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Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.
Mol Vis. 2010 Feb 06; 16:167-77.MV

Abstract

PURPOSE

To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma.

METHODS

We performed meta-analysis and ethnicity-based subgroup analyses according to published studies. Allele and genotype frequencies of SNPs rs1048661, rs2165241, and rs3825942 were extracted for analysis in Reviewer Manager: (1) comparison of the allelic distributions between XFS and XFG, (2) allelic association of LOXL1 SNPs with XFS/XFG, (3) associations in homozygote, heterozygote, and dominant and recessive models, and (4) allelic association with primary open angle glaucoma (POAG).

RESULTS

In total 24 reported articles were retrieved, including Caucasian, African, Japanese, Indian, and Chinese populations. There was no significant difference in the distributions of rs1048661, rs2165241, and rs3825942 between XFS and XFG. The G allele of rs3825942 was the common at-risk allele for XFS/XFG in all populations with a total odds ratio (OR) of 10.89. The total homozygote OR of rs3825942 was 9.06 for XFS/XFG combined, but the total heterozygote OR was not significant. We also found that in the recessive model, the total OR was 14.70. There was no association of the three SNPs with POAG.

CONCLUSIONS

The association of rs3825942, but not rs2165241 or rs1048661, with XFS/XFG is consistent in different ethnic populations in the recessive model. LOXL1 is not associated with POAG in all study populations.

Authors+Show Affiliations

Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China. drchenhaoyu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20142848

Citation

Chen, Haoyu, et al. "Ethnicity-based Subgroup Meta-analysis of the Association of LOXL1 Polymorphisms With Glaucoma." Molecular Vision, vol. 16, 2010, pp. 167-77.
Chen H, Chen LJ, Zhang M, et al. Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma. Mol Vis. 2010;16:167-77.
Chen, H., Chen, L. J., Zhang, M., Gong, W., Tam, P. O., Lam, D. S., & Pang, C. P. (2010). Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma. Molecular Vision, 16, 167-77.
Chen H, et al. Ethnicity-based Subgroup Meta-analysis of the Association of LOXL1 Polymorphisms With Glaucoma. Mol Vis. 2010 Feb 6;16:167-77. PubMed PMID: 20142848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma. AU - Chen,Haoyu, AU - Chen,Li Jia, AU - Zhang,Mingzhi, AU - Gong,Weifeng, AU - Tam,Pancy Oi Sin, AU - Lam,Dennis Shun Chiu, AU - Pang,Chi Pui, Y1 - 2010/02/06/ PY - 2009/12/11/received PY - 2010/02/02/accepted PY - 2010/2/10/entrez PY - 2010/2/10/pubmed PY - 2010/3/11/medline SP - 167 EP - 77 JF - Molecular vision JO - Mol. Vis. VL - 16 N2 - PURPOSE: To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma. METHODS: We performed meta-analysis and ethnicity-based subgroup analyses according to published studies. Allele and genotype frequencies of SNPs rs1048661, rs2165241, and rs3825942 were extracted for analysis in Reviewer Manager: (1) comparison of the allelic distributions between XFS and XFG, (2) allelic association of LOXL1 SNPs with XFS/XFG, (3) associations in homozygote, heterozygote, and dominant and recessive models, and (4) allelic association with primary open angle glaucoma (POAG). RESULTS: In total 24 reported articles were retrieved, including Caucasian, African, Japanese, Indian, and Chinese populations. There was no significant difference in the distributions of rs1048661, rs2165241, and rs3825942 between XFS and XFG. The G allele of rs3825942 was the common at-risk allele for XFS/XFG in all populations with a total odds ratio (OR) of 10.89. The total homozygote OR of rs3825942 was 9.06 for XFS/XFG combined, but the total heterozygote OR was not significant. We also found that in the recessive model, the total OR was 14.70. There was no association of the three SNPs with POAG. CONCLUSIONS: The association of rs3825942, but not rs2165241 or rs1048661, with XFS/XFG is consistent in different ethnic populations in the recessive model. LOXL1 is not associated with POAG in all study populations. SN - 1090-0535 UR - https://www.unboundmedicine.com/medline/citation/20142848/Ethnicity_based_subgroup_meta_analysis_of_the_association_of_LOXL1_polymorphisms_with_glaucoma_ L2 - http://www.molvis.org/molvis/v16/a21/ DB - PRIME DP - Unbound Medicine ER -