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Association of apolipoproteins e4 and c1 with onset age and memory: a study of sporadic Alzheimer disease in Taiwan.
J Geriatr Psychiatry Neurol 2010; 23(1):42-8JG

Abstract

OBJECTIVE

To identify clinical manifestations and neuropsychological effects of Alzheimer disease (AD) in apolipoprotein (ApoE) e4 carriers and to investigate the relationships between ApoE HhaI polymorphism and apolipoprotein C1 (APOC1) HpaI polymorphism in Taiwanese patients with AD.

PARTICIPANTS AND METHODS

A total of 127 patients with AD and 191 elderly individuals were screened for ApoE and APOC1 polymorphism. All patients underwent neuropsychological testing, including a Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and/or the Visual Association Memory Test (VAMT) with Cognitive Abilities Screening Instrument.

RESULTS

The frequencies of the e4 and A alleles were significantly higher in the AD group. In the patients with AD, the e4 and A allele effects on those with an age-of-onset of 60 to 79 years were stronger than those with an age-of-onset of 80 years or higher. Visual Association Memory Test performance was significantly worse in e4-allele carriers but not in A-allele carriers, in the early AD, particularly in those affected with AD for less than 2 years. Although there was no statistically significant difference in genotypic frequency between patients and controls, the 2 genes were linked. In addition, the presence of the AA genotype concomitant with the e4 allele may be better associated with AD diagnosis than either factor alone.

CONCLUSION

We conclude that the e4 allele affects neuropsychological performance and illness morbidity. Concomitantly, ApoE e4 and APOC1 A alleles have a better association with AD than ApoE e4 alone. In addition, APOC1 may partially contribute to the pathogenesis of AD, but the nature of its relationship with e4 requires further investigation.

Authors+Show Affiliations

Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20145290

Citation

Chuang, Wen-Li, et al. "Association of Apolipoproteins E4 and C1 With Onset Age and Memory: a Study of Sporadic Alzheimer Disease in Taiwan." Journal of Geriatric Psychiatry and Neurology, vol. 23, no. 1, 2010, pp. 42-8.
Chuang WL, Hsieh YC, Wang CY, et al. Association of apolipoproteins e4 and c1 with onset age and memory: a study of sporadic Alzheimer disease in Taiwan. J Geriatr Psychiatry Neurol. 2010;23(1):42-8.
Chuang, W. L., Hsieh, Y. C., Wang, C. Y., Kuo, H. C., & Huang, C. C. (2010). Association of apolipoproteins e4 and c1 with onset age and memory: a study of sporadic Alzheimer disease in Taiwan. Journal of Geriatric Psychiatry and Neurology, 23(1), pp. 42-8. doi:10.1177/0891988709351804.
Chuang WL, et al. Association of Apolipoproteins E4 and C1 With Onset Age and Memory: a Study of Sporadic Alzheimer Disease in Taiwan. J Geriatr Psychiatry Neurol. 2010;23(1):42-8. PubMed PMID: 20145290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of apolipoproteins e4 and c1 with onset age and memory: a study of sporadic Alzheimer disease in Taiwan. AU - Chuang,Wen-Li, AU - Hsieh,Yu-Chen, AU - Wang,Chun-Yi, AU - Kuo,Hung-Chou, AU - Huang,Chin-Chang, PY - 2010/2/11/entrez PY - 2010/2/11/pubmed PY - 2010/5/12/medline SP - 42 EP - 8 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 23 IS - 1 N2 - OBJECTIVE: To identify clinical manifestations and neuropsychological effects of Alzheimer disease (AD) in apolipoprotein (ApoE) e4 carriers and to investigate the relationships between ApoE HhaI polymorphism and apolipoprotein C1 (APOC1) HpaI polymorphism in Taiwanese patients with AD. PARTICIPANTS AND METHODS: A total of 127 patients with AD and 191 elderly individuals were screened for ApoE and APOC1 polymorphism. All patients underwent neuropsychological testing, including a Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and/or the Visual Association Memory Test (VAMT) with Cognitive Abilities Screening Instrument. RESULTS: The frequencies of the e4 and A alleles were significantly higher in the AD group. In the patients with AD, the e4 and A allele effects on those with an age-of-onset of 60 to 79 years were stronger than those with an age-of-onset of 80 years or higher. Visual Association Memory Test performance was significantly worse in e4-allele carriers but not in A-allele carriers, in the early AD, particularly in those affected with AD for less than 2 years. Although there was no statistically significant difference in genotypic frequency between patients and controls, the 2 genes were linked. In addition, the presence of the AA genotype concomitant with the e4 allele may be better associated with AD diagnosis than either factor alone. CONCLUSION: We conclude that the e4 allele affects neuropsychological performance and illness morbidity. Concomitantly, ApoE e4 and APOC1 A alleles have a better association with AD than ApoE e4 alone. In addition, APOC1 may partially contribute to the pathogenesis of AD, but the nature of its relationship with e4 requires further investigation. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/20145290/Association_of_apolipoproteins_e4_and_c1_with_onset_age_and_memory:_a_study_of_sporadic_Alzheimer_disease_in_Taiwan_ L2 - http://journals.sagepub.com/doi/full/10.1177/0891988709351804?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -