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Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats.
J Biochem Mol Toxicol. 2010 Mar-Apr; 24(2):95-101.JB

Abstract

Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diabetic rats on carbohydrate metabolism was investigated, and its antihyperglycemic effect was shown previously (Chandramohan et al., Eur J Pharmacol 2008;590:437-443). In this study we investigated the effect of 3-HMX on plasma and tissue lipid profiles in streptozotocin-induced diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. The normal and diabetic rats were treated with 3-HMX (40 mg/kg BW/day) for 45 days. The levels of total cholesterol, triglycerides, free fatty acids, and phospholipids were assayed in the plasma besides lipoprotein-cholesterol (high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C)) and tissues (liver, kidney, heart, and brain). Total cholesterol, triglyceride, free fatty acid, and phospholipid (LDL-C and VLDL-C in plasma only) levels increased in plasma and tissues significantly, whereas plasma HDL-C significantly decreased in diabetic rats. Treatment with 3-HMX or glibenclamide reversed the above-mentioned changes and improved toward normalcy. Histological study of liver also confirmed the biochemical findings. Thus administration of 3-HMX is able to reduce hyperglycemia and hyperlipidemia related to the risk of diabetes mellitus.

Authors+Show Affiliations

Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, Riyadh-11433, Kingdom of Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20146230

Citation

Chandramohan, Govindasamy, et al. "Antihyperlipidemic Activity of 3-hydroxymethyl Xylitol, a Novel Antidiabetic Compound Isolated From Casearia Esculenta (Roxb.) Root, in Streptozotocin-diabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 24, no. 2, 2010, pp. 95-101.
Chandramohan G, Al-Numair KS, Sridevi M, et al. Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats. J Biochem Mol Toxicol. 2010;24(2):95-101.
Chandramohan, G., Al-Numair, K. S., Sridevi, M., & Pugalendi, K. V. (2010). Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats. Journal of Biochemical and Molecular Toxicology, 24(2), 95-101. https://doi.org/10.1002/jbt.20317
Chandramohan G, et al. Antihyperlipidemic Activity of 3-hydroxymethyl Xylitol, a Novel Antidiabetic Compound Isolated From Casearia Esculenta (Roxb.) Root, in Streptozotocin-diabetic Rats. J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):95-101. PubMed PMID: 20146230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperlipidemic activity of 3-hydroxymethyl xylitol, a novel antidiabetic compound isolated from Casearia esculenta (Roxb.) root, in streptozotocin-diabetic rats. AU - Chandramohan,Govindasamy, AU - Al-Numair,Khalid S, AU - Sridevi,Muruhan, AU - Pugalendi,Kodukkur Viswanathan, PY - 2010/2/11/entrez PY - 2010/2/11/pubmed PY - 2010/9/21/medline SP - 95 EP - 101 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 24 IS - 2 N2 - Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diabetic rats on carbohydrate metabolism was investigated, and its antihyperglycemic effect was shown previously (Chandramohan et al., Eur J Pharmacol 2008;590:437-443). In this study we investigated the effect of 3-HMX on plasma and tissue lipid profiles in streptozotocin-induced diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. The normal and diabetic rats were treated with 3-HMX (40 mg/kg BW/day) for 45 days. The levels of total cholesterol, triglycerides, free fatty acids, and phospholipids were assayed in the plasma besides lipoprotein-cholesterol (high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C)) and tissues (liver, kidney, heart, and brain). Total cholesterol, triglyceride, free fatty acid, and phospholipid (LDL-C and VLDL-C in plasma only) levels increased in plasma and tissues significantly, whereas plasma HDL-C significantly decreased in diabetic rats. Treatment with 3-HMX or glibenclamide reversed the above-mentioned changes and improved toward normalcy. Histological study of liver also confirmed the biochemical findings. Thus administration of 3-HMX is able to reduce hyperglycemia and hyperlipidemia related to the risk of diabetes mellitus. SN - 1099-0461 UR - https://www.unboundmedicine.com/medline/citation/20146230/Antihyperlipidemic_activity_of_3_hydroxymethyl_xylitol_a_novel_antidiabetic_compound_isolated_from_Casearia_esculenta__Roxb___root_in_streptozotocin_diabetic_rats_ L2 - https://doi.org/10.1002/jbt.20317 DB - PRIME DP - Unbound Medicine ER -