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Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom.
Chem Biodivers. 2010 Feb; 7(2):392-9.CB

Abstract

A new sesquiterpene ester, tunetanin A (1), a new sesquiterpene coumarin, tunetacoumarin A (2), together with eight known compounds, i.e., coladin (3), coladonin (4), isosmarcandin (5), 13-hydroxyfeselol (6), umbelliprenin (7) propiophenone (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D- and 2D-NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1-7 towards two human colon cancer cell lines, HT-29 and HCT 116, was evaluated. Compounds 3, 4, and 6 showed weak cytotoxic activities.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Jabrane A
Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, 5000 Monastir, Tunisie.
Ben Jannet H
No affiliation info available
Mighri Z
No affiliation info available
Mirjolet JF
No affiliation info available
Duchamp O
No affiliation info available
Harzallah-Skhiri F
No affiliation info available
Lacaille-Dubois MA
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationCoumarinsDrug Screening Assays, AntitumorFerulaHumansMagnetic Resonance SpectroscopyPlant RootsSesquiterpenesSpecies SpecificityStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20151385

Citation

Jabrane, Aymen, et al. "Two New Sesquiterpene Derivatives From the Tunisian Endemic Ferula Tunetana Pom." Chemistry & Biodiversity, vol. 7, no. 2, 2010, pp. 392-9.
Jabrane A, Ben Jannet H, Mighri Z, et al. Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom. Chem Biodivers. 2010;7(2):392-9.
Jabrane, A., Ben Jannet, H., Mighri, Z., Mirjolet, J. F., Duchamp, O., Harzallah-Skhiri, F., & Lacaille-Dubois, M. A. (2010). Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom. Chemistry & Biodiversity, 7(2), 392-9. https://doi.org/10.1002/cbdv.200900025
Jabrane A, et al. Two New Sesquiterpene Derivatives From the Tunisian Endemic Ferula Tunetana Pom. Chem Biodivers. 2010;7(2):392-9. PubMed PMID: 20151385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom. AU - Jabrane,Aymen, AU - Ben Jannet,Hichem, AU - Mighri,Zine, AU - Mirjolet,Jean-François, AU - Duchamp,Olivier, AU - Harzallah-Skhiri,Féthia, AU - Lacaille-Dubois,Marie-Aleth, PY - 2010/2/13/entrez PY - 2010/2/13/pubmed PY - 2010/5/19/medline SP - 392 EP - 9 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 7 IS - 2 N2 - A new sesquiterpene ester, tunetanin A (1), a new sesquiterpene coumarin, tunetacoumarin A (2), together with eight known compounds, i.e., coladin (3), coladonin (4), isosmarcandin (5), 13-hydroxyfeselol (6), umbelliprenin (7) propiophenone (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D- and 2D-NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1-7 towards two human colon cancer cell lines, HT-29 and HCT 116, was evaluated. Compounds 3, 4, and 6 showed weak cytotoxic activities. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/20151385/Two_new_sesquiterpene_derivatives_from_the_Tunisian_endemic_Ferula_tunetana_Pom_ L2 - https://doi.org/10.1002/cbdv.200900025 DB - PRIME DP - Unbound Medicine ER -