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[The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus].
Klin Med (Mosk). 2009; 87(11):17-24.KM

Abstract

The aim of this clinico-epidemiological study was to elucidate the role of postprandial hyperglycemia (PH) and high glucose level 2 hours after glucose load in the development of cardiovascular disorders (CDD) in patients with type 2 diabetes mellitus and in the general population. Medical interventions to reduce PH decrease the risk of CDD. Pathophysiological studies show the involvement of oxidative stress in pathogenesis of CDD in cases with PH. Acute hyperglycemia increases heart rate and arterial pressure, disturbs myocardial perfusion and contractility, causes endothelial dysfuncton and atherosclerosis. The following preparations are recommended to subjects with DM2 and PH: alpha-glucosidase inhibitors, glynides, ultrashort-acting insulin analogs, dipeptidylpeptidase-4 inhibitors, exenatide (incretin mimetic).

Authors

Shvarts V
No affiliation info available

MeSH

Blood GlucoseCardiovascular DiseasesDiabetes Mellitus, Type 2Endothelium, VascularHumansHyperglycemiaOxidative StressPostprandial Period

Pub Type(s)

English Abstract
Journal Article
Review

Language

rus

PubMed ID

20143560

Citation

Shvarts, V. "[The Role of Postprandial Hyperglycemia in the Development of Cardiovascular Diseases in Type 2 Diabetes Mellitus]." Klinicheskaia Meditsina, vol. 87, no. 11, 2009, pp. 17-24.
Shvarts V. [The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus]. Klin Med (Mosk). 2009;87(11):17-24.
Shvarts, V. (2009). [The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus]. Klinicheskaia Meditsina, 87(11), 17-24.
Shvarts V. [The Role of Postprandial Hyperglycemia in the Development of Cardiovascular Diseases in Type 2 Diabetes Mellitus]. Klin Med (Mosk). 2009;87(11):17-24. PubMed PMID: 20143560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus]. A1 - Shvarts,V, PY - 2010/2/11/entrez PY - 2010/2/11/pubmed PY - 2010/3/24/medline SP - 17 EP - 24 JF - Klinicheskaia meditsina JO - Klin Med (Mosk) VL - 87 IS - 11 N2 - The aim of this clinico-epidemiological study was to elucidate the role of postprandial hyperglycemia (PH) and high glucose level 2 hours after glucose load in the development of cardiovascular disorders (CDD) in patients with type 2 diabetes mellitus and in the general population. Medical interventions to reduce PH decrease the risk of CDD. Pathophysiological studies show the involvement of oxidative stress in pathogenesis of CDD in cases with PH. Acute hyperglycemia increases heart rate and arterial pressure, disturbs myocardial perfusion and contractility, causes endothelial dysfuncton and atherosclerosis. The following preparations are recommended to subjects with DM2 and PH: alpha-glucosidase inhibitors, glynides, ultrashort-acting insulin analogs, dipeptidylpeptidase-4 inhibitors, exenatide (incretin mimetic). SN - 0023-2149 UR - https://www.unboundmedicine.com/medline/citation/20143560/[The_role_of_postprandial_hyperglycemia_in_the_development_of_cardiovascular_diseases_in_type_2_diabetes_mellitus]_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -