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Dopamine on D2-like receptors "reboosts" dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose.
Neuropharmacology. 2010 Jun; 58(7):1085-96.N

Abstract

BACKGROUND

The analysis of licking microstructure provides measures, such as duration and number of licking bouts, which might reveal the former an evaluation process and the latter an approach response. Dopamine D2-like receptor antagonists reduce the duration of licking bouts and mimic the effect of reducing sucrose concentration, while conflicting results are reported on the effects of dopamine D1-like receptor antagonists. The aim of this study is to examine the roles of dopamine D1-like and D2-like receptors in the activation of reward-associated responses and in reward evaluation, through the study of licking microstructure.

METHODS

The effects of the dopamine D2-like receptor antagonists raclopride (0.025-0.25 mg/kg), the D1-like antagonist SCH 23390 (0.01-0.04 mg/kg) and the antipsychotic drug haloperidol (0.02-0.05 mg/kg), have been examined on the microstructure of licking for a 10% sucrose solution in rats.

RESULTS

The results confirm that dopamine D2-like receptor antagonists reduce the duration of licking bouts and reveal that while SCH 23390 reduced licking exclusively by reducing bout number, raclopride produced on this measure an extinction mimicry effect similar to that observed in instrumental responding for different rewards.

DISCUSSION

These results are consistent with the hypothesis that the level of activation of the responses to the reward-associated cues depends on dopamine D1-like receptor stimulation, and is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process occurring during the consummatory transaction with the reward.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, Via Muroni, 23/A, 07100 Sassari, Italy. dsfpaolo@uniss.it

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20149807

Citation

D'Aquila, Paolo S.. "Dopamine On D2-like Receptors "reboosts" Dopamine D1-like Receptor-mediated Behavioural Activation in Rats Licking for Sucrose." Neuropharmacology, vol. 58, no. 7, 2010, pp. 1085-96.
D'Aquila PS. Dopamine on D2-like receptors "reboosts" dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose. Neuropharmacology. 2010;58(7):1085-96.
D'Aquila, P. S. (2010). Dopamine on D2-like receptors "reboosts" dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose. Neuropharmacology, 58(7), 1085-96. https://doi.org/10.1016/j.neuropharm.2010.01.017
D'Aquila PS. Dopamine On D2-like Receptors "reboosts" Dopamine D1-like Receptor-mediated Behavioural Activation in Rats Licking for Sucrose. Neuropharmacology. 2010;58(7):1085-96. PubMed PMID: 20149807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine on D2-like receptors "reboosts" dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose. A1 - D'Aquila,Paolo S, Y1 - 2010/02/10/ PY - 2009/12/01/received PY - 2010/01/10/revised PY - 2010/01/29/accepted PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/7/20/medline SP - 1085 EP - 96 JF - Neuropharmacology JO - Neuropharmacology VL - 58 IS - 7 N2 - BACKGROUND: The analysis of licking microstructure provides measures, such as duration and number of licking bouts, which might reveal the former an evaluation process and the latter an approach response. Dopamine D2-like receptor antagonists reduce the duration of licking bouts and mimic the effect of reducing sucrose concentration, while conflicting results are reported on the effects of dopamine D1-like receptor antagonists. The aim of this study is to examine the roles of dopamine D1-like and D2-like receptors in the activation of reward-associated responses and in reward evaluation, through the study of licking microstructure. METHODS: The effects of the dopamine D2-like receptor antagonists raclopride (0.025-0.25 mg/kg), the D1-like antagonist SCH 23390 (0.01-0.04 mg/kg) and the antipsychotic drug haloperidol (0.02-0.05 mg/kg), have been examined on the microstructure of licking for a 10% sucrose solution in rats. RESULTS: The results confirm that dopamine D2-like receptor antagonists reduce the duration of licking bouts and reveal that while SCH 23390 reduced licking exclusively by reducing bout number, raclopride produced on this measure an extinction mimicry effect similar to that observed in instrumental responding for different rewards. DISCUSSION: These results are consistent with the hypothesis that the level of activation of the responses to the reward-associated cues depends on dopamine D1-like receptor stimulation, and is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process occurring during the consummatory transaction with the reward. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/20149807/Dopamine_on_D2_like_receptors_"reboosts"_dopamine_D1_like_receptor_mediated_behavioural_activation_in_rats_licking_for_sucrose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(10)00031-6 DB - PRIME DP - Unbound Medicine ER -