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Antioxidant and antimutagenic activity of Carum copticum fruit extracts.
Toxicol In Vitro. 2010 Jun; 24(4):1243-9.TV

Abstract

The ajowain (Carum copticum (L.)) is a popular spice and traditionally used in Indian system of medicine. Considering the importance of natural products in modern phytomedicine, the antioxidant and antimutagenic activities of C. copticum fruits extract and its fractions were evaluated. The methanol fraction showed highest antioxidant activity by phosphomolybdenum (2087.7 micromol) and DPPH assay (90.2%) followed by other fractions comparable to ascorbic acid and BHT. Based on antioxidant activity, methanol fraction was evaluated for antimutagenic potential against direct acting mutagens sodium azide (NaN(3)) and methyl methane sulphonate (MMS) and indirect acting mutagens 2-aminofluorene (2-AF) and benzo(a)pyrene (B(a)P), using Salmonella typhimurium (TA97a, TA98, TA100, and TA102) tester strains. The methanolic fraction showed no sign of mutagenicity at tested concentrations (25-100 microg/plate). Antimutagenic activity was recorded with inhibition of mutagenicity ranging from 10.8% to 83.1% in a concentration dependent manner. The phytochemical analysis by IR, HPLC, GC-MS, and total phenolic assay revealed a high content of phenolic terpenoids. Further, characterization of active principle is needed to understand the mechanism of action and therapeutic efficacy in vivo.

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Authors+Show Affiliations

Zahin M
Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002, India.
Ahmad I
No affiliation info available
Aqil F
No affiliation info available

MeSH

Antimutagenic AgentsAntioxidantsCarumFruitPlant Extracts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20149861

Citation

Zahin, Maryam, et al. "Antioxidant and Antimutagenic Activity of Carum Copticum Fruit Extracts." Toxicology in Vitro : an International Journal Published in Association With BIBRA, vol. 24, no. 4, 2010, pp. 1243-9.
Zahin M, Ahmad I, Aqil F. Antioxidant and antimutagenic activity of Carum copticum fruit extracts. Toxicol In Vitro. 2010;24(4):1243-9.
Zahin, M., Ahmad, I., & Aqil, F. (2010). Antioxidant and antimutagenic activity of Carum copticum fruit extracts. Toxicology in Vitro : an International Journal Published in Association With BIBRA, 24(4), 1243-9. https://doi.org/10.1016/j.tiv.2010.02.004
Zahin M, Ahmad I, Aqil F. Antioxidant and Antimutagenic Activity of Carum Copticum Fruit Extracts. Toxicol In Vitro. 2010;24(4):1243-9. PubMed PMID: 20149861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and antimutagenic activity of Carum copticum fruit extracts. AU - Zahin,Maryam, AU - Ahmad,Iqbal, AU - Aqil,Farrukh, Y1 - 2010/02/08/ PY - 2009/07/30/received PY - 2009/12/24/revised PY - 2010/02/04/accepted PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/6/18/medline SP - 1243 EP - 9 JF - Toxicology in vitro : an international journal published in association with BIBRA JO - Toxicol In Vitro VL - 24 IS - 4 N2 - The ajowain (Carum copticum (L.)) is a popular spice and traditionally used in Indian system of medicine. Considering the importance of natural products in modern phytomedicine, the antioxidant and antimutagenic activities of C. copticum fruits extract and its fractions were evaluated. The methanol fraction showed highest antioxidant activity by phosphomolybdenum (2087.7 micromol) and DPPH assay (90.2%) followed by other fractions comparable to ascorbic acid and BHT. Based on antioxidant activity, methanol fraction was evaluated for antimutagenic potential against direct acting mutagens sodium azide (NaN(3)) and methyl methane sulphonate (MMS) and indirect acting mutagens 2-aminofluorene (2-AF) and benzo(a)pyrene (B(a)P), using Salmonella typhimurium (TA97a, TA98, TA100, and TA102) tester strains. The methanolic fraction showed no sign of mutagenicity at tested concentrations (25-100 microg/plate). Antimutagenic activity was recorded with inhibition of mutagenicity ranging from 10.8% to 83.1% in a concentration dependent manner. The phytochemical analysis by IR, HPLC, GC-MS, and total phenolic assay revealed a high content of phenolic terpenoids. Further, characterization of active principle is needed to understand the mechanism of action and therapeutic efficacy in vivo. SN - 1879-3177 UR - https://www.unboundmedicine.com/medline/citation/20149861/Antioxidant_and_antimutagenic_activity_of_Carum_copticum_fruit_extracts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-2333(10)00018-4 DB - PRIME DP - Unbound Medicine ER -