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Human sex differences in d-amphetamine self-administration.
Addiction. 2010 Apr; 105(4):727-31.A

Abstract

Women and men may respond differently to the effects of stimulants such as amphetamine and cocaine.

AIM

In order to assess potential sex differences in the reinforcing effects of d-amphetamine, a retrospective-analysis was conducted on data collected from three studies that employed similar d-amphetamine self-administration procedures and used identical subject-rated drug-effect measures.

METHODS

Data from 10 women and 15 men were included in the analysis. In all studies, participants sampled placebo, low (8-10 mg) or high (16-20 mg) dose oral d-amphetamine. Following sampling sessions, participants worked for capsules containing one eighth of the previously sampled dose on a modified progressive-ratio schedule of reinforcement. We hypothesized that women and men would be differentially sensitive to the reinforcing effects of d-amphetamine. A two-way mixed-model analysis of variance (sex and dose) and planned comparisons were used in the statistical analyses.

RESULTS

The low dose of d-amphetamine functioned as a reinforcer in women, but not men, whereas the high dose of d-amphetamine functioned as a reinforcer in men, but not women. Men self-administered significantly more capsules under the high dose condition than women.

CONCLUSION

The results of this study suggest that men are more sensitive to the reinforcing effects of a high dose of d-amphetamine than women. Future research is needed that determines prospectively the reinforcing effects of weight-adjusted doses of d-amphetamine in women and men while controlling for menstrual cycle phase.

Authors+Show Affiliations

Department of Psychology, University of Kentucky, Lexington, KY, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20148783

Citation

Vansickel, Andrea R., et al. "Human Sex Differences in D-amphetamine Self-administration." Addiction (Abingdon, England), vol. 105, no. 4, 2010, pp. 727-31.
Vansickel AR, Stoops WW, Rush CR. Human sex differences in d-amphetamine self-administration. Addiction. 2010;105(4):727-31.
Vansickel, A. R., Stoops, W. W., & Rush, C. R. (2010). Human sex differences in d-amphetamine self-administration. Addiction (Abingdon, England), 105(4), 727-31. https://doi.org/10.1111/j.1360-0443.2009.02858.x
Vansickel AR, Stoops WW, Rush CR. Human Sex Differences in D-amphetamine Self-administration. Addiction. 2010;105(4):727-31. PubMed PMID: 20148783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human sex differences in d-amphetamine self-administration. AU - Vansickel,Andrea R, AU - Stoops,William W, AU - Rush,Craig R, Y1 - 2010/02/09/ PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/10/5/medline SP - 727 EP - 31 JF - Addiction (Abingdon, England) JO - Addiction VL - 105 IS - 4 N2 - UNLABELLED: Women and men may respond differently to the effects of stimulants such as amphetamine and cocaine. AIM: In order to assess potential sex differences in the reinforcing effects of d-amphetamine, a retrospective-analysis was conducted on data collected from three studies that employed similar d-amphetamine self-administration procedures and used identical subject-rated drug-effect measures. METHODS: Data from 10 women and 15 men were included in the analysis. In all studies, participants sampled placebo, low (8-10 mg) or high (16-20 mg) dose oral d-amphetamine. Following sampling sessions, participants worked for capsules containing one eighth of the previously sampled dose on a modified progressive-ratio schedule of reinforcement. We hypothesized that women and men would be differentially sensitive to the reinforcing effects of d-amphetamine. A two-way mixed-model analysis of variance (sex and dose) and planned comparisons were used in the statistical analyses. RESULTS: The low dose of d-amphetamine functioned as a reinforcer in women, but not men, whereas the high dose of d-amphetamine functioned as a reinforcer in men, but not women. Men self-administered significantly more capsules under the high dose condition than women. CONCLUSION: The results of this study suggest that men are more sensitive to the reinforcing effects of a high dose of d-amphetamine than women. Future research is needed that determines prospectively the reinforcing effects of weight-adjusted doses of d-amphetamine in women and men while controlling for menstrual cycle phase. SN - 1360-0443 UR - https://www.unboundmedicine.com/medline/citation/20148783/Human_sex_differences_in_d_amphetamine_self_administration_ L2 - https://doi.org/10.1111/j.1360-0443.2009.02858.x DB - PRIME DP - Unbound Medicine ER -