects After Supplementation With Vitamin D3 for 1 Year." Journal of Internal Medicine, vol. 267, no. 5, 2010, pp. 462-72.
Jorde R, Sneve M, Torjesen P, et al. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010;267(5):462-72.
Jorde, R., Sneve, M., Torjesen, P., & Figenschau, Y. (2010). No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. Journal of Internal Medicine, 267(5), 462-72. https://doi.org/10.1111/j.1365-2796.2009.02181.x
Jorde R, et al. No Improvement in Cardiovascular Risk Factors in Overweight and Obese Subjects After Supplementation With Vitamin D3 for 1 Year. J Intern Med. 2010;267(5):462-72. PubMed PMID: 20141565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. AU - Jorde,R, AU - Sneve,M, AU - Torjesen,P, AU - Figenschau,Y, Y1 - 2009/10/19/ PY - 2010/2/10/entrez PY - 2010/2/10/pubmed PY - 2010/6/15/medline SP - 462 EP - 72 JF - Journal of internal medicine JO - J. Intern. Med. VL - 267 IS - 5 N2 - BACKGROUND AND AIM: Cross-sectional studies indicate vitamin D to be of importance for glucose tolerance, blood pressure and serum lipids, but whether supplementation with vitamin D would improve cardio-vascular risk factors is not known. DESIGN AND SETTING: The study was a 1 year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway from November 2005 to October 2007. Subjects. A total of 438 overweight or obese subjects, 21-70 years old, were included and 330 completed the study. INTERVENTIONS: The subjects were randomized to vitamin D (cholecalciferol, vitamin D(3)) 40 000 IU per week (DD group), vitamin D 20 000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily. MAIN OUTCOME MEASURES: Fasting serum lipids and blood pressure were measured and an oral glucose tolerance test performed at start and end of the study. RESULTS: At baseline the mean serum 25(OH)D levels were 58 nmol L(-1) (all subjects) and increased to 140 and 101 nmol L(-1) in the DD and DP groups, respectively. No significant differences were found between the three groups regarding change in measures of glucose metabolism or serum lipids. In the DP group, there was a slight but significant increase in systolic blood pressure compared with the placebo group. CONCLUSIONS: Our results do not support a positive effect of vitamin D on glucose tolerance, blood pressure or serum lipids. Further studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/20141565/No_improvement_in_cardiovascular_risk_factors_in_overweight_and_obese_subjects_after_supplementation_with_vitamin_D3_for_1_year_ L2 - https://doi.org/10.1111/j.1365-2796.2009.02181.x DB - PRIME DP - Unbound Medicine ER -