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Effects of reversible inactivation of the medial septum on rat exploratory behavior in the elevated plus-maze using a test-retest paradigm.
Behav Brain Res. 2010 Jun 26; 210(1):67-73.BB

Abstract

The effect of intraseptal injections of lidocaine before a first or a second session in the elevated plus-maze, in a test-retest paradigm, was investigated. In addition to gross session analyses, a minute-by-minute analysis of the sessions was used to evaluate both anxiety and memory. Lidocaine injections before the test session produced increases in the frequency of entries, time spent and distance run in the open arms without affecting activity occurring in the closed arms. During the retest session, saline- and lidocaine-treated rats exhibited increased indices of anxiety and lidocaine-treated rats exhibited decreased closed-arm entries. The minute-by-minute analysis showed a faster decrease in anxiety-related behaviors during the test session by saline- than by lidocaine-treated rats and a significant decrease in closed-arm exploration by saline-treated rats, but not by lidocaine-treated ones. Lidocaine injection before the retest session produced increases in the frequency of entries, time spent and distance run in the open arms in the second session when compared with saline-treated rats. Minute-by-minute analysis showed an increase in the time spent in the open arms by lidocaine animals at the beginning of the retest session in comparison to saline animals and a significant decrease in closed-arm exploration by both groups. These results suggest that inactivation of the medial septum by lidocaine affects the expression of unconditioned and conditioned forms of anxiety in the elevated plus-maze and, in a lesser way, the acquisition and retention of spatial information.

Authors+Show Affiliations

Departamento de Psicología, Facultad de Ciencias Humanas, Universidad Nacional de Colombia, Sede Bogotá, Colombia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20153380

Citation

Lamprea, Marisol Rodríguez, et al. "Effects of Reversible Inactivation of the Medial Septum On Rat Exploratory Behavior in the Elevated Plus-maze Using a Test-retest Paradigm." Behavioural Brain Research, vol. 210, no. 1, 2010, pp. 67-73.
Lamprea MR, Garcia AM, Morato S. Effects of reversible inactivation of the medial septum on rat exploratory behavior in the elevated plus-maze using a test-retest paradigm. Behav Brain Res. 2010;210(1):67-73.
Lamprea, M. R., Garcia, A. M., & Morato, S. (2010). Effects of reversible inactivation of the medial septum on rat exploratory behavior in the elevated plus-maze using a test-retest paradigm. Behavioural Brain Research, 210(1), 67-73. https://doi.org/10.1016/j.bbr.2010.02.011
Lamprea MR, Garcia AM, Morato S. Effects of Reversible Inactivation of the Medial Septum On Rat Exploratory Behavior in the Elevated Plus-maze Using a Test-retest Paradigm. Behav Brain Res. 2010 Jun 26;210(1):67-73. PubMed PMID: 20153380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of reversible inactivation of the medial septum on rat exploratory behavior in the elevated plus-maze using a test-retest paradigm. AU - Lamprea,Marisol Rodríguez, AU - Garcia,Andrea Milena Becerra, AU - Morato,Silvio, Y1 - 2010/02/11/ PY - 2009/09/18/received PY - 2010/02/02/revised PY - 2010/02/05/accepted PY - 2010/2/16/entrez PY - 2010/2/16/pubmed PY - 2010/7/1/medline SP - 67 EP - 73 JF - Behavioural brain research JO - Behav Brain Res VL - 210 IS - 1 N2 - The effect of intraseptal injections of lidocaine before a first or a second session in the elevated plus-maze, in a test-retest paradigm, was investigated. In addition to gross session analyses, a minute-by-minute analysis of the sessions was used to evaluate both anxiety and memory. Lidocaine injections before the test session produced increases in the frequency of entries, time spent and distance run in the open arms without affecting activity occurring in the closed arms. During the retest session, saline- and lidocaine-treated rats exhibited increased indices of anxiety and lidocaine-treated rats exhibited decreased closed-arm entries. The minute-by-minute analysis showed a faster decrease in anxiety-related behaviors during the test session by saline- than by lidocaine-treated rats and a significant decrease in closed-arm exploration by saline-treated rats, but not by lidocaine-treated ones. Lidocaine injection before the retest session produced increases in the frequency of entries, time spent and distance run in the open arms in the second session when compared with saline-treated rats. Minute-by-minute analysis showed an increase in the time spent in the open arms by lidocaine animals at the beginning of the retest session in comparison to saline animals and a significant decrease in closed-arm exploration by both groups. These results suggest that inactivation of the medial septum by lidocaine affects the expression of unconditioned and conditioned forms of anxiety in the elevated plus-maze and, in a lesser way, the acquisition and retention of spatial information. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20153380/Effects_of_reversible_inactivation_of_the_medial_septum_on_rat_exploratory_behavior_in_the_elevated_plus_maze_using_a_test_retest_paradigm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00111-7 DB - PRIME DP - Unbound Medicine ER -