TY - JOUR T1 - Direct asymmetric Michael addition of thioether-based aryl sulfanyl-propan-2-one to nitroalkenes catalyzed by a chiral amine-thiourea bifunctional organocatalyst. AU - Jiang,Xianxing, AU - Zhang,Bangzhi, AU - Zhang,Yifu, AU - Lin,Li, AU - Yan,Wenjin, AU - Wang,Rui, PY - 2010/2/10/entrez PY - 2010/2/10/pubmed PY - 2010/8/27/medline SP - 625 EP - 34 JF - Chirality JO - Chirality VL - 22 IS - 7 N2 - Although the organocatalytic direct asymmetric Michael reactions of carbonyl compounds to nitroalkenes have been investigated intensely, the Michael reaction of the thioether-based donors remains a rather undeveloped field. This work concerns the asymmetric Michael addition of aryl sulfanyl-propan-2-one to nitroalkenes with benzoic acid as an additive, and chiral amine-thiourea as a bifunctional organocatalyst. The reactions provided the highly functionalized chiral adducts with excellent enantioselectivities (up to 96% ee) and good yields. Moreover, the further transformed products exhibited excellent diastereoselectivity. SN - 1520-636X UR - https://www.unboundmedicine.com/medline/citation/20143410/Direct_asymmetric_Michael_addition_of_thioether_based_aryl_sulfanyl_propan_2_one_to_nitroalkenes_catalyzed_by_a_chiral_amine_thiourea_bifunctional_organocatalyst_ L2 - https://doi.org/10.1002/chir.20689 DB - PRIME DP - Unbound Medicine ER -