Tags

Type your tag names separated by a space and hit enter

Indoor determinants of endotoxin and dust mite exposures in Hong Kong homes with asthmatic children.
Int Arch Allergy Immunol 2010; 152(3):279-87IA

Abstract

BACKGROUND

Domestic endotoxin enhances airway inflammation and increases asthma severity in Caucasian children, but little data are published on indoor endotoxin exposure in Asian countries. This study investigated house dust endotoxin and Der p 1 levels in Hong Kong families with asthmatic children, and their effects on asthma severity.

METHODS

115 asthmatics from a pediatric clinic underwent fractional exhaled nitric oxide (FeNO) and spirometric measurements. Home visits were then made within 2 weeks, during which parents completed the International Study of Asthma and Allergies in Childhood questionnaire. Settled dust was collected from patients' mattresses, bedroom floors and living room floors. Endotoxin and Der p 1 were measured by limulus amebocyte lysate and immunoassay, respectively.

RESULTS

Endotoxin was detectable in all locations from all families, whereas Der p 1 was detectable in 58-70% of indoor sites. Floors of both bedroom and living rooms had higher endotoxin but lower Der p 1 levels than mattresses (p < 0.001 for both). Mattress endotoxin level correlated inversely with Der p 1 level (r = -0.308, p = 0.001). Household smoker, feather bedding and vacuum cleaning were independent determinants of indoor endotoxin. Timing of last bedding change was associated with Der p 1 levels at all sites. Mattress endotoxin level was associated with frequency of wheezing episodes (p = 0.044), but neither endotoxin nor Der p 1 was associated with FeNO and spirometric parameters.

CONCLUSIONS

Domestic endotoxin levels are associated with frequency of wheezing episodes in asthmatic children but not their FeNO or spirometric measurements.

Authors+Show Affiliations

Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20150746

Citation

Leung, Ting Fan, et al. "Indoor Determinants of Endotoxin and Dust Mite Exposures in Hong Kong Homes With Asthmatic Children." International Archives of Allergy and Immunology, vol. 152, no. 3, 2010, pp. 279-87.
Leung TF, Wong YS, Chan IH, et al. Indoor determinants of endotoxin and dust mite exposures in Hong Kong homes with asthmatic children. Int Arch Allergy Immunol. 2010;152(3):279-87.
Leung, T. F., Wong, Y. S., Chan, I. H., Yung, E., Wong, C. K., Lam, C. W., & Wong, G. W. (2010). Indoor determinants of endotoxin and dust mite exposures in Hong Kong homes with asthmatic children. International Archives of Allergy and Immunology, 152(3), pp. 279-87. doi:10.1159/000283039.
Leung TF, et al. Indoor Determinants of Endotoxin and Dust Mite Exposures in Hong Kong Homes With Asthmatic Children. Int Arch Allergy Immunol. 2010;152(3):279-87. PubMed PMID: 20150746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indoor determinants of endotoxin and dust mite exposures in Hong Kong homes with asthmatic children. AU - Leung,Ting Fan, AU - Wong,Yun Sze, AU - Chan,Iris H S, AU - Yung,Edmund, AU - Wong,Chun Kwok, AU - Lam,Christopher W K, AU - Wong,Gary W K, Y1 - 2010/02/12/ PY - 2009/05/04/received PY - 2009/09/22/accepted PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/8/10/medline SP - 279 EP - 87 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 152 IS - 3 N2 - BACKGROUND: Domestic endotoxin enhances airway inflammation and increases asthma severity in Caucasian children, but little data are published on indoor endotoxin exposure in Asian countries. This study investigated house dust endotoxin and Der p 1 levels in Hong Kong families with asthmatic children, and their effects on asthma severity. METHODS: 115 asthmatics from a pediatric clinic underwent fractional exhaled nitric oxide (FeNO) and spirometric measurements. Home visits were then made within 2 weeks, during which parents completed the International Study of Asthma and Allergies in Childhood questionnaire. Settled dust was collected from patients' mattresses, bedroom floors and living room floors. Endotoxin and Der p 1 were measured by limulus amebocyte lysate and immunoassay, respectively. RESULTS: Endotoxin was detectable in all locations from all families, whereas Der p 1 was detectable in 58-70% of indoor sites. Floors of both bedroom and living rooms had higher endotoxin but lower Der p 1 levels than mattresses (p < 0.001 for both). Mattress endotoxin level correlated inversely with Der p 1 level (r = -0.308, p = 0.001). Household smoker, feather bedding and vacuum cleaning were independent determinants of indoor endotoxin. Timing of last bedding change was associated with Der p 1 levels at all sites. Mattress endotoxin level was associated with frequency of wheezing episodes (p = 0.044), but neither endotoxin nor Der p 1 was associated with FeNO and spirometric parameters. CONCLUSIONS: Domestic endotoxin levels are associated with frequency of wheezing episodes in asthmatic children but not their FeNO or spirometric measurements. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/20150746/Indoor_determinants_of_endotoxin_and_dust_mite_exposures_in_Hong_Kong_homes_with_asthmatic_children_ L2 - https://www.karger.com?DOI=10.1159/000283039 DB - PRIME DP - Unbound Medicine ER -