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Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women.
J Obstet Gynaecol Res. 2009 Dec; 35(6):1091-5.JO

Abstract

AIM

Menopause is associated with adverse metabolic changes, especially in plasma lipoprotein and cholesterol levels. Estrogens have beneficial effects on lipid metabolism. Phytoestrogens are plant substances that are structurally and functionally similar to 17beta-estradiol and are capable of producing estrogenic effects. The goal of the present study was to estimate the effects of red clover-derived isoflavones on serum lipid levels in postmenopausal women.

METHODS

The study comprised 40 healthy postmenopausal women with an average age of 56 years. The women were divided into two groups: 22 were allocated to a red clover-derived isoflavone medication group, and 18 were allocated to a non-medication group. Total blood cholesterol, cholesterol fractions and triglycerides in the women of both groups were investigated before treatment and at 4-month intervals over the following 12 months.

RESULTS

Both total serum cholesterol and low-density lipoprotein (LDL) cholesterol levels, as well as triglyceride levels, were decreased significantly in the group receiving phytoestrogens. However, high-density lipoprotein (HDL) cholesterol showed a significant increase.

CONCLUSION

Red clover phytoestrogen supplementation in postmenopausal women had favorable metabolic effects on serum lipids. Furthermore, red clover phytoestrogens have no side-effects and can be considered safe.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, School of Medicine, University of Belgrade, Belgrade, Serbia. terzicmilan@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20144173

Citation

Terzic, Milan M., et al. "Influence of Red Clover-derived Isoflavones On Serum Lipid Profile in Postmenopausal Women." The Journal of Obstetrics and Gynaecology Research, vol. 35, no. 6, 2009, pp. 1091-5.
Terzic MM, Dotlic J, Maricic S, et al. Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women. J Obstet Gynaecol Res. 2009;35(6):1091-5.
Terzic, M. M., Dotlic, J., Maricic, S., Mihailovic, T., & Tosic-Race, B. (2009). Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women. The Journal of Obstetrics and Gynaecology Research, 35(6), 1091-5. https://doi.org/10.1111/j.1447-0756.2009.001059.x
Terzic MM, et al. Influence of Red Clover-derived Isoflavones On Serum Lipid Profile in Postmenopausal Women. J Obstet Gynaecol Res. 2009;35(6):1091-5. PubMed PMID: 20144173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women. AU - Terzic,Milan M, AU - Dotlic,Jelena, AU - Maricic,Sanja, AU - Mihailovic,Tihomir, AU - Tosic-Race,Bratislava, PY - 2010/2/11/entrez PY - 2010/2/11/pubmed PY - 2010/5/26/medline SP - 1091 EP - 5 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 35 IS - 6 N2 - AIM: Menopause is associated with adverse metabolic changes, especially in plasma lipoprotein and cholesterol levels. Estrogens have beneficial effects on lipid metabolism. Phytoestrogens are plant substances that are structurally and functionally similar to 17beta-estradiol and are capable of producing estrogenic effects. The goal of the present study was to estimate the effects of red clover-derived isoflavones on serum lipid levels in postmenopausal women. METHODS: The study comprised 40 healthy postmenopausal women with an average age of 56 years. The women were divided into two groups: 22 were allocated to a red clover-derived isoflavone medication group, and 18 were allocated to a non-medication group. Total blood cholesterol, cholesterol fractions and triglycerides in the women of both groups were investigated before treatment and at 4-month intervals over the following 12 months. RESULTS: Both total serum cholesterol and low-density lipoprotein (LDL) cholesterol levels, as well as triglyceride levels, were decreased significantly in the group receiving phytoestrogens. However, high-density lipoprotein (HDL) cholesterol showed a significant increase. CONCLUSION: Red clover phytoestrogen supplementation in postmenopausal women had favorable metabolic effects on serum lipids. Furthermore, red clover phytoestrogens have no side-effects and can be considered safe. SN - 1447-0756 UR - https://www.unboundmedicine.com/medline/citation/20144173/Influence_of_red_clover_derived_isoflavones_on_serum_lipid_profile_in_postmenopausal_women_ L2 - https://doi.org/10.1111/j.1447-0756.2009.001059.x DB - PRIME DP - Unbound Medicine ER -