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The progression of pathology in Parkinson's disease.
Ann N Y Acad Sci. 2010 Jan; 1184:188-95.AN

Abstract

To identify the progression of pathology over the entire course of Parkinson's disease, we longitudinally followed a clinical cohort to autopsy and identified three clinicopathological phenotypes that progress at different rates. Typical Parkinson's disease has an initial rapid loss of midbrain dopamine neurons with a slow progression of Lewy body infiltration into the brain (over decades). Dementia intervenes late when Lewy bodies invade the neocortex. Older onset patients (> 70 years old) dement earlier and have much shorter disease durations. Paradoxically, they have far more alpha-synuclein-containing Lewy bodies throughout the brain, and many also have additional age-related plaque pathology. In contrast, dementia with Lewy bodies has the shortest disease course, with substantive amounts of Lewy bodies and Alzheimer-type pathologies infiltrating the brain. These data suggest that two age-related factors influence pathological progression in Parkinson's disease--the age at symptom onset and the degree and type of age-related Alzheimer-type pathology.

Authors+Show Affiliations

Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia. g.halliday@powmri.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20146698

Citation

Halliday, Glenda Margaret, and Heather McCann. "The Progression of Pathology in Parkinson's Disease." Annals of the New York Academy of Sciences, vol. 1184, 2010, pp. 188-95.
Halliday GM, McCann H. The progression of pathology in Parkinson's disease. Ann N Y Acad Sci. 2010;1184:188-95.
Halliday, G. M., & McCann, H. (2010). The progression of pathology in Parkinson's disease. Annals of the New York Academy of Sciences, 1184, 188-95. https://doi.org/10.1111/j.1749-6632.2009.05118.x
Halliday GM, McCann H. The Progression of Pathology in Parkinson's Disease. Ann N Y Acad Sci. 2010;1184:188-95. PubMed PMID: 20146698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The progression of pathology in Parkinson's disease. AU - Halliday,Glenda Margaret, AU - McCann,Heather, PY - 2010/2/12/entrez PY - 2010/2/12/pubmed PY - 2010/3/26/medline SP - 188 EP - 95 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1184 N2 - To identify the progression of pathology over the entire course of Parkinson's disease, we longitudinally followed a clinical cohort to autopsy and identified three clinicopathological phenotypes that progress at different rates. Typical Parkinson's disease has an initial rapid loss of midbrain dopamine neurons with a slow progression of Lewy body infiltration into the brain (over decades). Dementia intervenes late when Lewy bodies invade the neocortex. Older onset patients (> 70 years old) dement earlier and have much shorter disease durations. Paradoxically, they have far more alpha-synuclein-containing Lewy bodies throughout the brain, and many also have additional age-related plaque pathology. In contrast, dementia with Lewy bodies has the shortest disease course, with substantive amounts of Lewy bodies and Alzheimer-type pathologies infiltrating the brain. These data suggest that two age-related factors influence pathological progression in Parkinson's disease--the age at symptom onset and the degree and type of age-related Alzheimer-type pathology. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/20146698/The_progression_of_pathology_in_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1749-6632.2009.05118.x DB - PRIME DP - Unbound Medicine ER -