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The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease.
Arch Immunol Ther Exp (Warsz). 2010 Apr; 58(2):81-90.AI

Abstract

Thymic stromal lymphopoietin (TSLP) primes dendritic cells to promote a Th2 inflammatory response. Its action is mediated by a heterodimeric receptor which consists of the interleukin-7 receptor alpha chain and the TSLP receptor chain (TSLPR). TSLPR resembles the common gamma chain subunit utilized by many type 1 cytokine receptors. Normal epithelial cells, keratinocytes, and stromal cells constitutively express TSLP. Dendritic cells that are activated by TSLP promote the development of CD4(+) T cells into pro-inflammatory Th2 cells. TSLP thus plays a potentially important role in the pathogenesis of allergic inflammation in asthma and atopic dermatitis. TSLP also has direct effects on other types of cells in the bronchial mucosa. It is over-expressed in the bronchial mucosa in chronic obstructive pulmonary disease (COPD), which is traditionally described as a Th1-related disease, as well as severe asthma, which is traditionally described as a Th2-related disease. In this review we will discuss TSLP expression, function, and available and potential mechanisms in both allergic inflammation and COPD.

Authors+Show Affiliations

Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20143171

Citation

Fang, Cailong, et al. "The Role of Thymic Stromal Lymphopoietin in Allergic Inflammation and Chronic Obstructive Pulmonary Disease." Archivum Immunologiae Et Therapiae Experimentalis, vol. 58, no. 2, 2010, pp. 81-90.
Fang C, Siew LQ, Corrigan CJ, et al. The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease. Arch Immunol Ther Exp (Warsz). 2010;58(2):81-90.
Fang, C., Siew, L. Q., Corrigan, C. J., & Ying, S. (2010). The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease. Archivum Immunologiae Et Therapiae Experimentalis, 58(2), 81-90. https://doi.org/10.1007/s00005-010-0064-3
Fang C, et al. The Role of Thymic Stromal Lymphopoietin in Allergic Inflammation and Chronic Obstructive Pulmonary Disease. Arch Immunol Ther Exp (Warsz). 2010;58(2):81-90. PubMed PMID: 20143171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease. AU - Fang,Cailong, AU - Siew,Leonard Q C, AU - Corrigan,Chris J, AU - Ying,Sun, Y1 - 2010/02/09/ PY - 2009/05/15/received PY - 2009/08/06/accepted PY - 2010/2/10/entrez PY - 2010/2/10/pubmed PY - 2010/5/29/medline SP - 81 EP - 90 JF - Archivum immunologiae et therapiae experimentalis JO - Arch. Immunol. Ther. Exp. (Warsz.) VL - 58 IS - 2 N2 - Thymic stromal lymphopoietin (TSLP) primes dendritic cells to promote a Th2 inflammatory response. Its action is mediated by a heterodimeric receptor which consists of the interleukin-7 receptor alpha chain and the TSLP receptor chain (TSLPR). TSLPR resembles the common gamma chain subunit utilized by many type 1 cytokine receptors. Normal epithelial cells, keratinocytes, and stromal cells constitutively express TSLP. Dendritic cells that are activated by TSLP promote the development of CD4(+) T cells into pro-inflammatory Th2 cells. TSLP thus plays a potentially important role in the pathogenesis of allergic inflammation in asthma and atopic dermatitis. TSLP also has direct effects on other types of cells in the bronchial mucosa. It is over-expressed in the bronchial mucosa in chronic obstructive pulmonary disease (COPD), which is traditionally described as a Th1-related disease, as well as severe asthma, which is traditionally described as a Th2-related disease. In this review we will discuss TSLP expression, function, and available and potential mechanisms in both allergic inflammation and COPD. SN - 1661-4917 UR - https://www.unboundmedicine.com/medline/citation/20143171/The_role_of_thymic_stromal_lymphopoietin_in_allergic_inflammation_and_chronic_obstructive_pulmonary_disease_ L2 - https://dx.doi.org/10.1007/s00005-010-0064-3 DB - PRIME DP - Unbound Medicine ER -