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Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury.
Pharmacology. 2010; 85(3):158-67.P

Abstract

We investigated the protective effect of telmisartan, an angiotensin II receptor antagonist, against ischemia/reperfusion renal injury in rats. Bilateral ischemia was induced by clamping both renal vascular pedicles for 45 min followed by reperfusion for 3 h. Untreated rats exposed to ischemia/reperfusion showed significant elevations in blood urea nitrogen and serum creatinine levels, renal tissue levels of malondialdehyde, tumor necrosis factor-alpha and nitric oxide, and caspase-3 activity. This was associated with significant decreases in renal reduced glutathione level, catalase and superoxide dismutase activities. Also, significant increases in serum and renal tissue levels of homocysteine were detected following ischemia/reperfusion. Pre-ischemic treatment with telmisartan (0.3 mg/kg/day, i.p.) for 7 consecutive days significantly attenuated the increases in blood urea nitrogen, serum creatinine, renal malondialdehyde, tumor necrosis factor-alpha, nitric oxide, caspase-3 activity, and serum and renal homocysteine levels, and significantly restored the renal antioxidant defenses. In addition, light and electron microscopic examinations revealed that telmisartan pre-treatment markedly ameliorated ischemia/reperfusion-induced renal tissue damage. It was concluded that telmisartan, through its antioxidant, anti-inflammatory and antiapoptotic effects, can be considered a potential candidate to protect against acute ischemia/reperfusion renal injury.

Authors+Show Affiliations

Department of Biomedical Sciences, Pharmacology Division, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia. amrfouad65@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20150754

Citation

Fouad, Amr A., et al. "Nephroprotective Effect of Telmisartan in Rats With Ischemia/reperfusion Renal Injury." Pharmacology, vol. 85, no. 3, 2010, pp. 158-67.
Fouad AA, Qureshi HA, Al-Sultan AI, et al. Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury. Pharmacology. 2010;85(3):158-67.
Fouad, A. A., Qureshi, H. A., Al-Sultan, A. I., Yacoubi, M. T., & Al-Melhim, W. N. (2010). Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury. Pharmacology, 85(3), 158-67. https://doi.org/10.1159/000269779
Fouad AA, et al. Nephroprotective Effect of Telmisartan in Rats With Ischemia/reperfusion Renal Injury. Pharmacology. 2010;85(3):158-67. PubMed PMID: 20150754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephroprotective effect of telmisartan in rats with ischemia/reperfusion renal injury. AU - Fouad,Amr A, AU - Qureshi,Habib A, AU - Al-Sultan,Ali Ibrahim, AU - Yacoubi,Mohamed T, AU - Al-Melhim,Walid N, Y1 - 2010/02/11/ PY - 2009/10/09/received PY - 2009/12/08/accepted PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/5/29/medline SP - 158 EP - 67 JF - Pharmacology JO - Pharmacology VL - 85 IS - 3 N2 - We investigated the protective effect of telmisartan, an angiotensin II receptor antagonist, against ischemia/reperfusion renal injury in rats. Bilateral ischemia was induced by clamping both renal vascular pedicles for 45 min followed by reperfusion for 3 h. Untreated rats exposed to ischemia/reperfusion showed significant elevations in blood urea nitrogen and serum creatinine levels, renal tissue levels of malondialdehyde, tumor necrosis factor-alpha and nitric oxide, and caspase-3 activity. This was associated with significant decreases in renal reduced glutathione level, catalase and superoxide dismutase activities. Also, significant increases in serum and renal tissue levels of homocysteine were detected following ischemia/reperfusion. Pre-ischemic treatment with telmisartan (0.3 mg/kg/day, i.p.) for 7 consecutive days significantly attenuated the increases in blood urea nitrogen, serum creatinine, renal malondialdehyde, tumor necrosis factor-alpha, nitric oxide, caspase-3 activity, and serum and renal homocysteine levels, and significantly restored the renal antioxidant defenses. In addition, light and electron microscopic examinations revealed that telmisartan pre-treatment markedly ameliorated ischemia/reperfusion-induced renal tissue damage. It was concluded that telmisartan, through its antioxidant, anti-inflammatory and antiapoptotic effects, can be considered a potential candidate to protect against acute ischemia/reperfusion renal injury. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/20150754/Nephroprotective_effect_of_telmisartan_in_rats_with_ischemia/reperfusion_renal_injury_ L2 - https://www.karger.com?DOI=10.1159/000269779 DB - PRIME DP - Unbound Medicine ER -