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Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats.
Food Chem Toxicol. 2010 May; 48(5):1178-84.FC

Abstract

Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with berries were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in rats. CRAN was given orally to rats (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) was administered on the seventh day. CRAN protected against DOX-induced increased mortality and ECG changes. It significantly inhibited DOX-provoked glutathione (GSH) depletion and accumulation of oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls in cardiac tissues. The reductions of cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Elevation of cardiac myeloperoxidase (MPO) activity in response to DOX treatment was significantly hampered. Pretreatment of CRAN significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), creatine kinase-MB (CK-MB) as well as troponin I level. CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats. This can be attributed, at least in part, to CRAN's antioxidant activity.

Authors+Show Affiliations

Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20146931

Citation

Elberry, Ahmed A., et al. "Cranberry (Vaccinium Macrocarpon) Protects Against Doxorubicin-induced Cardiotoxicity in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 5, 2010, pp. 1178-84.
Elberry AA, Abdel-Naim AB, Abdel-Sattar EA, et al. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem Toxicol. 2010;48(5):1178-84.
Elberry, A. A., Abdel-Naim, A. B., Abdel-Sattar, E. A., Nagy, A. A., Mosli, H. A., Mohamadin, A. M., & Ashour, O. M. (2010). Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(5), 1178-84. https://doi.org/10.1016/j.fct.2010.02.008
Elberry AA, et al. Cranberry (Vaccinium Macrocarpon) Protects Against Doxorubicin-induced Cardiotoxicity in Rats. Food Chem Toxicol. 2010;48(5):1178-84. PubMed PMID: 20146931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. AU - Elberry,Ahmed A, AU - Abdel-Naim,Ashraf B, AU - Abdel-Sattar,Essam A, AU - Nagy,Ayman A, AU - Mosli,Hisham A, AU - Mohamadin,Ahmed M, AU - Ashour,Osama M, Y1 - 2010/02/08/ PY - 2009/11/08/received PY - 2010/01/21/revised PY - 2010/02/03/accepted PY - 2010/2/12/entrez PY - 2010/2/12/pubmed PY - 2010/7/7/medline SP - 1178 EP - 84 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 48 IS - 5 N2 - Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with berries were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in rats. CRAN was given orally to rats (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) was administered on the seventh day. CRAN protected against DOX-induced increased mortality and ECG changes. It significantly inhibited DOX-provoked glutathione (GSH) depletion and accumulation of oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls in cardiac tissues. The reductions of cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Elevation of cardiac myeloperoxidase (MPO) activity in response to DOX treatment was significantly hampered. Pretreatment of CRAN significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), creatine kinase-MB (CK-MB) as well as troponin I level. CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats. This can be attributed, at least in part, to CRAN's antioxidant activity. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20146931/Cranberry__Vaccinium_macrocarpon__protects_against_doxorubicin_induced_cardiotoxicity_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00093-1 DB - PRIME DP - Unbound Medicine ER -