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Electroanalytical determination of estriol hormone using a boron-doped diamond electrode.
Talanta. 2010 Mar 15; 80(5):1999-2006.T

Abstract

A boron-doped diamond (BDD) electrode was used for the electroanalytical determination of estriol hormone in a pharmaceutical product and a urine sample taken during pregnancy by square-wave voltammetry. The optimized experimental conditions were: (1) a supporting electrolyte solution of NaOH at a pH of 12.0, and (2) a frequency of 20 Hz, a pulse height of 30 mV and a scan increment of 2 mV (for the square-wave parameters). The analytical curve was linear in the concentration range of 2.0 x 10(-7) to 2.0 x 10(-5) mol L(-1) (r=0.9994), with a detection limit of 1.7 x 10(-7) mol L(-1) and quantification limit of 8.5 x 10(-7) mol L(-1). Recoveries of estriol were in the range of 98.6-101.0%, for the pharmaceutical sample, and 100.2-103.4% for the urine sample, indicating no significant matrix interference effects on the analytical results. The accuracy of the electroanalytical methodology proposed was compared to that of the radioimmunoassay method. The values for the relative error between the proposed and standard methods were -7.29% for the determination of estriol in the commercial product and -4.98% in a urine sample taken during pregnancy. The results obtained suggest a reliable and interesting alternative method for electroanalytical determination of estriol in pharmaceutical products and urine samples taken during pregnancy using a boron-doped diamond electrode.

Authors+Show Affiliations

Departamento de Química - CFM, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

20152445

Citation

Santos, Keliana D., et al. "Electroanalytical Determination of Estriol Hormone Using a Boron-doped Diamond Electrode." Talanta, vol. 80, no. 5, 2010, pp. 1999-2006.
Santos KD, Braga OC, Vieira IC, et al. Electroanalytical determination of estriol hormone using a boron-doped diamond electrode. Talanta. 2010;80(5):1999-2006.
Santos, K. D., Braga, O. C., Vieira, I. C., & Spinelli, A. (2010). Electroanalytical determination of estriol hormone using a boron-doped diamond electrode. Talanta, 80(5), 1999-2006. https://doi.org/10.1016/j.talanta.2009.10.058
Santos KD, et al. Electroanalytical Determination of Estriol Hormone Using a Boron-doped Diamond Electrode. Talanta. 2010 Mar 15;80(5):1999-2006. PubMed PMID: 20152445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroanalytical determination of estriol hormone using a boron-doped diamond electrode. AU - Santos,Keliana D, AU - Braga,Otoniel C, AU - Vieira,Iolanda C, AU - Spinelli,Almir, Y1 - 2009/11/01/ PY - 2009/06/12/received PY - 2009/10/24/revised PY - 2009/10/27/accepted PY - 2010/2/16/entrez PY - 2010/2/16/pubmed PY - 2010/5/19/medline SP - 1999 EP - 2006 JF - Talanta JO - Talanta VL - 80 IS - 5 N2 - A boron-doped diamond (BDD) electrode was used for the electroanalytical determination of estriol hormone in a pharmaceutical product and a urine sample taken during pregnancy by square-wave voltammetry. The optimized experimental conditions were: (1) a supporting electrolyte solution of NaOH at a pH of 12.0, and (2) a frequency of 20 Hz, a pulse height of 30 mV and a scan increment of 2 mV (for the square-wave parameters). The analytical curve was linear in the concentration range of 2.0 x 10(-7) to 2.0 x 10(-5) mol L(-1) (r=0.9994), with a detection limit of 1.7 x 10(-7) mol L(-1) and quantification limit of 8.5 x 10(-7) mol L(-1). Recoveries of estriol were in the range of 98.6-101.0%, for the pharmaceutical sample, and 100.2-103.4% for the urine sample, indicating no significant matrix interference effects on the analytical results. The accuracy of the electroanalytical methodology proposed was compared to that of the radioimmunoassay method. The values for the relative error between the proposed and standard methods were -7.29% for the determination of estriol in the commercial product and -4.98% in a urine sample taken during pregnancy. The results obtained suggest a reliable and interesting alternative method for electroanalytical determination of estriol in pharmaceutical products and urine samples taken during pregnancy using a boron-doped diamond electrode. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/20152445/Electroanalytical_determination_of_estriol_hormone_using_a_boron_doped_diamond_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(09)00847-9 DB - PRIME DP - Unbound Medicine ER -