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Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome.
J Perinat Med 2010; 38(2):141-6JP

Abstract

AIMS

To investigate metabolic characteristics and perinatal outcomes of gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS).

METHODS

We evaluated 34 GDM in women with PCOS and 70 GDM in women without PCOS in this prospective study. All GDM women were treated with medical nutrition therapy (MNT). Pre-pregnancy clinical data, fasting glucose, fasting insulin (FINS), blood lipid, homeostasis model assessment index of insulin resistance (HOMA-IR) and perinatal outcomes were investigated.

RESULTS

GDM in women with PCOS had higher pre-pregnancy body mass index (BMI), higher incidence of overweight than in the non-PCOS group (each P<0.001). Incidence of history of infertility was also significantly higher in the PCOS group than in the non-PCOS group (20.6% vs. 2.9%, P<0.01). A higher incidence of early pregnancy loss (EPL) was found in the PCOS group than in the non-PCOS group (20.6% vs. 7.1%, P<0.05). Significantly higher in vitro fertilization and embryo transfer (IVF-ET) rate and insulin administration was also observed in the PCOS group than in the controls. No significant difference was found in the prevalence of preeclampsia, premature delivery, macrosomia, fetal death and neonatal congenital anomaly between GDM in women with and without PCOS (all P>0.05). [corrected]

CONCLUSIONS

Compared with the controls, no significant increase in the incidence of adverse perinatal outcomes was detected in GDM in women with PCOS by appropriate management.

Authors+Show Affiliations

Beijing Obstetrics and Gynecology Hospital, Capital Medical [corrected] University, Beijing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20146658

Citation

Li, Guanghui, et al. "Metabolic Parameters and Perinatal Outcomes of Gestational Diabetes Mellitus in Women With Polycystic Ovary Syndrome." Journal of Perinatal Medicine, vol. 38, no. 2, 2010, pp. 141-6.
Li G, Fan L, Zhang L, et al. Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome. J Perinat Med. 2010;38(2):141-6.
Li, G., Fan, L., Zhang, L., Zhang, W., & Huang, X. (2010). Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome. Journal of Perinatal Medicine, 38(2), pp. 141-6. doi:10.1515/JPM.2010.034.
Li G, et al. Metabolic Parameters and Perinatal Outcomes of Gestational Diabetes Mellitus in Women With Polycystic Ovary Syndrome. J Perinat Med. 2010;38(2):141-6. PubMed PMID: 20146658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome. AU - Li,Guanghui, AU - Fan,Ling, AU - Zhang,Li, AU - Zhang,Weiyuan, AU - Huang,Xinghua, PY - 2010/2/12/entrez PY - 2010/2/12/pubmed PY - 2010/6/4/medline SP - 141 EP - 6 JF - Journal of perinatal medicine JO - J Perinat Med VL - 38 IS - 2 N2 - AIMS: To investigate metabolic characteristics and perinatal outcomes of gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS). METHODS: We evaluated 34 GDM in women with PCOS and 70 GDM in women without PCOS in this prospective study. All GDM women were treated with medical nutrition therapy (MNT). Pre-pregnancy clinical data, fasting glucose, fasting insulin (FINS), blood lipid, homeostasis model assessment index of insulin resistance (HOMA-IR) and perinatal outcomes were investigated. RESULTS: GDM in women with PCOS had higher pre-pregnancy body mass index (BMI), higher incidence of overweight than in the non-PCOS group (each P<0.001). Incidence of history of infertility was also significantly higher in the PCOS group than in the non-PCOS group (20.6% vs. 2.9%, P<0.01). A higher incidence of early pregnancy loss (EPL) was found in the PCOS group than in the non-PCOS group (20.6% vs. 7.1%, P<0.05). Significantly higher in vitro fertilization and embryo transfer (IVF-ET) rate and insulin administration was also observed in the PCOS group than in the controls. No significant difference was found in the prevalence of preeclampsia, premature delivery, macrosomia, fetal death and neonatal congenital anomaly between GDM in women with and without PCOS (all P>0.05). [corrected] CONCLUSIONS: Compared with the controls, no significant increase in the incidence of adverse perinatal outcomes was detected in GDM in women with PCOS by appropriate management. SN - 1619-3997 UR - https://www.unboundmedicine.com/medline/citation/20146658/Metabolic_parameters_and_perinatal_outcomes_of_gestational_diabetes_mellitus_in_women_with_polycystic_ovary_syndrome_ L2 - https://www.degruyter.com/doi/10.1515/JPM.2010.034 DB - PRIME DP - Unbound Medicine ER -