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Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma.
Ann Allergy Asthma Immunol. 2010 Jan; 104(1):36-41.AA

Abstract

BACKGROUND

Airway hyperresponsiveness, which is a characteristic feature of asthma, is usually measured by means of bronchial challenge with direct or indirect stimuli. Vascular endothelial growth factor (VEGF) increases vascular permeability and angiogenesis, leads to mucosal edema, narrows the airway diameter, and reduces airway flow.

OBJECTIVE

To examine the relationships between serum VEGF level and airway responsiveness to methacholine and adenosine monophosphate (AMP) in children with asthma.

METHODS

Peripheral blood eosinophil counts, serum eosinophil cationic protein (ECP) concentrations, and serum VEGF concentrations were measured in 31 asthmatic children and 26 control subjects. Methacholine and AMP bronchial challenges were performed on children with asthma.

RESULTS

Children with asthma had a significantly higher mean (SD) level of VEGF than controls (361.2 [212.0] vs 102.7 [50.0] pg/mL; P < .001). Blood eosinophil counts and serum ECP levels significantly correlated inversely with AMP provocation concentration that caused a decrease in forced expiratory volume in 1 second of 20% (PC20) (r = -0.474, P =.01; r = -0.442, P =.03, respectively), but not with methacholine PC20 (r = -0.228, P = .26; r = -0.338, P =.10, respectively). Serum VEGF levels significantly correlated with airway responsiveness to AMP (r = -0.462; P = .009) but not to methacholine (r = -0.243; P = .19).

CONCLUSIONS

Serum VEGF levels were increased in children with asthma and were related to airway responsiveness to AMP but not to methacholine. Increased VEGF levels in asthmatic children may result in increased airway responsiveness by mechanisms related to airway inflammation or increased permeability of airway vasculature.

Authors+Show Affiliations

Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20143643

Citation

Yoo, Young, et al. "Relationships of Methacholine and Adenosine Monophosphate Responsiveness With Serum Vascular Endothelial Growth Factor in Children With Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 104, no. 1, 2010, pp. 36-41.
Yoo Y, Choi IS, Byeon JH, et al. Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma. Ann Allergy Asthma Immunol. 2010;104(1):36-41.
Yoo, Y., Choi, I. S., Byeon, J. H., Lee, S. M., La, K. S., Choi, B. M., Park, S. H., & Choung, J. T. (2010). Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 104(1), 36-41. https://doi.org/10.1016/j.anai.2009.11.012
Yoo Y, et al. Relationships of Methacholine and Adenosine Monophosphate Responsiveness With Serum Vascular Endothelial Growth Factor in Children With Asthma. Ann Allergy Asthma Immunol. 2010;104(1):36-41. PubMed PMID: 20143643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma. AU - Yoo,Young, AU - Choi,Ic Sun, AU - Byeon,Jung Hye, AU - Lee,Seung Min, AU - La,Kyong Suk, AU - Choi,Byung Min, AU - Park,Sang Hee, AU - Choung,Ji Tae, PY - 2010/2/11/entrez PY - 2010/2/11/pubmed PY - 2010/4/8/medline SP - 36 EP - 41 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 104 IS - 1 N2 - BACKGROUND: Airway hyperresponsiveness, which is a characteristic feature of asthma, is usually measured by means of bronchial challenge with direct or indirect stimuli. Vascular endothelial growth factor (VEGF) increases vascular permeability and angiogenesis, leads to mucosal edema, narrows the airway diameter, and reduces airway flow. OBJECTIVE: To examine the relationships between serum VEGF level and airway responsiveness to methacholine and adenosine monophosphate (AMP) in children with asthma. METHODS: Peripheral blood eosinophil counts, serum eosinophil cationic protein (ECP) concentrations, and serum VEGF concentrations were measured in 31 asthmatic children and 26 control subjects. Methacholine and AMP bronchial challenges were performed on children with asthma. RESULTS: Children with asthma had a significantly higher mean (SD) level of VEGF than controls (361.2 [212.0] vs 102.7 [50.0] pg/mL; P < .001). Blood eosinophil counts and serum ECP levels significantly correlated inversely with AMP provocation concentration that caused a decrease in forced expiratory volume in 1 second of 20% (PC20) (r = -0.474, P =.01; r = -0.442, P =.03, respectively), but not with methacholine PC20 (r = -0.228, P = .26; r = -0.338, P =.10, respectively). Serum VEGF levels significantly correlated with airway responsiveness to AMP (r = -0.462; P = .009) but not to methacholine (r = -0.243; P = .19). CONCLUSIONS: Serum VEGF levels were increased in children with asthma and were related to airway responsiveness to AMP but not to methacholine. Increased VEGF levels in asthmatic children may result in increased airway responsiveness by mechanisms related to airway inflammation or increased permeability of airway vasculature. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/20143643/Relationships_of_methacholine_and_adenosine_monophosphate_responsiveness_with_serum_vascular_endothelial_growth_factor_in_children_with_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(09)00013-1 DB - PRIME DP - Unbound Medicine ER -