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Urinary excretion of oxalate by patients with renal hypercalciuric stone disease. Effect of chronic treatment with hydrochlorothiazide.
Urology 1991; 37(4):327-30U

Abstract

Hydrochlorothiazide is employed to reduce calcium excretion in patients with urinary stone disease secondary to renal leak hypercalciuria. Because the drug also has been reported to be a competitive inhibitor of oxalate excretion by the renal tubules, we sought to determine whether chronic use indeed affected the amount of oxalate excreted. Patients taking hydrochlorothiazide 50 mg daily did not have a statistically significant reduction in twenty-four-hour urinary oxalate on their customary diets (pretreatment 37 +/- 3 mg/day [mean +/- S.E.M.; N = 22]; at one year 36 +/- 3 mg/day [N = 22]; at two years 37 +/- 3 mg/day [N = 16]). In 12 patients who voluntarily collected twelve-hour urine specimens after dinner on the third day of a low-oxalate diet and again the next day after a 1 g oxalate load, hydrochlorothiazide had no significant effect on oxalate excretion (19 +/- 2.3 mmol oxalate/mol creatinine on hydrochlorothiazide versus 20.6 +/- 2.6 mmol off the drug after low oxalate meal; 50 +/- 7.8 mmol/mol creatinine on hydrochlorothiazide versus 56.2 +/- 7.5 mmol off the drug after an oxalate load). As expected, there was a significant reduction in urinary calcium excretion and thus of calcium oxalate urinary saturation during hydrochlorothiazide administration. Hydrochlorothiazide by itself is not sufficient to reduce oxalate excretion in patients with renal leak hypercalciuria.

Authors+Show Affiliations

Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2014597

Citation

Urivetzky, M, et al. "Urinary Excretion of Oxalate By Patients With Renal Hypercalciuric Stone Disease. Effect of Chronic Treatment With Hydrochlorothiazide." Urology, vol. 37, no. 4, 1991, pp. 327-30.
Urivetzky M, Braverman S, Motola JA, et al. Urinary excretion of oxalate by patients with renal hypercalciuric stone disease. Effect of chronic treatment with hydrochlorothiazide. Urology. 1991;37(4):327-30.
Urivetzky, M., Braverman, S., Motola, J. A., & Smith, A. D. (1991). Urinary excretion of oxalate by patients with renal hypercalciuric stone disease. Effect of chronic treatment with hydrochlorothiazide. Urology, 37(4), pp. 327-30.
Urivetzky M, et al. Urinary Excretion of Oxalate By Patients With Renal Hypercalciuric Stone Disease. Effect of Chronic Treatment With Hydrochlorothiazide. Urology. 1991;37(4):327-30. PubMed PMID: 2014597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of oxalate by patients with renal hypercalciuric stone disease. Effect of chronic treatment with hydrochlorothiazide. AU - Urivetzky,M, AU - Braverman,S, AU - Motola,J A, AU - Smith,A D, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 327 EP - 30 JF - Urology JO - Urology VL - 37 IS - 4 N2 - Hydrochlorothiazide is employed to reduce calcium excretion in patients with urinary stone disease secondary to renal leak hypercalciuria. Because the drug also has been reported to be a competitive inhibitor of oxalate excretion by the renal tubules, we sought to determine whether chronic use indeed affected the amount of oxalate excreted. Patients taking hydrochlorothiazide 50 mg daily did not have a statistically significant reduction in twenty-four-hour urinary oxalate on their customary diets (pretreatment 37 +/- 3 mg/day [mean +/- S.E.M.; N = 22]; at one year 36 +/- 3 mg/day [N = 22]; at two years 37 +/- 3 mg/day [N = 16]). In 12 patients who voluntarily collected twelve-hour urine specimens after dinner on the third day of a low-oxalate diet and again the next day after a 1 g oxalate load, hydrochlorothiazide had no significant effect on oxalate excretion (19 +/- 2.3 mmol oxalate/mol creatinine on hydrochlorothiazide versus 20.6 +/- 2.6 mmol off the drug after low oxalate meal; 50 +/- 7.8 mmol/mol creatinine on hydrochlorothiazide versus 56.2 +/- 7.5 mmol off the drug after an oxalate load). As expected, there was a significant reduction in urinary calcium excretion and thus of calcium oxalate urinary saturation during hydrochlorothiazide administration. Hydrochlorothiazide by itself is not sufficient to reduce oxalate excretion in patients with renal leak hypercalciuria. SN - 0090-4295 UR - https://www.unboundmedicine.com/medline/citation/2014597/Urinary_excretion_of_oxalate_by_patients_with_renal_hypercalciuric_stone_disease__Effect_of_chronic_treatment_with_hydrochlorothiazide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-4295(91)80258-9 DB - PRIME DP - Unbound Medicine ER -